Leon Fuks

Labelling of peptides with 99mTc complexes through the modified C-terminal group

Easy and efficient way to modify of the C-terminus of the peptide using amino acid lysine has been proposed and experimentally verified. The synthesis yield was high (≥85%) and it was found that reactions can be carried out even with microgram amounts of the peptide. Using Fmoc-alanine (as the peptide model) with modified C-terminus the procedure of peptide labelling with monovalent and trivalent 99mTc complexes has been elaborated.

Sorption of Sr-85 and Am-241 from liquid radioactive wastes by alginate beads

Abstract The paper reports the adsorption of strontium(II) and americium(III) from aqueous solutions onto calcium alginate (CaA), barium alginate (BaA) and strontium alginate (SrA) beads. Adsorption process was studied in batch experiments as a function of the initial pH of the solution and the contact time. All sorbents were examined by the termogravimetric analysis (TG). Laboratory obtained spherical beads of CaA, BaA and SrA seem to be good metal sorbents from liquid radioactive wastes. A contact time of about 4 h and neutral pH of the initial aqueous solution have been proposed to be optimum conditions for Sr-85 and Am-241 removal from the contaminated solutions using alginate sorbents. Laboratory obtained beads of CaA, BaA and SrA are characterized by the decontamination factor (DF) equal to 85% for Sr(II) and 90% for Am(III).

Technetium(I) tricarbonyl complexes: potential precursors of the radiopharmaceuticals. Part II: phenethylbiguanide (phenformin)

The radiosynthesis of [99mTc]-phenformin ([99mTc]-1-phenethylbiguanide) complex and its suitability as precursor of the radiopharmaceuticals for the tumor imaging was assessed. Radiochemical purity of the [99mTc]-complex was determined using radio-TLC and was studied by the HPLC with radiochemical detection, while its stability in challenge experiments. The results show, that due to the sufficient stability and lipophilicity of the complex, it fulfills our expectations for promising radiopharmaceutical precursor not only for the diagnostic agent, but also for the drug suitable for the oncological Auger electron therapy.