Leonardelli Gb

[Solitary extracranial neurilemmomas of the head; anatomo-clinical study of 16 cases].

16 cases of extracranial solitary neurilemmomas localized to the head and neck (middle ear, nose, parotid gland, lip, tongue, cheek, alveolar margin, laterocervical and frontoparietal regions) are referred. From an anatomopathological standpoint it is mainly underlined: 1) the opportunity of considering two types only (benign and malignant neurilemmoma), as the Anthonis « B» type results to be conditioned by regressive-involutive phenomena which easily occur in classical « A» neurilemmomas with active growth; 2) the rare and aspecific palisade arrangement of the tumour elements which, however, often occurs in other neoplasms (fibromas, myomas, fibrosarcomas, ablastic sarcomas, etc.); 3) the difficult recognition of the malignant varieties which frequently show histoarchitectonic as well as histocytologic hyperdifferentiation; so the biological malignancy of the tumour is based more on clinical than on histo-cytological aspects. From a clinical standpoint, it is emphasized: 1) the seldom incidence of the extracranial solitary neurilemmoma at the level of the cephalic sector (derived from the analysis of more than 60,000 bioptical examinations) ; 2) the highest frequency in the 4th-5th decade of life, in female sex, and in oral and nasal regio,ns; 3) the aspecificity of the symptomatological picture which is common to other neoplastic, dysplastic and phlogistic processes of this region, leading to difficulties of the diagnosis, which is relied upon the intraoperative microscopical observation; 4) the determinant value of an early and radical surgical treatment for a definitive clinical recovery.

Pseudoneoplastic aspects in chronic phlogosis of lymphocytic type of the parotid gland

9 cases of lymphocitary chronic nodular phlogosis of the parotid gland are studied. The different pathogenetic factors are discussed and the relationship with Hashimoto thyroiditis (histologically similar) is examined. On the basis of microscopical investigations, showing the presence of intraparotidean lymphnodes (including salivary epithelial elements), these « pseudo-tumoral nodular hyperplastic » aspects are suggested to be derived from chronic phlogistic hyperplasy of the pre-existent lymphnodes. The morphological alterations of the parotidean glandular elements and the eventual malignant transformation are pointed out.

[The significance of giant follicular lymphadenopathy (so-called Brill-Symmers disease); histopathological contribution and critical considerations].

Sulla scorta di personali osservazioni –- una delle quali controllata autopticamente –- condotte su linfonodi iperplastici tributari di territori sedi di processi flogistici cronici, gli AA. pongono in rilievo come gli aspetti istologici della linfopatia giganto-follicolare (l.g.f.) –- gia considerati peculiari di quella affezione che va sotto il nome di « malattia di Brill-Symmers » –- siano invece reperibili anche in forme di linfopatie circoscritte croniche aspecifiche, di natura tossi-infettiva.Analogamente sono da ritenersi –- secondo gli AA. –- quei quadri microscopici che si riscontrano talora nelle linfoghiandole tributarie di organi colpiti da tumore epiteliale maligno: si tratta di una delle varie condizioni « premetastatiche » aspecifiche sostenute non da stimoli oncogeni, ma da stimoli cronici tossici secondari alle turbe metaboliche indotte dalle aree di necrosi del tessuto neoplastico.Sulla scorta di personali osservazioni –- una delle quali controllata autopticamente –- condotte su linfonodi iperplastici tributari di territori sedi di processi flogistici cronici, gli AA. pongono in rilievo come gli aspetti istologici della linfopatia giganto-follicolare (l.g.f.) –- gia considerati peculiari di quella affezione che va sotto il nome di « malattia di Brill-Symmers » –- siano invece reperibili anche in forme di linfopatie circoscritte croniche aspecifiche, di natura tossi-infettiva.Analogamente sono da ritenersi –- secondo gli AA. –- quei quadri microscopici che si riscontrano talora nelle linfoghiandole tributarie di organi colpiti da tumore epiteliale maligno: si tratta di una delle varie condizioni « premetastatiche » aspecifiche sostenute non da stimoli oncogeni, ma da stimoli cronici tossici secondari alle turbe metaboliche indotte dalle aree di necrosi del tessuto neoplastico.

[Attempts at the experimental induction of tumors of lymphatic tissue. I. Trials with ACTH and acetyl-2-fluorenamine].

A lymphocytolytic hormone (ACTH) and a carcinogenic substance with general and protrected action (AAF) were administared to rats in order to induce hyperdysplastic-neoplastic processes in the lymphatic tissue. Microscopical examinations were performed (at different time intervals) on some organs (liver, spleen, thymus, testis, intestine, kidney, adrenals, lymph nodes) of the animals treated with the carcinogen alone as well as of those treated by the combined administration ACTH + AAF. High dosage (50 U.I. pro die for 10 days) of ACTH did not induce proliferative changes in the lymphatic tissue, except for a slight hyperplasia. True preneoplastic changes were obtained only in the liver of animals submitted to combined treatment.A lymphocytolytic hormone (ACTH) and a carcinogenic substance with general and protrected action (AAF) were administared to rats in order to induce hyperdysplastic-neoplastic processes in the lymphatic tissue. Microscopical examinations were performed (at different time intervals) on some organs (liver, spleen, thymus, testis, intestine, kidney, adrenals, lymph nodes) of the animals treated with the carcinogen alone as well as of those treated by the combined administration ACTH + AAF. High dosage (50 U.I. pro die for 10 days) of ACTH did not induce proliferative changes in the lymphatic tissue, except for a slight hyperplasia. True preneoplastic changes were obtained only in the liver of animals submitted to combined treatment.

[Attempts at the experimental induction of tumors of lymphatic tissue. II. Trials with methyl-bis-beta-chloroethylamine and acetyl-2-fluorenamine].

An atypical proliferation of the lympatic tissue has been obtained in rats by the combined administration of a lymphocytolytic substance (methyl-bis-beta-chloro-ethylamine) and a carcinogenic substance (acetaminofluorene).