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Featured researches published by Leila Servat.


European Journal of Pharmacology | 2011

Geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester isolated from Pterodon pubescens Benth.: Further investigation on the antinociceptive mechanisms of action.

Humberto M. Spindola; Leila Servat; Rodney Alexandre Ferreira Rodrigues; Ilza Maria de Oliveira Sousa; João Ernesto de Carvalho; Mary Ann Foglio

The crude alcoholic extracts obtained from Pterodon pubescens Benth. seeds are widely used in Brazilian folk medicine as anti-inflammatory, analgesic, anti-rheumatic tonics and depurative preparations. We previously demonstrated the antinociceptive activity on writhing capsaicin, glutamate, and hot-plate tests of two compounds isolated from P. pubescens: geranylgeraniol (C1) and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester (C2). This work is a continuation of the previous study investigating the possible mechanisms of action for compounds C1 and C2, and the differences between them. The present study demonstrated that when administered intraperitoneally (i.p.): i), compounds C1 and C2 produced significant anti-allodynic activity during the acute phase of the Complete Freunds Adjuvant (CFA)-induced persistent pain model; ii) compound C1 produced significant anti-hypernociception activity in the carrageenan-induced pain model; iii) compound C2 presented a significant loss of activity after p-chlorophenylalanine methyl ester hydrochloride (PCPA) [5-HT synthesis inhibitor] treatment, suggesting that the mechanisms of action could be related to either the synthesis or release of serotonin; iv) compound C1 presented a significant loss of activity after ondansetron (5-HT(3) receptor antagonist) treatment suggesting activity upon 5-HT(3) serotonin receptors; v) compound C1 presented a significant loss of activity after efaroxan (mixed I(1) imidazoline/α(2)-adrenoceptor antagonist) treatment suggesting the participation of this compound upon imidazoline I(1) receptors; and vi) both compounds C1 and C2 did not appear to exert their activity via 5-HT(1A), 5-HT(2A), imidazoline I(2), α(2)-adrenoceptor, nitric oxide, GABA(A), acetylcholine muscarinic, and nicotinic receptors when evaluated in acetic acid-induced nociception.


Journal of the Brazilian Chemical Society | 2012

Pterodon pubescens benth: stability study of microencapsulated extract and isolated compounds monitored by antinociceptive assays

Leila Servat; Humberto M. Spindola; Rodney Alexandre Ferreira Rodrigues; Ilza Maria de Oliveira Sousa; João Ernesto de Carvalho; Mary Ann Foglio

Pterodon pubescens Benth. (Pp) seeds, commercially available in Brazil, are used in folk medicine in anti-inflammatory, analgesic, and anti-rheumatic preparations. The present study demonstrated the antinociceptive properties of isomers 6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester (C1), isolated from (Pp), employing different experimental models. A stability study was performed to investigate the relationship of microencapsulation by spray-drying on the maintenance of antinociceptive action. Therefore, C1 and Pp extract samples were monitored in accelerated stability study, evaluating both microencapsulated and non-microencapsulated samples. It was observed that sample C1 possess antinociceptive activity revealed by writhing and formalin tests; C1 showed significantly anti-allodynic, but not antihyperalgesic effect; the microencapsulation maintained the activity and integrity of both, sample C1 and Pp crude extract; microencapsulation by spray drying is a useful alternative to increase shelf life.


BMC Pharmacology | 2010

Antinociceptive effect of geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester isolated from Pterodon pubescens Benth

Humberto M. Spindola; Leila Servat; Carina Denny; Rodney Af Rodrigues; Marcos N. Eberlin; Elaine C. Cabral; Ilza Mo Sousa; Jorge Yoshio Tamashiro; João Ernesto de Carvalho; Mary Ann Foglio


Archive | 2012

Pharmaceutical compositions comprising arrabidaea chica extract in controlled release systems, production process and use thereof

Mary Ann Foglio; João Ernesto de Carvalho; Michelle Pedroza Jorge; Leila Servat; Patricia Maria Wiziack Zago; Marcos N. Eberlin; Elaine Cristina Cabral Polcelli; Maria Helena Andrade Santana; Viviane Ferre de Souza; Glyn Mara Figueira; Ilza Maria Oliveira; Rodney Alexandre Ferreira Rodrigues


Archive | 2014

Method for obtaining chitosan-based products enriched with arrabidaea chica

Mary Ann Foglio; Leila Servat; Felisa Reyes Ortega; Álvaro González Gómez; Julio San Román; Ilza Maria Oliveira Souza; Michelle Pedroza Jorge; João Ernesto de Carvalho


Revista Fitos Eletronica | 2013

Microencapsulação: uma Alternativa Promissora para Preservação de Produtos Naturais

Mary Ann Foglio; Leila Servat; Humberto M. Spindola; Rodney Alexandre Ferreira Rodrigues


Planta Medica | 2013

Evaluation of Carajurin Content Arrabidaea Chica Using Different Solvents for Extraction

Imo Sousa; Raf Rodrigues; Nca Queiroz; Michelle Pedroza Jorge; Leila Servat; Mn Eberlin; Mary Ann Foglio


Archive | 2013

PROCESSO DE OBTENÇÃO DE PRODUTOS A BASE DE QUITOSANA E ENRIQUECIDOS COM ARRABIDAEA CHICA

Mary Ann Foglio; Leila Servat; Felisa Reyes Ortega; Álvaro González Gómez; Julio San Román; Ilza Maria Oliveira Souza; Michelle Pedroza Jorge; João Ernesto de Carvalho


Archive | 2013

Procédé d'obtention de produits à base de chitosane et enrichis avec arrabidaea chica

Mary Ann Foglio; Leila Servat; Felisa Reyes Ortega; Álvaro González Gómez; Julio San Román; Ilza Maria Oliveira Souza; Michelle Pedroza Jorge; João Ernesto de Carvalho


Planta Medica | 2012

Pterodon pubescens Benth: Stability study of microencapsulated extract and isolated compounds monitored by antinociceptive assays

Leila Servat; Humberto M. Spindola; Raf Rodrigues; Imo Sousa; Altg Ruiz; Je de Carvalho; Mary Ann Foglio

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Mary Ann Foglio

State University of Campinas

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Humberto M. Spindola

State University of Campinas

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Imo Sousa

State University of Campinas

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Marcos N. Eberlin

State University of Campinas

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Julio San Román

Spanish National Research Council

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Altg Ruiz

State University of Campinas

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