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Dive into the research topics where Libertario Demi is active.

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Featured researches published by Libertario Demi.


IEEE Transactions on Aerospace and Electronic Systems | 2011

Target Recognition by Means of Polarimetric ISAR Images

Marco Martorella; Elisa Giusti; Libertario Demi; Zheng-Shu Zhou; Andrea Cacciamano; Fabrizio Berizzi; B. Bates

Automatic target recognition (ATR) is generally the reason why inverse synthetic aperture radar (ISAR) imaging systems are employed. Moreover, the use of fully polarimetric radar systems in radar imaging applications such as SAR and ISAR has enhanced both image quality and classification capabilities. The authors propose a novel technique for ATR using polarimetric ISAR (Pol-ISAR) images. The proposed method is based on a model matching approach. Results are obtained that show the effectiveness of such a technique.


Journal of the Acoustical Society of America | 2011

Comparison of fundamental, second harmonic, and superharmonic imaging: a simulation study

P.L.M.J. van Neer; Mikhail G. Danilouchkine; Verweij; Libertario Demi; M.M. Voormolen; A.F.W. van der Steen; N. de Jong

In medical ultrasound, fundamental imaging (FI) uses the reflected echoes from the same spectral band as that of the emitted pulse. The transmission frequency determines the trade-off between penetration depth and spatial resolution. Tissue harmonic imaging (THI) employs the second harmonic of the emitted frequency band to construct images. Recently, superharmonic imaging (SHI) has been introduced, which uses the third to the fifth (super) harmonics. The harmonic level is determined by two competing phenomena: nonlinear propagation and frequency dependent attenuation. Thus, the transmission frequency yielding the optimal trade-off between the spatial resolution and the penetration depth differs for THI and SHI. This paper quantitatively compares the concepts of fundamental, second harmonic, and superharmonic echocardiography at their optimal transmission frequencies. Forward propagation is modeled using a 3D-KZK implementation and the iterative nonlinear contrast source (INCS) method. Backpropagation is assumed to be linear. Results show that the fundamental lateral beamwidth is the narrowest at focus, while the superharmonic one is narrower outside the focus. The lateral superharmonic roll-off exceeds the fundamental and second harmonic roll-off. Also, the axial resolution of SHI exceeds that of FI and THI. The far-field pulse-echo superharmonic pressure is lower than that of the fundamental and second harmonic. SHI appears suited for echocardiography and is expected to improve its image quality at the cost of a slight reduction in depth-of-field.


Journal of the Acoustical Society of America | 2011

A contrast source method for nonlinear acoustic wave fields in media with spatially inhomogeneous attenuation

Libertario Demi; K.W.A. van Dongen; Martin D. Verweij

Experimental data reveals that attenuation is an important phenomenon in medical ultrasound. Attenuation is particularly important for medical applications based on nonlinear acoustics, since higher harmonics experience higher attenuation than the fundamental. Here, a method is presented to accurately solve the wave equation for nonlinear acoustic media with spatially inhomogeneous attenuation. Losses are modeled by a spatially dependent compliance relaxation function, which is included in the Westervelt equation. Introduction of absorption in the form of a causal relaxation function automatically results in the appearance of dispersion. The appearance of inhomogeneities implies the presence of a spatially inhomogeneous contrast source in the presented full-wave method leading to inclusion of forward and backward scattering. The contrast source problem is solved iteratively using a Neumann scheme, similar to the iterative nonlinear contrast source (INCS) method. The presented method is directionally independent and capable of dealing with weakly to moderately nonlinear, large scale, three-dimensional wave fields occurring in diagnostic ultrasound. Convergence of the method has been investigated and results for homogeneous, lossy, linear media show full agreement with the exact results. Moreover, the performance of the method is demonstrated through simulations involving steered and unsteered beams in nonlinear media with spatially homogeneous and inhomogeneous attenuation.


IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control | 2012

Parallel transmit beamforming using orthogonal frequency division multiplexing applied to harmonic Imaging-A feasibility study

Libertario Demi; Martin D. Verweij; K.W.A. van Dongen

Real-time 2-D or 3-D ultrasound imaging systems are currently used for medical diagnosis. To achieve the required data acquisition rate, these systems rely on parallel beamforming, i.e., a single wide-angled beam is used for transmission and several narrow parallel beams are used for reception. When applied to harmonic imaging, the demand for high-amplitude pressure wave fields, necessary to generate the harmonic components, conflicts with the use of a wide-angled beam in transmission because this results in a large spatial decay of the acoustic pressure. To enhance the amplitude of the harmonics, it is preferable to do the reverse: transmit several narrow parallel beams and use a wide-angled beam in reception. Here, this concept is investigated to determine whether it can be used for harmonic imaging. The method proposed in this paper relies on orthogonal frequency division multiplexing (OFDM), which is used to create distinctive parallel beams in transmission. To test the proposed method, a numerical study has been performed, in which the transmit, receive, and combined beam profiles generated by a linear array have been simulated for the second-harmonic component. Compared with standard parallel beamforming, application of the proposed technique results in a gain of 12 dB for the main beam and in a reduction of the side lobes. Experimental verification in water has also been performed. Measurements obtained with a single-element emitting transducer and a hydrophone receiver confirm the possibility of exciting a practical ultrasound transducer with multiple Gaussian modulated pulses, each having a different center frequency, and the capability to generate distinguishable second-harmonic components.


IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control | 2015

4-D spatiotemporal analysis of ultrasound contrast agent dispersion for prostate cancer localization: a feasibility study

Sg Stefan Schalk; Libertario Demi; Martijn Smeenge; David Martin Mills; Kirk Wallace; Jean de la Rosette; Hessel Wijkstra; M Massimo Mischi

Currently, nonradical treatment for prostate cancer is hampered by the lack of reliable diagnostics. Contrastultrasound dispersion imaging (CUDI) has recently shown great potential as a prostate cancer imaging technique. CUDI estimates the local dispersion of intravenously injected contrast agents, imaged by transrectal dynamic contrast-enhanced ultrasound (DCE-US), to detect angiogenic processes related to tumor growth. The best CUDI results have so far been obtained by similarity analysis of the contrast kinetics in neighboring pixels. To date, CUDI has been investigated in 2-D only. In this paper, an implementation of 3-D CUDI based on spatiotemporal similarity analysis of 4-D DCE-US is described. Different from 2-D methods, 3-D CUDI permits analysis of the entire prostate using a single injection of contrast agent. To perform 3-D CUDI, a new strategy was designed to estimate the similarity in the contrast kinetics at each voxel, and data processing steps were adjusted to the characteristics of 4-D DCE-US images. The technical feasibility of 4-D DCE-US in 3-D CUDI was assessed and confirmed. Additionally, in a preliminary validation in two patients, dispersion maps by 3-D CUDI were quantitatively compared with those by 2-D CUDI and with 12-core systematic biopsies with promising results.


IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control | 2013

Implementation of parallel transmit beamforming using orthogonal frequency division multiplexing-achievable resolution and interbeam interference

Libertario Demi; Jacopo Viti; Lieneke Kusters; Francesco Guidi; Piero Tortoli; M Massimo Mischi

The speed of sound in the human body limits the achievable data acquisition rate of pulsed ultrasound scanners. To overcome this limitation, parallel beamforming techniques are used in ultrasound 2-D and 3-D imaging systems. Different parallel beamforming approaches have been proposed. They may be grouped into two major categories: parallel beamforming in reception and parallel beamforming in transmission. The first category is not optimal for harmonic imaging; the second category may be more easily applied to harmonic imaging. However, inter-beam interference represents an issue. To overcome these shortcomings and exploit the benefit of combining harmonic imaging and high data acquisition rate, a new approach has been recently presented which relies on orthogonal frequency division multiplexing (OFDM) to perform parallel beamforming in transmission. In this paper, parallel transmit beamforming using OFDM is implemented for the first time on an ultrasound scanner. An advanced open platform for ultrasound research is used to investigate the axial resolution and interbeam interference achievable with parallel transmit beamforming using OFDM. Both fundamental and second-harmonic imaging modalities have been considered. Results show that, for fundamental imaging, axial resolution in the order of 2 mm can be achieved in combination with interbeam interference in the order of -30 dB. For second-harmonic imaging, axial resolution in the order of 1 mm can be achieved in combination with interbeam interference in the order of -35 dB.


IEEE Transactions on Biomedical Engineering | 2015

Compressed sensing for ultrasound computed tomography.

Rjg Ruud van Sloun; Ashish Pandharipande; M Massimo Mischi; Libertario Demi

Ultrasound computed tomography (UCT) allows the reconstruction of quantitative tissue characteristics, such as speed of sound, mass density, and attenuation. Lowering its acquisition time would be beneficial; however, this is fundamentally limited by the physical time of flight and the number of transmission events. In this letter, we propose a compressed sensing solution for UCT. The adopted measurement scheme is based on compressed acquisitions, with concurrent randomised transmissions in a circular array configuration. Reconstruction of the image is then obtained by combining the born iterative method and total variation minimization, thereby exploiting variation sparsity in the image domain. Evaluation using simulated UCT scattering measurements shows that the proposed transmission scheme performs better than uniform undersampling, and is able to reduce acquisition time by almost one order of magnitude, while maintaining high spatial resolution.


Journal of Ultrasound in Medicine | 2016

On the Physical Basis of Pulmonary Sonographic Interstitial Syndrome.

Gino Soldati; Marcello Demi; Riccardo Inchingolo; Andrea Smargiassi; Libertario Demi

ung sonography is widely accepted and used in emergency medicine and critical care.1–5 Moreover, many pulmonologists are interested in chest sonography for the study of pleural diseases and are increasingly discovering a role for sonography in parenchymal lung diseases.6–9 For those physicians who are devoted to chest sonography, a clear dichotomy between usual sonography and aerated tissue sonography is obvious. Pleural sonography is effective under most circumstances, whereas lung sonography is effective only when certain physical properties of the lung (eg, the bubble system) are lost. In other words, the lung is sonographically explorable only when it is physically comparable with soft tissue. In particular, when using lung sonography, a lung that contains dispersed air and has a density that is not comparable with the density of water does not show anatomic images but rather artifactual images.10 Therefore, lung artifacts are quite consistent with the physical properties of a lung that is not fully consolidated rather than with an anatomic image.11 The physical properties of the subpleural nonconsolidated lung are the hallmarks of many pulmonary diseases, which can be roughly grouped into “interstitial diseases.” If an ultrasound imaging system is used, all of these pulmonary diseases are classified by the generic term “sonographic interstitial syndrome” (B-lines with variable arrangements along the pleural line).5 According to this view, it is not surprising that since 1997,12 vertical lung artifacts, commonly named B-lines, have been associated with pathologic conditions ranging from pulmonary edema to fibrosis, which are characterized by a change in the subpleural physical features in terms of full and empty spaces.11 Gino Soldati, MD Emergency Medicine Unit Valle del Serchio General Hospital Lucca, Italy


Reference Module in Biomedical Sciences#R##N#Comprehensive Biomedical Physics | 2014

Simulation of ultrasound fields

Verweij; Bradley E. Treeby; van Kwa Dongen; Libertario Demi

This chapter addresses the simulation of ultrasound fields that form the basis of various medical diagnostic and therapeutic applications. It aims to cover the entire spectrum of existing simulation methods by considering semianalytical methods as well as numerical methods and by dealing with both linear and nonlinear ultrasound propagation. The finite-difference, pseudospectral, and integral equation methods are treated in detail, and a comparison between the latter two methods is presented. Several simulation packages are discussed.


internaltional ultrasonics symposium | 2010

Modeling nonlinear acoustic wave fields in media with inhomogeneity in the attenuation and in the nonlinearity

Libertario Demi; Martin D. Verweij; N. de Jong; K.W.A. van Dongen

Biomedical tissues usually show inhomogeneity in their acoustic medium parameters. These inhomogeneities cause refraction and scattering of diagnostic and therapeutic ultrasound waves. A method that is able to model the effects of inhomogeneity in the attenuation and in the nonlinearity is essential for the design of transducers for new ultrasound modalities and the development of novel ultrasound applications. The Iterative Nonlinear Contrast Source (INCS) method has originally been designed for the accurate modeling of nonlinear acoustic wave fields in homogeneous media. It considers the nonlinear term from the Westervelt equation as a distributed contrast source, and the corresponding integral equation is solved using an iterative Neumann scheme. This paper presents an extension of the INCS method that can handle inhomogeneity in the attenuation and in the coefficient of nonlinearity. Results are presented for the one-dimensional case. These show that in this case the presented method correctly predicts the effects related to nonlinear propagation and scattering by inhomogeneities in the attenuation and the coefficient of non-linearity.

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M Massimo Mischi

Eindhoven University of Technology

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Hessel Wijkstra

Eindhoven University of Technology

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Martin D. Verweij

Delft University of Technology

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Ruud J. G. van Sloun

Eindhoven University of Technology

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K.W.A. van Dongen

Delft University of Technology

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Koen W. A. van Dongen

Delft University of Technology

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Sg Stefan Schalk

Eindhoven University of Technology

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Rjg Ruud van Sloun

Eindhoven University of Technology

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