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Dive into the research topics where Li-Na Jia is active.

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Featured researches published by Li-Na Jia.


Chemical Communications | 2011

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

Liang-Liang Wang; Lin Peng; Jian-Fei Bai; Li-Na Jia; Xi-Ya Luo; Qing-Chun Huang; Xiao-Ying Xu; Li-Xin Wang

An effective double Michael reaction has been disclosed to access spirocyclic oxindoles in high yields (up to 98%) and excellent enantioselectivities (up to 98% ee).


Journal of Organic Chemistry | 2012

Asymmetric Michael Addition of α-Substituted Isocyanoacetates with Maleimides Catalyzed by Chiral Tertiary Amine Thiourea

Jian-Fei Bai; Liang-Liang Wang; Lin Peng; Yunlong Guo; Li-Na Jia; Fang Tian; Guang-Yun He; Xiao-Ying Xu; Li-Xin Wang

A highly diastereoselective and enantioselective Michael addition of α-substituted isocyanoacetates with maleimides catalyzed by bifunctional tertiary amine thioureas has been developed. Various chiral succinimide derivatives bearing adjacent quaternary and tertiary stereocenters were prepared in excellent yields (up to 98%), diastereoselectivities (up to 99:1), and enantioselectivities (up to 98% ee). The synthetic utility of chiral succinimide derivatives is also demonstrated in the preparation of h5-HT(1d) receptor agonist motifs.


Organic and Biomolecular Chemistry | 2011

Highly enantioselective aldol reaction of acetone with β,γ-unsaturated α-keto esters promoted by simple chiral primary–tertiary diamine catalysts

Lin Peng; Liang-Liang Wang; Jian-Fei Bai; Li-Na Jia; Yunlong Guo; Xi-Ya Luo; Fei-Ying Wang; Xiao-Ying Xu; Li-Xin Wang

A series of primary-tertiary diamine catalysts were successfully applied to promote the enantioselective aldol reaction of acetone with β,γ-unsaturated α-keto esters in excellent yields (up to 99%) and enantioselectivities (up to 96% ee).


RSC Advances | 2013

Highly enantioselective direct vinylogous Michael addition of γ-substituted deconjugated butenolides to maleimides catalyzed by chiral squaramides

Yunlong Guo; Li-Na Jia; Lin Peng; Liang-Wen Qi; Jing Zhou; Fang Tian; Xiao-Ying Xu; Li-Xin Wang

Highly enantioselective direct vinylogous Michael reactions of γ-aryl-substituted deconjugated butenolides with maleimides, catalyzed by only 1 mol% bifunctional squaramides derived from cinchona alkaloids, were achieved with excellent yields (up to 96%) and enantioselectivities (up to 97% ee). This protocol features a very low catalyst loading, mild reaction conditions and provides a potential and effective method for the construction of optically active chiral butenolides with adjacent quaternary and tertiary stereocenters.


Chemical Communications | 2012

Organocatalytic stereocontrolled synthesis of 3,3′-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones

Liang-Liang Wang; Jian-Fei Bai; Lin Peng; Liang-Wen Qi; Li-Na Jia; Yunlong Guo; Xi-Ya Luo; Xiao-Ying Xu; Li-Xin Wang


Organic and Biomolecular Chemistry | 2012

Asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional tertiary amine thiourea: construction of 3-amino-2-oxindoles with quaternary stereocenters

Li-Na Jia; Jun Huang; Lin Peng; Liang-Liang Wang; Jian-Fei Bai; Fang Tian; Guang-Yun He; Xiao-Ying Xu; Li-Xin Wang


Chemical Communications | 2013

An organocatalytic asymmetric sequential allylic alkylation–cyclization of Morita–Baylis–Hillman carbonates and 3-hydroxyoxindoles

Qi-Lin Wang; Lin Peng; Fei-Ying Wang; Mingliang Zhang; Li-Na Jia; Fang Tian; Xiao-Ying Xu; Li-Xin Wang


Tetrahedron Letters | 2011

Highly effective and enantioselective Phospho-Aldol reaction of diphenyl phosphite with N-alkylated isatins catalyzed by quinine

Lin Peng; Liang-Liang Wang; Jian-Fei Bai; Li-Na Jia; Qing-Chuan Yang; Qing-Chun Huang; Xiao-Ying Xu; Li-Xin Wang


Chemical Communications | 2011

A new tetrathiafulvalene–phenoxynaphthacenequinone dyad: switching on the intramolecular electron-transfer with UV light irradiation and metal ion coordination

Li-Na Jia; Guanxin Zhang; Deqing Zhang; Junfeng Xiang; Wei Xu; Daoben Zhu


Journal of Organic Chemistry | 2012

Direct Asymmetric Vinylogous Mannich Reaction of 3,4-Dihalofuran-2(5H)-one with Aldimine Catalyzed by Quinine

Yunlong Guo; Jian-Fei Bai; Lin Peng; Liang-Liang Wang; Li-Na Jia; Xi-Ya Luo; Fang Tian; Xiao-Ying Xu; Li-Xin Wang

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Li-Xin Wang

Chinese Academy of Sciences

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Lin Peng

Chinese Academy of Sciences

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Xiao-Ying Xu

Chinese Academy of Sciences

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Jian-Fei Bai

Chinese Academy of Sciences

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Liang-Liang Wang

Chinese Academy of Sciences

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Fang Tian

Chinese Academy of Sciences

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Xi-Ya Luo

Chinese Academy of Sciences

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Yunlong Guo

Chinese Academy of Sciences

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Guang-Yun He

Chinese Academy of Sciences

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Qi-Lin Wang

Chinese Academy of Sciences

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