Lianzhou Chen

Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP‐9

Aim:  To investigate the status of Phosphatidylinositol 3‐kinase (PI3K)/PTEN/AKT/mammalian target of rapamycin (mTOR) pathway and its correlation with clinicopathological features and matrix metalloproteinase‐2, ‐9 (MMP‐2, 9) in human hepatocellular carcinoma (HCC).

Bead‐based microarray analysis of microRNA expression in hepatocellular carcinoma: miR‐338 is downregulated

Aim:  Recent studies have underlined causative links between microRNA (miRNA) deregulation and cancer development. However, the relevance of abnormally expressed miRNA to tumor biology has not been well understood in hepatocellular carcinoma (HCC).

miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1†

SPHK1 expression is elevated in gastric cancer and is associated with shorter survival times for patients. However, the molecular mechanism of SPHK1 up‐regulation in gastric cancer remains unclear. In the present study, we report that miR‐124 down‐regulated SPHK1 expression by directly targeting its 3′‐untranslated region (3′‐UTR) and that miR‐124 expression was inversely correlated with SPHK1 expression in gastric cancer samples. Furthermore, we demonstrated that, similar to the effect of silencing SPHK1, up‐regulation of miR‐124 markedly inhibited proliferation and tumourigenicity of gastric cancer cells both in vitro and in vivo. This was found to be mechanistically associated with induction of cyclin‐dependent kinase inhibitors p21

miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened†

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Clinical significance of miR-221 and its inverse correlation with p27Kip1 in hepatocellular carcinoma

and p27

Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma.

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MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-κB signaling

, enhancement of the transcriptional activity of FOXO1 and suppression of AKT activity. Moreover, we showed that the re‐introduction of SPHK1 (without the 3′‐UTR), but not with the 3′‐UTR, could abrogate the miR‐124‐mediated induction of p21

miR‐145 suppresses cell invasion in hepatocellular carcinoma cells: miR‐145 targets ADAM17

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Significance of the vascular endothelial growth factor and the macrophage migration inhibitory factor in the progression of hepatocellular carcinoma

and p27

MicroRNA-129-5p inhibits hepatocellular carcinoma cell metastasis and invasion via targeting ETS1

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