Leonard Cortese

One year outcome in first episode psychosis: influence of DUP and other predictors

BACKGROUND A number of studies have reported evidence of a relationship between longer duration of untreated psychosis (DUP) and poorer outcome at 1 year while others have failed to find such evidence. It is possible that several other predictors may confound this relationship and there may be different predictors for different dimensions of outcome. In the current study we examined relationship between DUP and several other predictors, and 1 year outcome on rate and level of remission as well as level of positive, negative, depressive and anxiety symptoms in a community cohort of first episode psychosis patients. METHOD All potential cases of a first episode of non-affective psychosis were assessed and offered treatment in a comprehensive treatment program. Data were collected on all patients who completed 1 year of treatment on a number of predictor variables (DUP, length of the prodromal period, age of onset, gender, pre-morbid adjustment during childhood and adolescence, diagnosis) and outcome variables (level of remission, positive, negative, depression and anxiety symptoms based on ratings on SAPS, SANS, CDS and HAS, respectively). Data were analysed using an analysis of variance, bivariate correlations and hierarchical regression analysis. RESULTS Of a total of 130 patients were offered treatment, 106 completed 1 year of treatment and complete data were available on 88 subjects, 80% of whom met criteria for schizophrenia spectrum psychosis. The rate and level of remission were significantly higher for patients with shorter DUP (<22 weeks). DUP was the only independent predictor of the level of remission as well as reality distortion at 1 year; for disorganization syndrome and negative symptoms it was the age of onset and level of premorbid adjustment in adolescence, respectively; while the level of anxiety was predicted by the length of the prodrome. Additional predictors increased the variance explained by each model. CONCLUSION Our results confirmed the independent role of DUP in remission and positive symptom outcome at 1 year, thus providing support for the enthusiasm for early intervention. However, the model including DUP and premorbid adjustment in early adolescence explained a greater amount of variance in outcome on positive symptoms than DUP alone. On the other hand, outcome on negative symptoms, disorganization and anxiety are more likely to be influenced by longer term characteristics such as premorbid adjustment, earlier age of onset, gender and the length of the prodromal period, and therefore may not be as responsive to effects of early intervention.

The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale

Objective: Reports suggesting that quality of life in schizophrenia is more highly related to negative rather than positive symptoms are largely based on use of the Quality of Life Scale which was devised to assess deficit symptoms and does not include an assessment of subjective general wellbeing. In the current paper we examined symptoms, level of community functioning as well as living circumstances as correlates of Quality of Life Scale scores and scores on the General Well‐Being Scale.

Three syndrome concept of schizophrenia: A factor analytic study

One hundred and fifty-five DSM-IIIR schizophrenic patients were assessed for positive and negative symptoms using Andreasens Scale for Assessment of Positive Symptoms (SAPS) and the Scale for Assessment of Negative Symptoms (SANS). Interrelationships of individual positive and negative symptoms were examined using a factor analysis. Results of the factor analysis are consistent with Liddles proposition that there are three syndromes underlying symptomatology in schizophrenia: disorganization; psychomotor poverty and reality distortion.

Negative symptoms in first episode non-affective psychosis

Objective: To determine the prevalence of negative symptoms and to examine secondary sources of influence on negative symptoms and the role of specific negative symptoms in delay associated with seeking treatment in first episode non‐affective psychosis.

A study of the interrelationship between and comparative interrater reliability of the SAPS, SANS and PANSS

We assessed the comparative interrater reliability of the SANS/SAPS and PANSS as measures of symptomatology in schizophrenia and also examined the interrelationship between scores on these instruments. Two experienced raters used these Scales to assess positive and negative symptoms in a group of 85 patients with a DSM III-R diagnosis of schizophrenia. Ratings were based on structured clinical interviews, review of case notes and consultation with staff familiar with the patients. Comparable levels of interrater reliability were found for each system of measuring symptomatology, but levels of interrater reliability were on the whole lower than have been reported in the past. There were high correlations between overall indices of positive and negative symptomatology derived from the two measurement systems.

Relationship between neurological 'soft signs’and syndromes of schizophrenia

Past research on the importance of soft’neurological signs in schizophrenia has often not examined the relationship between specific groups of neurological signs and different dimensions of schizophrenia psychopathology. Gender differences in the reported relationships have never been explored. In this paper we describe a study of 100 DSM‐III‐R (65 male and 35 female) schizophrenic patients who were rated for neurological soft signs’with the Neurological Evaluation Scale (NES) (1), and for schizophrenic symptomatology with the Scale for Assessment of Negative Symptoms (SANS) and the Scale for Assessment of Positive Symptoms (SAPS). Following a factor analysis of NES items, differential relationships were examined between the five derived NES factors and three well‐established dimensions of schizophrenic symptomatology, namely psychomotor poverty, disorganization and reality distortion. Our results failed to show any relationship between NES dimensions and either the reality distortion or disorganization dimensions. There was a modest but differentially significant relationship between psychomotor poverty and an extrapyramidal factor on the NES. This relationship was shown only by male subjects, and was influenced by duration of illness but not by age or neuroleptic medication. On the other hand, female subjects showed a significant relationship between psychomotor poverty and an NES factor reflecting attention and initiative, and between reality distortion and coordination/sequencing of motor activity. These relationships in female subjects were, relative to relationships for male subjects, more independent of the effect of medication and duration of illness.

The relationship between types of anxiety and depression.

There has been considerable debate about the relationship between anxiety and depression. Most of the research in this area has examined relationships between composite indices of each construct. It has been suggested, however, that social anxiety may be more highly related to depression than are other forms of anxiety. We report the results of a study of the differential relationship of anxiety related to three sources (social evaluation, physical danger, and unfamiliar situations) to both self-report and clinician-rated levels of depression in a sample of 117 psychiatric outpatients. The results indicate that anxiety concerning social evaluation and unfamiliar situations was more highly related to depression than anxiety about physical danger.