Lia Rieck

Gastroprotective effects of a crude extract of Baccharis illinita DC in rats

Baccharis illinita DC (Compositae) is used in folk medicine to treat gastric disorders. The crude hydroalcoholic extract of leaves and stems tested on mice at doses from 1.0 to 6.0 g/kg, PO, did not produce signs of toxicity. Only the aqueous extract of leaves (0.1 g/kg, PO) increased intestinal motility in mice. The crude hydroalcoholic extract of stems and leaves (HESL) protected rats against lesions induced by ethanol or restraint-in-cold. The crude aqueous extract of roots protected against ulcers induced by ethanol, indomethacin or restraint-in-cold, and the crude aqueous extract of flowers only protected against lesions induced by ethanol. When injected into the duodenal lumen, the aqueous root extract inhibited basal acid secretion in pylorus-ligated rats. The results obtained in the present pharmacological assays indicate that this plant has a protective action against gastric lesions of the mucosa involving the maintenance of protective factors such as mucus, bicarbonate and blood flow, besides the reduction of gastric acid secretion.

Actions of crude hydroalcoholic extract of Pfaffia sp on gastrointestinal tract

As plantas que compoem o genero Pfaffia sao utilizadas na medicina popular para tratar disturbios gastricos. O presente estudo verificou os efeitos de um extrato bruto hidroalcoolico de Pfaffia sp sobre o trato gastrointestinal. Ratos Wistar femeas, foram pre-tratados por via oral (p.o.) com o extrato hidroalcoolico de Pfaffia sp (0,5; 1,0 e 2,0 g/kg) 1 hora antes da inducao de ulceras com estresse por imobilizacao e frio, com etanol 70% ou indometacina. Animais controle receberam agua (C) ou ranitidina (R: 60mg/kg) - p.o. O tratamento com o extrato protegeu a mucosa gastrica contra o aparecimento de ulceras induzidas por estresse e etanol, mas nao foi capaz de proteger a mucosa contra ulceras induzidas por indometacina. Quando injetado pela via intraduodenal (na luz do duodeno - i.d.), o extrato hidroalcoolico de Pfaffia sp inibiu tanto a secrecao acida gastrica basal quanto a estimulada com histamina e betanecol (drogas agonistas), em ratas com ligadura de piloro. Os resultados obtidos neste trabalho indicam que esta planta apresenta acao protetora da mucosa gastrica, envolvendo a reducao da secrecao gastrica.

Vasorelaxant and hypotensive effects of the extract and the isolated flavonoid rutin obtained from Polygala paniculata L.

Objectives  This study aimed to investigate the in‐vitro and in‐vivo cardiovascular effects of the crude hydroalcoholic extract from Polygala paniculata (HEPP) in rats.

Action of crude aqueous extract of leaves of Achillea millefolium L. (Compositae) on gastrointestinal tract

Achillea millefolium L. (Compositeae) is used in folk medicine to treat gastric disturbances. Doses of 125, 1500 and 2000 mg/kg protected rats against ulcers induced by ethanol and restraint-in-cold-stress, but not against indomethacininduced ulcers. Injected into the duodenal lumen the extract inhibited the basal acid secretion. Data from studies indicate that the antiulcer activity of A. millefolium must been related to a inhibition of gastric secretion or to a increase of protective factors in gastric mucosa as mucus, bicarbonate and blood flow. In conclusion, this extract effectively protected the gastric mucosa and inhibited gastric acid secretion. Further studies should also be provided for the stimulation of receptors in the parietal cell to elucidate the route whereby the extract produce this action.