Leyang Zhang
Nanjing University
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Publication
Featured researches published by Leyang Zhang.
Biomaterials | 2003
Yong Hu; Xiqun Jiang; Yin Ding; Leyang Zhang; Changzheng Yang; Junfeng Zhang; Jiangning Chen; Yonghua Yang
Amphiphilic block copolymers, poly(caprolactone)-poly(ethylene glycol)-poly(lactide) (PCELA), were synthesized by ring opening polymerization of caprolactone and lactide initiated with the hydroxyl groups of poly(ethylene glycol) (PEG). These copolymers could form micelle-like nanoparticles due to their amphiphilic characteristic. From the observation of transmission electron microscopy (TEM), the nanoparticles exhibited a regular spherical shape with core-shell structure. The critical micelle concentrations (CMC) of these nanoparticles in water were decreased as molecular weight of PEG decreased. The particle sizes obtained by dynamic light scattering of these nanoparticles were in the range of 100-200 nm, and increased as the hydrophobic property of the nanoparticles increased. Nimodipine as a model drug was loaded in these nanoparticles to investigate the drug release behavior. It was found that the chemical composition of the nanoparticles was a key factor in controlling nanoparticle size, nanoparticle yields, drug-entrapment efficiency, and drug release behavior. When the PEG content is about 2% (wt), the release profile of PCELA nanoparticles appeared to follow zero-order kinetics.
Small | 2009
Rui Guo; Rutian Li; Xiaolin Li; Leyang Zhang; Xiqun Jiang; Baorui Liu
An effective and facile approach to prepare gold-nanoparticle-encapsulated alginic acid-poly[2-(diethylamino)ethyl methacrylate] monodisperse hybrid nanospheres (ALG-PDEA-Au) is developed by using monodisperse ALG-PDEA nanospheres as a precursor nanoparticulate reaction system. This approach utilizes particle-interior chemistry, which avoids additional reductant or laborious separation process and, moreover, elegantly ensures that all the gold nanoparticles are located inside the hybrid nanospheres and every nanosphere is loaded with gold nanoparticles. These obtained ALG-PDEA-Au hybrid nanospheres have not only uniform size, similar surface properties, and good biocompatibility but also unique optical properties provided by the embedded gold nanoparticles. It is demonstrated that negatively charged ALG-PDEA-Au hybrid nanospheres can be internalized by human colorectal LoVo cancer cells and hence act as novel optical-contrast reagents in tumor-cell imaging by optical microscopy. Moreover, these hybrid nanospheres can also serve as biocompatible carriers for the loading and delivery of an anti-cancer drug doxorubicin. In vitro cell viability tests reveal that drug-loaded ALG-PDEA-Au hybrid nanospheres exhibit similar tumor cell inhibition to the free drug doxorubicin. Therefore, the obtained hybrid nanospheres successfully combine two functions, that is, cell imaging and drug delivery, into one single system, and may be of great application potential in other biomedical-related areas.
Macromolecular Bioscience | 2011
Rui Guo; Yuan Cheng; Dan Ding; Xiaolin Li; Leyang Zhang; Xiqun Jiang; Baorui Liu
Surfactant-free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM-based pharmaceutical agents.
Journal of Controlled Release | 2004
Leyang Zhang; Yong Hu; Xiqun Jiang; Changzheng Yang; Wei Lu; Yong Hua Yang
Journal of Controlled Release | 2007
Leyang Zhang; Mi Yang; Qin Wang; Yuan Li; Rui Guo; Xiqun Jiang; Changzheng Yang; Baorui Liu
Biomacromolecules | 2007
Yong Hu; Yin Ding; Dan Ding; Mingjie Sun; Leyang Zhang; Xiqun Jiang; Changzheng Yang
Biomacromolecules | 2004
Yong Hu; Leyang Zhang; Yi-yi Cao; Haixiong Ge; Xiqun Jiang; Changzheng Yang
Angewandte Chemie | 2004
Yin Ding; Yong Hu; Xiqun Jiang; Leyang Zhang; Changzheng Yang
Biomacromolecules | 2006
Yin Ding; Yong Hu; Leyang Zhang; Ying Chen; Xiqun Jiang
Polymer | 2005
Yong Hu; Ying Chen; Qi Chen; Leyang Zhang; Xiqun Jiang; Changzheng Yang