Letteria Spadaro

Tele-Health and neurology: what is possible?

Emerging information and communication technology is changing medical and psychological practice by enabling the provision of services across time and distance, yet there are significant concerns about these applications. Given the emerging nature of trial evidence in teleneurology, our aim is to provide a narrative review, in order to investigate possible oncoming fields of applications that are very important in healthcare practices delivered to patients affected by neurological diseases. We will focus on the use of Tele-Health in neurological practice, highlighting the potential benefits of applying information and communication technology also to psychosocial and educational aspects of neurological diseases treatment. This work is based on PubMed search, manual search of published abstracts/conference proceedings, and consultation with investigators in neurological disease. We refer also to the broader Tele-Health research concerning mental diseases. Tele-Health has obvious advantages in rural areas, where it improves access to health services, obviating the need for patients and healthcare workers to travel and assuring continuance to healthcare services delivery. Even in urban areas, however, Tele-Health can improve access to health services and to information. It may sometimes also be cheaper than conventional practice, even if there is generally limited knowledge of the cost-effectiveness of Tele-Health services compared to conventional methods of delivering health services.

Fahr's Disease Presenting with Dementia at Onset: A Case Report and Literature Review

Fahrs disease (FD) is characterized by sporadic or familiar idiopathic calcification of the basal ganglia, dentate nuclei of the cerebellum, and centrum semiovale, mainly presenting with movement disorder, dementia, and behavioral abnormalities. We described a rare case of Fahrs disease presenting at onset only with behavioral and neuropsychological alterations, whose diagnosis was supposed only after a brain CT, which showed extensive bilateral calcifications in the dentate nuclei of the cerebellum and basal ganglia. Since the onset of Fahrs disease may be a dysexecutive syndrome with behavioral abnormalities, the clinical and radiological features are really important to do the appropriate diagnosis.

Improving Cognitive Function in Patients with Stroke: Can Computerized Training Be the Future?

BACKGROUND Cognitive impairment after stroke is common and can cause disability with a high impact on quality of life and independence. Cognitive rehabilitation is a therapeutic approach designed to improve cognitive functioning after central nervous systems injuries. Computerized cognitive rehabilitation (CCR) uses multimedia and informatics resources to optimize cognitive compromised performances. The aim of this study is to evaluate the effects of pc cognitive training with Erica software in patients with stroke. METHODS We studied 35 subjects (randomly divided into 2 groups), affected by either ischemic or hemorrhagic stroke, having attended from January 2013 to May 2015 the Laboratory of Robotic and Cognitive Rehabilitation of Istituto di Ricerca e Cura a Carattere Scientifico Neurolesi in Messina. Cognitive dysfunctions were investigated through a complete neuropsychological battery, administered before (T0) and after (T1) each different training. RESULTS At T0, all the patients showed language and cognitive deficits, especially in attention process and memory abilities, with mood alterations. After the rehabilitation program (T1), we noted a global cognitive improvement in both groups, but a more significant increase in the scores of the different clinical scales we administered was found after CCR. CONCLUSIONS Our data suggest that cognitive pc training by using the Erica software may be a useful methodology to increase the post-stroke cognitive recovery.

Cerebrovascular Diseases: Post-stroke Depression and Anhedonia

Increasing interest in depression within acute and chronic cerebrovascular pathology is justified for its clinical relevance, since its identification and management is of use in reducing disability, the caregiver’s burden and the social-economic impact of cerebrovascular disease. Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression, schizophrenia and other neuropsychiatric disorders, including cerebrovascular disorders. Since stroke survivors frequently suffer from depression, research has focused on the incidence, phenomenology, course and risk factors of post-stroke depression (PSD), paying special attention to the biological explanatory models, such as the lesion location and vascular depression hypotheses. Small vessel pathology and microvascular lesions are no longer considered as minor players in the fields of cognitive impairment and mood regulation. Unlike cognition, the relationship between these lesions and mood dysregulation is still a matter of intense debate. However, the chronic accumulation of lacunes in thalamus, basal ganglia and deep white matter has been recently considered as a strong correlate of PSD.

An initial validation of the Italian Mishel Uncertainty Illness Scale (MUIS) for relapsing remitting multiple sclerosis patients

Multiple sclerosis is a chronic disease, likely to condition patients’ daily living and quality of life: given the unpredictability of frequency and severity of the attacks, patients experience a high level of uncertainty. While there have been many analyses whose purpose was to monitor multiple sclerosis (MS) patients’ quality of life, the role of uncertainty, that is peculiar to the disease, has not been adequately considered so far. The present study is aimed at filling this gap by validating for Italian MS patients the Mishel’s Uncertainty Illness Scale (MUIS). The MUIS has been developed in the USA context in order to assess four aspects of uncertainty: ambiguity, complexity, inconsistency and unpredictability. It has been largely applied in the cancer, cardiac and chronic illness population. Data employed in this study have been collected at two neurological centres in Messina (IRCCS Centro Studi Neurolesi “Bonino Pulejo” and Policlinico di Messina) in the first semester of 2013 and refer to 120 MS patients. The confirmatory factor analysis described in this study validates two of the four dimensions of MUIS, namely ambiguity and inconsistency. The validation, though partial, of the MUIS, allows the use of this instrument in studies investigating quality of life for Italian patients.

Cortical reorganization in multiple sclerosis after intrathecal baclofen therapy

Our objective was to assess the role of Intrathecal Baclofen Therapy (ITB) in the cortical reorganization in a patient affected by multiple sclerosis (MS) undergoing physical therapy. We reported a case of a woman affected by MS and severe spasticity, who performed an fMRI examination, before and after the ITB implantation. The subject showed controlateral motor cortex activation after motor task. After a month of ITB implantation, patient showed ipsilateral and controlateral motor cortex activation although with a broader extension. fMRI examination supported the hypothesis of a central influence in patients who undergo physiotherapy and therapy with ITB.

Advances in the Treatment of MELAS Syndrome: Could Cognitive Rehabilitation Have a Role?

Mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes syndrome (MELAS) is a rare inherited mitochondrial disorder, commonly due to the m.3243A>G mutation, which typically presents with seizures, headaches, and acute neurological stroke-mimicking deficits. At onset, there is often no general intellectual deterioration in these patients, although specific cognitive deficits in peculiar language domains, visual construction, attention, abstraction, or flexibility may be present. To date, there is no evidence for an effective treatment in individuals with MELAS. Herein, we describe the case of young woman affected by MELAS who underwent an intensive cognitive training by means of the following methods: (a) traditional cognitive training, (b) computerized cognitive training (CCT), and (c) CCT plus a low-intensity aerobic motor exercise. We compared her cognitive and psychological profile at baseline (T0) and at the end of each training (i.e., (Time 1, Time 2, and Time 3 [T3]) using a proper psychometric battery, and we found a greater improvement at T3. Our findings support the idea that the combined CCT with motor training could represent a valuable therapeutic opportunity in MELAS.

Agenesis of Corpus Callosum and Frontotemporal Dementia A Casual Finding

Agenesis of corpus callosum (AgCC) is a congenital malformation characterized by total or partial absence of corpus callosum with a good neuropsychological profile. Frontotemporal dementia (FTD) is the third most common cause of cortical dementia, and it is characterized by alterations in personality and social relationship, often associated with deficits in attention, abstraction, planning, and problem solving. Herein, we report a case of a 73-year-old woman presenting with FTD associated with primary AgCC. The possible “causal or casual” relationship between these 2 different conditions should be investigated in large prospective studies.