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Len F. Lee

G. D. Searle & Company

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Publication

Featured researches published by Len F. Lee.

Bioorganic & Medicinal Chemistry Letters | 1997

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Thomas D. Penning; Steven W. Kramer; Len F. Lee; Paul W. Collins; Carol M. Koboldt; Karen Seibert; Amy W. Veenhuizen; Yan Y. Zhang; Peter C. Isakson

Abstract A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.

Journal of Medicinal Chemistry | 1997

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning; John J. Talley; Stephen R. Bertenshaw; Jeffery S. Carter; Paul W. Collins; Stephen H Docter; Matthew J. Graneto; Len F. Lee; James W. Malecha; Julie M. Miyashiro; Roland S. Rogers; Donald J. Rogier; Stella S. Yu; Gary D. Anderson; Earl G. Burton; J. Nita Cogburn; Susan A. Gregory; Carol M. Koboldt; William Perkins; Karen Seibert; Amy W. Veenhuizen; and Yan Y. Zhang; Peter C. Isakson

Archive | 1994

Amidino derivatives useful as nitric oxide synthase inhibitors

Donald W. Hansen; Mark G. Currie; E. Ann Hallinan; Kam F. Fok; Timothy J. Hagen; Arija A. Bergmanis; Steven W. Kramer; Len F. Lee; Suzanne Metz; William M. Moore; Karen B. Peterson; Barnett S. Pitzele; Dale P. Spangler; R. Keith Webber; Mihaly V. Toth; Mahima Trivedi; Foe S. Tjoeng

Archive | 1995

3,4-substituted pyrazoles for the treatment of inflammation

Len F. Lee; Thomas D. Penning; Steven W. Kramer

Archive | 1994

Substituted oxazolyl compounds for the treatment of inflammation

Bryan H. Norman; Len F. Lee; Jaime L. Masferrer; John J. Talley

Archive | 1997

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Len F. Lee; Shyamal C. Banerjee; Horng-Chih Huang; Jinglin J. Li; Raymond E. Miller; David B. Reitz; Samuel J. Tremont

Archive | 1996

2,3-substituted pyridines for the treatment of inflammation

Richard M. Weier; Len F. Lee; Richard A. Partis; Francis J. Koszyk

Archive | 2001

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Len F. Lee; Shyamal C. Banerjee; Horng-Chih Huang; Jinglin J. Li; Raymond E. Miller; David B. Reitz; Samuel J. Tremont

Journal of Organic Chemistry | 1976

Cyclization of unsaturated hydroxylamine derivatives

Herbert O. House; David T. Manning; David G. Melillo; Len F. Lee; O. R. Haynes; Bruce E. Wilkes

Archive | 1994

1,5-diphenyl pyrazole compounds for treatment of inflammation

Len F. Lee; Stephen R. Bertenshaw

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William M. Moore

Monsanto

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Foe Siong Tjoeng

Monsanto

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Kam F. Fok

Monsanto

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Suzanne Metz

Monsanto

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Timothy J. Hagen

Pharmacia

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Herbert O. House

Georgia Institute of Technology

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Timothy J. Hagen

Pharmacia

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Ronald Keith Webber

Pharmacia

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Peter C. Isakson

University of Virginia

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Carol M. Koboldt

Monsanto

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