Lennart Friis

High exposures to organic solvents among graffiti removers

SummaryThe exposure to organic solvents among 12 graffiti removers was studied. Health effects were also assessed by structured interview and a symptom questionnaire. Blood and urine samples were collected at the end of the day of air sampling. The concentrations of dichloromethane, glycol ethers, trimethylbenzenes and N-methyl-2-pyrrolidinone in the breathing zone of each worker were measured during one working day. The 8-h time-weighted average exposure to dichloromethane ranged from 18 to 1200 mg/m3. The Swedish Permissible Exposure Limit value for dichloromethane is 120 mg/m3. The air concentrations of glycol ethers, trimethylbenzens and N-methyl-2-pyrrolidinone were low or not detectable. No exposure-related deviations in the serum concentrations of creatinine, aspartate transaminase, alanine transaminase, γ-glutamyl transpeptidase or hyaluronan or the urine concentrations of α1-microglobulin, R2-microglobulin or N-acetyl-β-glucos-aminidase were found. Irritative symptoms of the eyes and upper respiratory tract were more prevalent than in the general population. This study demonstrates that old knowledge about work harzards is not automatically transferred to new professions. Another aspect is that the public is also exposed as the job is performed during daytime in underground stations. At least for short periods, bystanders may be exposed to high concentrations of organic solvent vapours. People with predisposing conditions, e.g. asthmatics, may risk adverse reactions.

Self-Reported Asthma and Respiratory Symptoms in Sewage Workers

Self‐Reported Asthma and Respiratory Symptoms in Sewage Workers: Lennart Friis, et al. Department of Occupational and Environmental Medicine University Hospital, Uppsala, Sweden—To investigate whether Swedish sewage workers have an increased risk of respiratory symptoms or diseases. In a cross‐sectional study, 149 sewage workers and 138 referents, selected from among other municipal workers, were given a self‐administered questionnaire about asthma, atopy, smoking and symptoms from the airways, skin and eyes. Two‐by‐two statistics was used to compare proportions and logistic regression was used for multivariable analyses. The sewage workers reported significantly more adult asthma than the referents. The adjusted odds ratio for asthma during adulthood was 5.3 (95% confidence interval 1.1‐26) as determined from a multivariable logistic regression analysis when controlling for age, gender, atopic disposition and tobacco smoking. They also had increased risk, but not statistically significant, of some possibly asthma related symptoms and chronic bronchitis. There was no difference in atopic disposition based on a history of allergic diseases in childhood or in parents. Neither were there any differences in symptoms in the eyes or skin. Self‐reported asthma was more common among the sewage workers than other municipal workers. This might be caused by occupational exposure to irritant or inflammatory substances.

Mortality and incidence of cancer among sewage workers : a retrospective cohort study

To study the incidence of and mortality from cancer among sewage workers a retrospective analysis was performed on a cohort of 656 men employed for at least one year at any one of 17 Swedish sewage plants during the years 1965-86. Assessment of exposure was done by classification of work tasks. Lower than expected total mortality (standardised mortality ratio (SMR) = 0.75, 95% confidence interval (95% CI) 0.58-0.97) and cardiovascular mortality (SMR = 0.61, 95% CI 0.39-0.91) was found. This was interpreted as a result of the healthy worker effect. For all cancers combined the mortality (SMR = 1.08, 95% CI 0.68-1.67) and morbidity (SMR = 1.02, 95% CI 0.72-1.38) were comparable with those of the general population. There were increased incidences for brain tumours (SMR = 2.19, 95% CI 0.45-6.39), gastric cancers (SMR = 2.73, 95% CI, 1.00-5.94), and renal cancers (SMR = 1.68, 95% CI = 0.35-4.90). For lung cancer the risk was reduced (SMR = 0.70, 95% CI 0.15-2.05). Allowance for a latency period of 10 years from the start of exposure did not change the pattern. Logistic modelling was used to search for exposure-response relations. In a logistic model with the confounder age forced in, renal cancer had a significant positive relation with a weighted sum of employment times, where the weights describe the classification of exposure. No exposure-response relations were found for brain tumors or gastric cancers. The increased risks are based on small numbers of cases. A future follow up will add more conclusive power to the study. Specific exposures need to be identified to allow for a better dose-response analysis.

Validation of a geologically based radon risk map: are the indoor radon concentrations higher in high-risk areas?

Since geographically coded information is frequently used in studies of the relationships between environmental factors and illness at the population level and by authorities for promotion of mitigation, knowledge about the validity of proxy measures is essential. This study was an evaluation of a geologically based map describing the risk for high radon levels, which was used by the municipal authorities to determine the necessity of remedial actions. Annual mean radon gas concentrations for a random sample of one-family homes selected from high-risk areas (n = 252) were compared with those of a random sample of homes from normal and low-risk areas (n = 259). No difference in geometric mean radon concentration was found between the areas, 101 Bq m(-3) and 103 Bq m(-3), respectively. The proportion of homes in each area with radon gas concentrations above the current Swedish administrative limit value for mitigation (400 Bq m(-3)) was similar, approximately 10%. We conclude that the radon risk map was unsuitable for identifying areas of concern. The findings also indicate that geologically based and geographically coded information as a proxy for human exposures can be safely used for scientific and administrative purposes only following validation.