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Dive into the research topics where Lennart Domellöf is active.

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Featured researches published by Lennart Domellöf.


American Journal of Surgery | 1977

The risk for gastric carcinoma after partial gastrectomy.

Lennart Domellöf; Janunger Kg

To study whether gastric resection implies a greater risk for gastric carcinoma than what is expected in a nonoperated population, 676 patients who underwent Billroth I and II resection from ten to twenty years ago were reexamined by gastroscopy. Fourteen patients with carcinomas were found. Statistical evidence shows that male patients resected for benign ulcer disease more than eleven years previously constitute a risk group.


American Journal of Surgery | 1980

Microflora and deconjugation of bile acids in alkaline reflux after partial gastrectomy

Lennart Domellöf; Bandaru S. Reddy; John H. Weisburger

It has been postulated that reflux of bile into the stomach promotes gastric carcinogenesis. Bile-stained aspirates from 50 asymptomatic patients, partially gastrectomized more than 10 years earlier, were examined bacteriologically and with regard to conjugated and deconjugated bile acids. Endoscopic biopsies showed atrophic gastritis in all patients, cancer in two and severe dysplasia in another two. pH in the reflux aspirates was 7.3 +/- 0.4 (mean +/- standard deviation). Bacterial cultures were positive in all patients studied. Fecal type flora, mostly E. coli, klebsiella and Clostridium perfringens, was found in 85% of the patients. Total bile acids were found to be 2.6 +/- 2.0 mg/ml, 23% of which were deconjugated. Deoxycholic acid, known to promote carcinogenesis in animals, amounted to 27% of total bile acids and deconjugated deoxycholic acid was 5% of total bile acids. The mostly anaerobic microflora and the presence of mainly free secondary and primary bile acids may contribute to the high incidence of cancer in the gastric remnant observed after Billroth I or II operations.


American Journal of Surgery | 1976

Late precancerous changes and carcinoma of the gastric stump after Billroth I resection

Lennart Domellöf; Sune Eriksson; Janunger Kg

Carcinoma of the gastric remnant after resection for benign ulcers is regarded as a rare complication after Billroth I resection. In seventy-four patients reexamined by gastroscopy and multiple biopsies ten to twenty-two years after gastric resection four cases of cancer of the gastric stump were diagnosed and the patients operated on. Another eight patients had regenerative polyps and one patient had a tubular adenoma. The histologic findings in gastroscopic biopsy specimens from the gastric stoma and fundus are compared. Possible precancerous changes and etiologic aspects are discussed briefly. Repeated gastroscopy is recommended starting about ten years after gastric resection for benign ulcers.


FEBS Letters | 1980

The bile salt-stimulated lipase in human milk is an evolutionary newcomer derived from a non-milk protein

Lars Bläckberg; Olle Hernell; Thomas Olivecrona; Lennart Domellöf; M.René Malinov

Milk from humans [ 1,2] and gorillas [3] contains an inactive form of a lipase which becomes activated when the milk is mixed with intestinal contents. The activation of the enzyme is caused by interaction with certain bile salts [4]. This lipase contributes substantially to the utilization of milk lipids by the newborn [5]. For instance, heat treatment of human milk inactivates the lipase [4] and reduces fat absorption by -1/3rd in pre-term infants [6]. This bile saltstimulated lipase is not present in milk from rats, guinea pigs, rabbits, dogs, goats, cows, pigs or horses ([l] unpublished). We now report a search for the evolutionary origin of this lipase. Two possibilities were considered: (i) The lipase might have evolved through a mutational change of some other milk protein; (ii) It might be a secretory protein from some other tissue which through a change in gene regulation has become expressed also by the milk producing cells. The results presented show that the lipase is closely related to a pancreatic protein but not to any of the other milk proteins.


Nutrition and Cancer | 1982

Fecal sterols and bacterial β‐glucuronidase activity: A preliminary metabolic epidemiology study of healthy volunteers from Umea, Sweden, and metropolitan New York

Lennart Domellöf; Loretta Darby; Debra Hanson; Laurel Mathews; Barbara Simi; Bandaru S. Reddy

The dietary pattern, fecal bile acid and neutral sterol concentrations, and the bacterial beta-glucuronidase activity of 2 population groups with a varied risk for colon cancer development (i.e., a high-risk population in the metropolitan New York area and an intermediate-risk population in Umea, Sweden) were investigated. The average daily intake of dietary protein was the same in the 2 groups, but the fat intake was higher in Umea than in New York. The daily total fiber intake was also higher in Umea, as was the daily total stool output. The concentration of fecal secondary bile acids and beta-glucuronidase activity was lower in Umea than in New York, but the total daily excretion of these constituents was the same in both groups. The data suggest that one of the factors contributing to the lower risk of colon cancer in Umea, despite the high dietary fat intake, is the high intake of dietary whole grain and cereal fiber, which leads to an increase in stool bulk, thus diluting and/or binding promoters.


Scandinavian Journal of Gastroenterology | 1978

The development of mucosal changes after gastric surgery for ulcer disease.

Janunger Kg; Lennart Domellöf; Sune Eriksson

The development of morphological changes in the body mucosa after partial gastrectomy for ulcer disease according to Billroth I and II was studied early (within 3 years) and late (10-24 years) postoperatively with gastroscopy and forceps biopsies. The morphological findings in the body mucosa of the operation specimens and biopsies from the stomas were compared. The effect of time, ulcer disease, operation procedure, sex, and age was studied. In duodenal ulcer patients, with significantly less pronounced inflammatory mucosal changes in the operation specimen, partial gastrectomy caused acute and chronic gastritis to the same degree as seen in gastric ulcer patients within 3 years postoperatively. Duodenal ulcer patients also developed mucosal atrophy, cystic dilatation of the gastric glands, and intestinal metaplasia by time to an extent not significantly different from what was found in gastric ulcer patients. No correlation could be found between the mucosal changes and factors like age, sex, or operation procedure. Mucosal atrophy, chronic gastritis, and intestinal metaplasia are regarded as possible features of malignant transformation. If this concept is true, our findings may explain why stump carcinoma is frequently reported with the same incidence independent of preoperative ulcer disease or anastomotic procedure.


Nutrition and Cancer | 1983

Metabolie epidemiology of colon cancer: Dietary pattern and fecal sterol concentrations of three populations

Bandaru S. Reddy; Göran Ekelund; Måns Bohe; Althea Engle; Lennart Domellöf

The nutrient intake, fecal neutral sterol concentration, and bile acid concentration of populations with a varied risk for colon cancer development were investigated. High-risk populations in the metropolitan New York area and Malmo, Sweden, were compared with an intermediate-risk population in Umea, Sweden. The mean daily intake of protein and fat was comparable in all groups, but the total daily fiber intake was higher in Umea, as was the total daily stool output. There was no difference in the total fiber intake and stool output between Malmo and metropolitan New York. The fecal secondary bile acid concentration was lower in Umea than in the other two areas; no difference was observed between Malmo and metropolitan New York. These results suggest that high fiber intake may be considered protective against colon cancer even in a population with a high risk intake. A high dietary fiber intake may limit colon cancer risk by increasing stool bulk, and thus diluting and/or binding tumor promoters.


American Journal of Surgery | 1981

Effect of bile acid gavage or vagotomy and pyloroplasty on gastrointestinal carcinogenesis

Lennart Domellöf; Sune Eriksson; Hideki Mori; John H. Weisburger

Possible promotion of MNNG-induced gastrointestinal carcinogenicity was evaluated in male Wistar rats exposed to unconjugated bile acid given as gavage or as obtained through truncal vagotomy plus pyloroplasty. No significant difference was found compared with the relevant control groups. Even though gastroduodenal erosions were found more frequently in the bile acid gavage and MNNG groups than in MNNG-treated controls, secondary deconjugated bile acids apparently did not reach optimal promoting concentrations. In contrast to partial gastrectomy, vagotomy and pyloroplasty does not increase the tumor yield in the rat.


Scandinavian Journal of Urology and Nephrology | 1975

Dysplasia of the testis and epididymis.

Gunnar Lingårdh; Lennart Domellöf; Sune Eriksson; Bengt Fåhraeus

Various congenital malformations of the testis and the seminal pathways are illustrated by 10 cases. Though these malformations are often free from symptoms, an increasing number of them are now being discovered in connection with investigations of male infertility. In cases of azoospermia where testicular biopsies show complete spermatogenesis, surgical exploration is indicated. Some of these malformations may then be treated by surgery, with fairly good prospects of restored fertility.


European Journal of Clinical Pharmacology | 1985

The phagocytosis of yeast cells by blood monocytes. Effects of therapeutic concentrations of vinca alkaloids

Leif Athlin; Lennart Domellöf; Bo Norberg

SummaryThe role of cytoplasmic microtubules in the phagocytosis of yeast cells by blood monocytes was studied by means of therapeutic concentrations of the Vinca alkaloids vincristine, vinblastine, and vindesine.Phagocytosis was measured in a monolayer of glass-adherent monocytes fed with fluorescein-labelled yeast cells.Phagocytosis was composed of two sequential processes, yeast cell adherence to the monocyte and yeast cell engulfment by the monocyte.Monocyte phagocytosis was significantly inhibited by the Vinca alkaloids, mainly due to inhibition of engulfment but probably also due to inhibition of adherence.Since the Vinca alkaloids are microtubule antagonists it is reasonable to assume that monocyte phagocytosis, both adherence and engulfment, are partially microtubule-dependent processes.It is suggested that Vinca alkaloid inhibition of monocyte phagocytosis is of value in the treatment of type II–III autoimmune disorders, such as idiopathic thrombocytopenic purpura and autoimmune haemolytic anaemia.

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