Liang-Zhong Xu

Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.

A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by (1)H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 mug/mL.

Synthesis and Biological Activities of Novel Triazole Compounds Containing 1,3-Dioxolane Rings

Thirteen new triazoles containing 1,3-dioxolane rings were synthesized and their identities confirmed by means of IR, NMR, MS, elemental analysis and X-ray crystallography. The results of preliminary biological tests show that all of these compounds possess some fungicidal and plant growth regulant activities.

2-Benzoyl-N-phenyl-2-(1,2,4-triazol-1-yl)­thio­acet­amide and 2-(4-methoxy­benzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)­thio­acet­amide

In the two title compounds, C17H14N4OS, (I), and C18H16N4O2S, (II), the dihedral angles between the planes of the triazole and N-phenyl rings and the plane of five of the atoms that link these two rings are 63.5 (8) and 73.2 (6) degrees for (I), and 65.1 (1) and 72.1 (3) degrees for (II), respectively. There are some inter- and intramolecular interactions in the crystal structure.

1,2‐Bis(1,3‐dithio­lan‐2‐ylidene)hydrazine

The title molecule, C6H8N2S4, possesses a crystallographically imposed center of symmetry. The two five-membered rings are in half-chair conformations. The crystal packing is stabilized mainly by van der Waals forces.

4-(4-Chloro­benzyl­ideneamino)-3-(1H-1,2,4-triazol-1-ylmeth­yl)-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C12H10ClN7S, the dihedral angles made by the plane of the thione-substituted triazole ring with the planes of the other triazole ring and the benzene ring are 73.57 (3) and 46.65 (2)degrees, respectively. Inter-and intramolcular hydrogen bonds and pi-pi stacking interactions stabilize the structure.

Ethyl 3-oxo-1,2-benzisothiazoline-2-acetate 1,1-dioxide

In the title compound, C11H11NO5S, the saccharin and ethyl acetate moieties are nearly orthogonal. There are some weak intermolecular hydrogen-bond interactions which stabilize the crystal structure.

3-(2,4-Dichloro­phen­yl)-2-oxo-1-oxaspiro­[4.5]dec-3-en-4-yl 2-methyl­prop-2-enoate

In the title molecule, C19H18Cl2O4, the cyclohexane ring adopts a chair conformation. The furan ring is essentially planar and forms a dihedral angle of 82.1 (1)° with the benzene ring. In the crystal, weak C—H⋯O interactions are present.

(Z)-N-{3-[1-(4-Chloro-phen-yl)eth-yl]thia-zolidin-2-yl-idene}cyanamide.

The title compound, C12H12ClN3S, features a thiazolyl ring having an envelope conformation with the –CH2– group bonded to the S atom forming the flap. The C=N double bond has a Z configuration. The crystal structure shows intermolecular C—H⋯S hydrogen bonds.

2-n-Butyl-1,2-benzisothia­zol-3(2H)-one 1,1-dioxide

The crystal packing of the title compound, C11H13NO3S, exhibits weak intermolecular C—H⋯O hydrogen bonding, which links molecules related by translation along the b axis into chains, and π–π interactions [centroid–centroid distance of 3.778 (2) Å between benzene rings].

1-(2-Chloro-1,3-thia-zol-5-ylmeth-yl)-3,5-dimethyl-2-nitrimino-1,2,3,4,5,6-hexa-hydro-1,3,5-triazine.

In the title compound, C9H13ClN6O2S, all bond lengths and angles are normal. The 1,3,5-triazine ring exhibits a half-chair conformation. In the crystal structure, weak intermolecular C—H⋯N and C—H⋯O hydrogen bonds link the molecules into layers parallel to the bc plane.