Leigh Anne Dageforde

Increased minimum vein diameter on preoperative mapping with duplex ultrasound is associated with arteriovenous fistula maturation and secondary patency

OBJECTIVE Autogenous arteriovenous hemodialysis accesses (arteriovenous fistulas [AVFs]) are preferred for chronic hemodialysis access. Preoperative vein mapping by duplex ultrasound is recommended before AVF creation, but there are few data correlating vein diameter with postoperative outcomes. Also, vein diameter has not been included in prior predictive models of fistula maturation. This study aims to test whether preoperative vein diameter is associated with failure of AVF maturation and long-term (secondary) patency. METHODS We performed a retrospective analysis of clinical variables of patients undergoing brachiobasilic or brachiocephalic AVF creation. Kaplan-Meier and multivariate Cox regression models tested whether preoperative minimum vein diameter (MVD) and clinical covariates were associated with failure of AVF maturation and secondary patency. RESULTS The sample included 158 adults (54 ± 14 years; 45% male; 61% white; 56% diabetes; body mass index, 32 ± 8; MVD, 3.4 ± 1.1 mm; follow-up, 12 ± 9 months [range, <1-40 months]). Increased MVD was associated with decreased risk of AVF failure. More than one third of AVFs with MVD <2.7 mm failed to mature within 6 months. Multivariate models that adjusted for age, diabetes, race, gender, body mass index, and preoperative dialysis status demonstrated that increased MVD was associated with decreased risk of failure of maturation and better long-term patency overall (P = .005 and P = .001, respectively). CONCLUSIONS Patients with a larger MVD on preoperative vein mapping are at lower risk for failure of fistula maturation and have increased long-term AVF patency. MVD is the only clinical or demographic factor associated with both AVF maturation and long-term patency. MVD is an important preoperative indicator of fistula success in assessment of potential AVF sites. Future predictive models of fistula maturation and patency should include MVD.

Health Literacy of Living Kidney Donors and Kidney Transplant Recipients

Background Health literacy (HL) may be a mediator for known socioeconomic and racial disparities in living kidney donation. Methods We evaluated the associations of patient and demographic characteristics with HL in living kidney donors (LD), living donor kidney transplant recipients (LDR), and deceased donor recipients (DDR) in a single-center retrospective review of patients undergoing kidney donation or transplantation from September 2010 to July 2012. HL and demographic data were collected. HL was assessed via the Short Literacy Survey (SLS) comprising three self-reported screening questions scored using the five-point Likert scale (low [3–8], moderate [9–14], high [15]). Chi-square and logistic regression were used to test factors associated with lower HL. Results The sample included 360 adults (105 LD, 103 LDR, and 152 DDR; 46±14 years; 70% white; 56% male; 14±3 years of education). HL scores were skewed (49% high, 41% moderate, and 10% low). The distribution of HL categories differed significantly among groups (P=0.019). After controlling for age, race, sex, education, and a race-education interaction term, DDR was more likely to have moderate or low HL than LDR (OR, 1.911; 95%CI, 1.096–3.332; P=0.022). Conclusion Overall, living donors had high HL. The distribution of low, moderate, and high HL differed significantly between LD, DDR, and LDR. DDR had a higher likelihood of having low HL than LDR. Screening kidney transplant candidates and donors for lower HL may identify barriers to living donation. Future interventions addressing HL may be important to increase living donation and reduce disparities.

Recruiting women to vascular surgery and other surgical specialties

Vascular surgery is a subspecialty that attracts future surgeons with challenging technical procedures and complex decision making. Despite its appeal, continued promotion of the field is necessary to recruit and retain the best and brightest candidates. Recruitment of medical students and residents may be limited by the lifestyle inherent to vascular surgery and the length of residency training. The young adults of the current applicant and resident pool differ from prior generations in their desire for hands-on mentoring, aspirations to affect change daily, a penchant for technology, and strong emphasis on work-life balance. Furthermore, the percentage of women pursuing careers in vascular surgery is not representative of the eligible workforce. Women are now the majority of graduates in all of higher education, and thus, vascular surgery may need to make a concerted effort to appeal to women in order to attract the most talented young professionals to the field. Recruiting strategies for both men and women of Generation Y should target a diverse group of potential candidates with an awareness of the unique characteristics and needs of this generation of rising surgeons.

A Cost-Effectiveness Analysis of Early vs Late Reconstruction of Iatrogenic Bile Duct Injuries

BACKGROUND Controversy exists regarding the optimal timing of repair after iatrogenic bile duct injuries (BDI). Several studies advocate late repair (≥6 weeks after injury) with mandatory drainage and resolution of inflammation. Others indicate that early repair (<6 weeks after injury) produces comparable or superior clinical outcomes. Additionally, although most studies have reported inferior outcomes with primary surgeon repair, this practice continues. With disparate published recommendations and rising health care costs, decision analysis was used to examine the cost-effectiveness of BDI repair. STUDY DESIGN A Markov model was developed to evaluate primary surgeon repair (PSR), late repair by a hepatobiliary surgeon (LHBS), and early repair by a hepatobiliary surgeon (EHBS). Baseline values and ranges were collected from the literature. Sensitivity analsyses were conducted to test the strength of the model and variability of parameters. RESULTS The model demonstrated that EHBS was associated with lower costs, earlier return to normal activity, and better quality of life. Specifically, 1 year after repair, PSR yielded 0.53 quality adjusted life years (QALYs) (

Hemodialysis Reliable Outflow (HeRO) device in end-stage dialysis access: a decision analysis model

120,000/QALY) and LHBS yielded 0.74 QALYs (

Understanding Patient Barriers to Kidney Transplant Evaluation.

74,000/QALY); EHBS yielded 0.82 QALYs (

Laparoscopic versus open peritoneal dialysis catheter insertion cost analysis

48,000/QALY). Sensitivity analyses supported these findings at clinically meaningful probabilities. CONCLUSIONS This cost-effectiveness model demonstrates that early repair by a hepatobiliary surgeon is the superior strategy for the treatment of BDI in properly selected patients. Although there is little clinical difference between early and late repair, there is a great difference in cost and quality of life. Ideally, costs and quality of life should be considered in decisions regarding strategies of repair of injured bile ducts.

Comparison of open live donor nephrectomy, laparoscopic live donor nephrectomy, and hand-assisted live donor nephrectomy: A cost-minimization analysis

BACKGROUND The Hemodialysis Reliable Outflow (HeRO) dialysis access device is a permanent tunneled dialysis graft connected to a central venous catheter and is used in patients with end-stage dialysis access (ESDA) issues secondary to central venous stenosis. The safety and effectiveness of the HeRO device has previously been proven, but no study thus far has compared the cost of its use with tunneled dialysis catheters (TDCs) and thigh grafts in patients with ESDA. MATERIALS AND METHODS A decision analytic model was developed to simulate outcomes for patients with ESDA undergoing placement of a HeRO dialysis access device, TDC, or thigh graft. Outcomes of interest were infection, thrombosis, and ischemic events. Baseline values, ranges, and costs were determined from a systematic review of the literature. Total costs were based on 1 year of post-procedure outcomes. Sensitivity analyses were conducted to test model strength. RESULTS The HeRO dialysis access device is the least costly dialysis access with an average 1-year cost of

Validation of the Written Administration of the Short Literacy Survey

6521. The 1-year cost for a TDC was

Is liver transplantation using organs donated after cardiac death cost‐effective or does it decrease waitlist death by increasing recipient death?

8477. A thigh graft accounted for