Lianzhou Chen
Sun Yat-sen University
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Publication
Featured researches published by Lianzhou Chen.
Hepatology Research | 2009
Jing-Song Chen; Qian Wang; Xin-hui Fu; Xiao-Hui Huang; Xi-Lin Chen; Liang-qi Cao; Lianzhou Chen; Haoxiang Tan; Wen Li; Jiong Bi; Longjuan Zhang
Aim: To investigate the status of Phosphatidylinositol 3‐kinase (PI3K)/PTEN/AKT/mammalian target of rapamycin (mTOR) pathway and its correlation with clinicopathological features and matrix metalloproteinase‐2, ‐9 (MMP‐2, 9) in human hepatocellular carcinoma (HCC).
Hepatology Research | 2009
Xiao-Hui Huang; Qian Wang; Jing-Song Chen; Xin-hui Fu; Xi-Lin Chen; Lianzhou Chen; Wen Li; Jiong Bi; Longjuan Zhang; Qian Fu; Wen-Tao Zeng; Liang-qi Cao; Haoxiang Tan; Qiao Su
Aim: Recent studies have underlined causative links between microRNA (miRNA) deregulation and cancer development. However, the relevance of abnormally expressed miRNA to tumor biology has not been well understood in hepatocellular carcinoma (HCC).
The Journal of Pathology | 2012
Jintang Xia; Zhiqiang Wu; Chunping Yu; Weiling He; Haiqing Zheng; Yulong He; Weihua Jian; Lianzhou Chen; Luanjing Zhang; Wen Li
SPHK1 expression is elevated in gastric cancer and is associated with shorter survival times for patients. However, the molecular mechanism of SPHK1 up‐regulation in gastric cancer remains unclear. In the present study, we report that miR‐124 down‐regulated SPHK1 expression by directly targeting its 3′‐untranslated region (3′‐UTR) and that miR‐124 expression was inversely correlated with SPHK1 expression in gastric cancer samples. Furthermore, we demonstrated that, similar to the effect of silencing SPHK1, up‐regulation of miR‐124 markedly inhibited proliferation and tumourigenicity of gastric cancer cells both in vitro and in vivo. This was found to be mechanistically associated with induction of cyclin‐dependent kinase inhibitors p21
The Journal of Pathology | 2011
Xiao-Hui Huang; Jing-Song Chen; Qian Wang; Xi-Lin Chen; Li Wen; Lianzhou Chen; Jiong Bi; Longjuan Zhang; Qiao Su; Wen-Tao Zeng
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Molecular Biology Reports | 2011
Xin-hui Fu; Qian Wang; Jing-Song Chen; Xiao-Hui Huang; Xi-Lin Chen; Liang-qi Cao; Haoxiang Tan; Wen Li; Longjuan Zhang; Jiong Bi; Qiao Su; Lianzhou Chen
and p27
Pancreas | 2012
Jin-tang Xia; Hua Wang; Li-Jian Liang; Bao-Gang Peng; Zhao-feng Wu; Lianzhou Chen; Ling Xue; Zhi Li; Wen Li
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Journal of Translational Medicine | 2014
Jin-tang Xia; Lianzhou Chen; Wei-hua Jian; Kebing Wang; Yong-zhen Yang; Wei-ling He; Yulong He; De Chen; Wen Li
, enhancement of the transcriptional activity of FOXO1 and suppression of AKT activity. Moreover, we showed that the re‐introduction of SPHK1 (without the 3′‐UTR), but not with the 3′‐UTR, could abrogate the miR‐124‐mediated induction of p21
Hepatology Research | 2014
Xue-wei Yang; Longjuan Zhang; Xiao-Hui Huang; Lianzhou Chen; Qiao Su; Wen-Tao Zeng; Wen Li; Qian Wang
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Oncology Reports | 2014
Dong Wang; Liang Luo; Wei Chen; Lianzhou Chen; Wen-Tao Zeng; Wen Li; Xiao-Hui Huang
and p27
Biochemical and Biophysical Research Communications | 2015
Ning Ma; Fan Chen; Shun-Li Shen; Wei Chen; Lianzhou Chen; Qiao Su; Longjuan Zhang; Jiong Bi; Wen-Tao Zeng; Wen Li; Xiao-Hui Huang; Qian Wang
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