Liana Bastos Freitas-Fernandes
Federal University of Rio de Janeiro
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Publication
Featured researches published by Liana Bastos Freitas-Fernandes.
Journal of Dentistry | 2015
Valeria de Abreu da Silva Bastos; Liana Bastos Freitas-Fernandes; Tatiana Kelly da Silva Fidalgo; Carla Martins; Claudia Trindade Mattos; Ivete Pomarico Ribeiro de Souza; Lucianne Cople Maia
OBJECTIVES A systematic review was performed with the aim of determining whether there is scientific evidence of the transmission of Streptococcus mutans from mother to child. DATA The eligibility criteria, based on the PECO strategy, were the following: observational human studies whose subjects were mother and child pairs (P) contaminated by S. mutans (E); comparison according to the presence or absence of S. mutans (C); and whether there is transmission (O). The qualitative analysis was performed by assessing the risk of bias of the included studies, while quantitative synthesis was performed through comprehensive Meta-Analysis software (p<0.05). SOURCES Two reviewers performed the database search of studies published between January 1950 and May 2014. The strategy included observational studies that assessed the vertical transmission of S. mutans from mothers to children through analyzing genetic strains. STUDY SELECTION It was found 166 non-duplicated studies. However, after reviewing the articles in full and applying the eligibility criteria, 36 papers were selected for qualitative analysis and 19 for quantitative analysis. The cumulative meta-analysis demonstrated vertical transmission of S. mutans from mother to child (p<0.001). CONCLUSIONS The present systematic review and meta-analysis demonstrated evidence of vertical transmission of S. mutans from mother to child because there was an association between S. mutans n mothers and their respective children. CLINICAL SIGNIFICANCE The knowledge of the S. mutans strains is important because the virulence of the microorganisms is varied; also, the virulence affects the dental caries evolution rate, being more or less aggressive.
Journal of Dentistry | 2014
Tatiana Kelly da Silva Fidalgo; Liana Bastos Freitas-Fernandes; Michelle Mikhael Ammari; Claudia Trindade Mattos; Ivete Pomarico Ribeiro de Souza; Lucianne Cople Maia
OBJECTIVES This systematic review and meta-analysis is focused on evaluating the possible association of s-IgA levels and dental caries. DATA The inclusion criteria comprised the clinical investigations with case and control groups, a caries diagnostic method, and evaluation of unspecific s-IgA concentration by using tests for both groups in humans, healthy subjects, and with statistical analyses. Quality assessment and data extraction of the included articles were performed. Meta-analysis of pooled data was performed through RevMan software after a sensitivity analysis. SOURCES An electronic and manual search was performed in PubMed, ISI Web of Science, Scopus, Cochrane Library, and Lilacs, with a supplemental hand search of the references of retrieved articles. STUDY SELECTION From 314 abstracts, 14 fulfilled the inclusion criteria. After reading the full articles, one of them was excluded due to the lack of a control group. Seven studies were included in the meta-analysis, and the heterogeneity among the studies (I(2)) was 41%. The pooled meta-analysis demonstrated higher levels of s-IgA in the caries active group (p<0.00001) than in the control group with a mean difference and confidence interval of 0.27 [0.17-0.38]. CONCLUSIONS Based on these findings, there is evidence that supports the presence of increased s-IgA levels in caries-active subjects. CLINICAL SIGNIFICANCE Dental caries is a multifactorial disease that comprehends intrinsic and extrinsic factors. The risk factors and events related to dental caries are overlooked in the literature. Additionally, it is also important to understand the host response against this disorder. Since the studies are contradictory in this field, we conducted a systematic review followed by meta-analysis to present the immunological host response evidence-based.
Metabolomics | 2015
Tatiana Kelly da Silva Fidalgo; Liana Bastos Freitas-Fernandes; Fabio C. L. Almeida; Ana Paula Valente; Ivete Pomarico Ribeiro de Souza
Abstract Saliva is a biofluid largely used in metabolomics for the assessment of local and systemic diseases. Our group has previously demonstrated the salivary metabolomic signature of children with dental caries (Fidalgo et al. Metabolomics 9(3):657–666, 2013). The aim of the current study was investigation, using NMR spectroscopy, of the changes observed for metabolite markers for caries lesions before and after dental treatment. Saliva from children with and without dental caries before and after treatment was analyzed by NMR. Partial least squared discriminant analysis (PLS-DA) conducted on the spectroscopic data sets showed a clear separation of saliva metabolic profile of children with and without caries, and multilevel PLS-DA demonstrated difference before and after dental treatment. Our results demonstrate that organic acids are associated with disease activity because their reductions were observed after dental treatment. There was a demonstrated reduction here in the levels of acetate, propionate, fatty acid, butyrate and saccharides. We also observed a drop in the level of microorganisms upon dental treatment. The dental treatment therefore modified the properties of the oral cavity, leading to changes in the salivary profiles after treatment.
Journal of Proteome Research | 2016
Livia Roberta Piedade de Oliveira; Carla Martins; Tatiana Kelly da Silva Fidalgo; Liana Bastos Freitas-Fernandes; Rafaela de Oliveira Torres; Aline Laignier Soares; Fabio C. L. Almeida; Ana Paula Valente; Ivete Pomarico Ribeiro de Souza
Metabolomics is an important tool for the evaluation of the human condition, in both health or disease. This study analyzed the salivary components of type I diabetic children (DM1) under six years of age, to assess oral health related to diabetes control, as well as metabolite profiling using NMR. Partial least squared discriminant analysis (PLS-DA) was used to compare healthy (HG) and uncontrolled DM1 subjects that demonstrated a separation between the groups with classificatory performance of ACC = 0.80, R(2) = 0.92, Q(2) = 0.02 and for DM1 children with glycemia >200 mg/dL of ACC = 0.74, R(2) = 0.91, Q(2) = 0.06. The metabolites that mostly contributed to the distinction between the groups in the loading factor were acetate, n-acetyl-sugar, lactate, and sugar. The univariate analysis showed a decreased salivary concentration of succinic acid and increased levels of lactate, acetate, and sucrose in uncontrolled and DM1 children with glycemia >200 mg/dL. The present study demonstrates that the salivary profile of DM1 differs from that of HG children. It appears that diabetes status control has an important effect on the salivary composition.
Special Care in Dentistry | 2018
Rafaela de Oliveira Torres; Andréa Vaz Braga Pintor; Fábio Ribeiro Guedes; Liana Bastos Freitas-Fernandes; Anneliese Lopes Barth; Dafne Dain Gandelman Horovitz; Ivete Pomarico Ribeiro de Souza
We described herein the oral and craniofacial features of a 7-year-old boy, diagnosed in utero with mucopolysaccharidosis II (MPS II), who was treated with hematopoietic stem cell transplantation (HSCT) at 70 days of age. The main oral clinical findings were the following: macroglossia, posterior cross-bite, crowding, pointed cuspid teeth, delayed tooth eruption, retained primary teeth, and enamel hypoplasia. The image examination showed: retention eruption, posterior primary teeth with short roots, absence of some permanent teeth, and stretching of the stylohyoid processes bilaterally. This patient showed the importance of early diagnosis and HSCT therapy in attenuating the clinical and radiographic oral and craniofacial manifestations of the MPS II patient.
Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018
Rafaela de Oliveira Torres; Andréa Vaz Braga Pintor; Fábio Ribeiro Guedes; Lucia Cevidanes; Liana Bastos Freitas-Fernandes; Antônio Carlos de Oliveira Ruellas; Ivete Pomarico Ribeiro de Souza
The objective of this study was to report the clinical evaluation results and 3-dimensional (3-D) dental and craniofacial characteristics observed in 2 male patients with mucopolysaccharidosis type II. The patients were evaluated clinically (soft tissue evaluation, evaluation of occlusion, periodontal and dental examinations) and by using craniofacial computed tomography, with evaluation of 3-D images in ITK-Snap v. 2.2 (Penn Image Computing and Science Laboratory, Philadelphia, PA; http://www.itksnap.org/) and 3-D Slicer (http://www.slicer.org/) software. Mandibular 3-D volumetric label maps were built from computed tomography scans of both patients and compared through superimposition on a healthy patients mandibular images. Clinically, the patients presented the following oral manifestations: macroglossia, total open bite and generalized diastemas, and absence of caries. Patient 1 showed dental calculus and bleeding at the gingival margin. Patient 2 showed bleeding at the gingival margin, a permanent maxillary left central incisor missing as a result of trauma, and impacted permanent mandibular left and right second molars. 3-D images showed wide arches, prominent antegonial notches, a narrow mandibular body in the region of the antegonial notches, bilateral severe condylar hypoplasia, and enlarged coronoid processes. 3-D imaging and superimpositions revealed oral and skeletal displacements, contributing to the identification of changes in the course of mucopolysaccharidosis type II in patients with a late diagnosis.
Metabolomics | 2013
Tatiana Kelly da Silva Fidalgo; Liana Bastos Freitas-Fernandes; Renata Angeli; Adriane M. S. Muniz; Elicardo Gonsalves; Raquel S. Santos; Jurandir Nadal; Fabio C. L. Almeida; Ana Paula Valente; Ivete Pomarico Ribeiro de Souza
Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal) | 2018
Roberta Piedade de Oliveira; Carla Martins; Liana Bastos Freitas-Fernandes; Ivete Pomarico Ribeiro de Souza
Pediatric Dental Journal | 2018
Valéria de Abreu da Silva Bastos; Liana Bastos Freitas-Fernandes; Daniela Novaes Soares; Oswaldo Costa Neto; Aline Corrêa Abrahão; João Alfredo Farinhas; Tatiana Kelly da Silva Fidalgo; Laura Guimarães Primo
Metabolomics | 2017
Priscila A. Almeida; Tatiana Kelly da Silva Fidalgo; Liana Bastos Freitas-Fernandes; Fabio C. L. Almeida; Ivete Pomarico Ribeiro de Souza; Ana Paula Valente