Lester M. Morrison

Reduction of mortality rate in coronary atherosclerosis by a low cholesterol-low fat diet☆☆☆

Abstract 1. 1. One hundred patients with recent recovery from proved coronary thrombosis and myocardial infarction were studied over a three-year period as to the effect of a low cholesterol-low fat diet on the mortality and morbidity rates. 2. 2. Fifty consecutive patients were placed on a daily 20 to 25 Gm. fat diet, and fifty alternate control patients were observed on the “normal” prethrombosis diet. 3. 3. It was found that there was a trend toward a reduction in mortality and morbidity rates in coronary atherosclerotic patients on a 20 to 25 Gm. daily cholesterol-fat diet.

Results of treatment of coronary arteriosclerosis with choline

Abstract 1. 1. A series of 115 patients with proved coronary thrombosis and myocardial infarction were treated with choline for periods of one to three years after recovery from the immediate attack. These patients were compared to 115 control patients who were alternately admitted to the hospital with the same diagnosis but who did not receive choline treatment. 2. 2. The dosage of oral choline averaged 12 grams daily. It was taken for one year by 52 subjects, for two years by 35 subjects and for three years by 28 subjects. 3. 3. The subsequent mortality rate of patients who had suffered an acute coronary thrombosis with myocardial infarction appeared to be significantly reduced by the treatment with choline in this series of patients. 4. 4. These studies suggest that the lipotropic agent choline is of value in the treatment of coronary arteriosclerosis and would appear to merit further trial and observation in this disease.

Cholesterol content of the coronary arteries and blood in acute coronary artery thrombosis.

Abstract 1. 1. The average cholesterol content of the coronary arteries in a group of patients who died from an acute coronary artery thrombosis was four times as great as the average cholesterol content of the coronary arteries in a comparable group of control patients. 2. 2. Hypercholesterolemia was found in most of the patients who died of acute coronary artery thrombosis, as compared to a normal blood cholesterol average in the comparable control group. 3. 3. These findings suggest that a disturbance in lipid metabolism is a factor in the pathogenesis of atherosclerosis.

Absence of naturally occurring coronary atherosclerosis in squirrel monkeys ( Saimiri sciurea ) treated with chondroitin sulfate A

Die überraschende Atheromatosehemmende Wirkung von Chondroitin-Sulfat konnte nun auch beiSaimiri scurea, einem Primaten mit hoher Inzidenz von Atheromatose, nachgewiesen werden.

A precipitin test for serum lipoproteins in human coronary atherosclerosis

Significant differences in response to the precipitin test as based on human serum lipoproteins were demonstrated between atherosclerotic cases and controls. These differences were not influenced by the sex of the subjects.