Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by anfa Li.
Bioorganic & Medicinal Chemistry Letters | 2013
Andrew M. K. Pennell; James Aggen; Subhabrata Sen; Wei Chen; Yuan Xu; Edward J. Sullivan; Lianfa Li; Kevin Lloyd Greenman; Trevor Charvat; Derek Hansen; Daniel J. Dairaghi; J. J. Kim Wright; Penglie Zhang
A novel series of CCR1 antagonists based on the 1-(4-phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanone scaffold was identified by screening a compound library utilizing CCR1-expressing human THP-1 cells. SAR studies led to the discovery of the highly potent and selective CCR1 antagonist 14 (CCR1 binding IC(50)=4 nM using [(125)I]-CCL3 as the chemokine ligand). Compound 14 displayed promising pharmacokinetic and toxicological profiles in preclinical species.
Archive | 2014
Penglie Zhang; Andrew M. K. Pennell; John Jessen Wright; Wei Chen; Manmohan Reddy Leleti; Yandong Li; Lianfa Li; Yuan Xu
Archive | 2006
Penglie Zhang; Andrew M. K. Pennell; Wei Chen; Kevin Lloyd Greenman; Edward J. Sullivan; Lianfa Li
Archive | 2006
Penglie Zhang; Andrew M. K. Pennell; John Jessen Wright; Lianfa Li; Edward J. Sullivan; Wei Chen; Kevin Lloyd Greenman
Archive | 2010
Xi Chen; Pingchen Fan; Mark M. Gleason; Juan C. Jaen; Lianfa Li; Jeffrey P. Mcmahon; Jay P. Powers; Yibin Zeng; Penglie Zhang
Archive | 2008
Lianfa Li; Andrew M. K. Pennell; Penglie Zhang
Archive | 2008
Penglie Zhang; Andrew M. K. Pennell; Lianfa Li; Edward J. Sullivan
Archive | 2013
Xi Chen; Junfa Fan; Pingchen Fan; Antoni Krasinski; Lianfa Li; Rebecca M. Lui; Jeffrey P. Mcmahon; Jay P. Powers; Yibin Zeng; Penglie Zhang
Archive | 2013
Xi Chen; Junfa Fan; Pingchen Fan; Antoni Krasinski; Lianfa Li; Rebecca M. Lui; Jeffrey P. Mcmahon; Jay P. Powers; Yibin Zeng; Penglie Zhang
Archive | 2009
Daniel J. Dairaghi; Lianfa Li; Andrew M. K. Pennell; Penglie Zhang
