Li Qingnuan

Preparation of 99mTc-C60(OH)x and its biodistribution studies

The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C(60) derivative for biodistriburtion studies, the (99m)Tc-labeling of C(60)(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the (99m)Tc-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that (99m)Tc-C(60)(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h.

Radioiodination of C60 Derivative C60(OH)xOy

In this paper water-soluble fullerene derivative C60(OH)xOy was radioiodinated with the iodogen method. The labeling yield was determined by radio-TLC. The effects of pH value, reaction time, temperature and amount of the iodogen on the labeling yield were studied. The labeled product was purified by Sephadex G-25 column chromatography and then the stability of 125I-C60(OH)xOy was examined . The results showed that the radiochemical purity of 125I-C60(OH)xOy solution with benzylalcohol remained 82.7% after 43 hours.

Preparation of (188Re) Re-AEDP and its biodistribution studies

The synthesis of the Re (V) complex and preparation of 188Re-AEDP are described using 188Re which was obtained from the alumina-based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of 188Re-AEDP were 92-93% for carrier-free 188Re and 95-98% for carrier-added 188Re. The stability of 188Re-AEDP at pH approximately 6 was studied and it is found that the carrier has a significant effect on the stability of 188Re-AEDP. The biodistribution of carrier-free and carrier-added 188Re-labelled compounds in rats was also measured. The results show that 188Re (carrier-added)-AEDP is a potential bone palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption.

Uranium extraction from simulated salt lake water by an amidoxime-based UHMWPE fiber

A batch of amidoxime (AO)-based ultra-high molecular weight polyethylene (UHMWPE- g -(PAO-co-PAA)) fiber was prepared by a 7u2005L graft polymerization reaction kettle. The chemical structure and morphology were evaluated by means of Fourier transform infrared spectrometry and scanning electron microscope, respectively. The uranium adsorption behaviors of the UHMWPE- g -(PAO-co-PAA) fiber were studied by batch adsorption in simulated salt lake water. Effect of the total dissolved solids (TDS) and initial concentration of uranium on the adsorption behaviors of the fiber was investigated. It was found that after 28u2005d adsorption in the simulated DagzeCo salt lake water, UHMWPE- g -(PAO-co-PAA) fiber with an AO density of 6.0u2005mmolu2005g−1 exhibited a uranium adsorption capacity of 8.29u2005mgu2005g−1. The adsorption capacity decreased with the increment of TDS. In the simulated salt lake water in which TDS was 10 times as the sea water, the adsorption capacity of uranium was 6.63u2005mgu2005g−1. The adsorption capacity increased with the increment of initial concentration of uranium in solution. The uranium adsorption capacity was 4.54u2005mgu2005g−1 in a solution with initial concentration of 187u2005µgu2005L−1 uranium, while the value increased to 17.48u2005mgu2005g−1 with 1639u2005µgu2005L−1 uranium simulated salt lake water solution. This study should shed light on improvement of uranium extraction from salt lake water and further application in uranium recovery from natural resources.

ThF 4 -LiCl-KCl熔盐体系中F - 浓度对Th(IV)电解提取的影响

通过添加LiF和KF调节ThF 4 -LiCl-KCl熔盐体系中的[F - ]/[Th（IV）]比值，并以[F - ]/[Th（IV）]比值代表熔盐中F - 浓度大小，研究了F - 浓度对Th（IV）电解提取率的影响。研究结果表明，在[F - ]/[Th（IV）]比值为4～12时，Th的提取率呈下降趋势，熔盐中F - 浓度的增加对Th在电极上的析出产生消极影响。用计时电势法研究了不同[F - ]/[Th（IV）]比值熔盐体系中Th（IV）的扩散系数，发现[F - ]/[Th（IV）]比值在4～12时，Th（IV）的扩散系数呈现先减小后增加的趋势，在[F - ]/[Th（IV）]比值为8时出现一个拐点；但由于F - 浓度的增加显著降低了Th（IV）电解过程的电流密度，最终导致相同电解时间内Th的提取率呈下降趋势。

A common spectral characteristic of several benzoyl compounds at about 0.8 THz

We have found that several different chemical compounds with benzoyl group have a similar absorption peak around 0.8 THz. Quantum chemical calculation results suggest the motion at about 0.8 THz is assigned as butterfly mode between the two phenyl rings.