Lieve Filbrich
Ghent University
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Publication
Featured researches published by Lieve Filbrich.
Psychophysiology | 2014
Lieve Filbrich; Louis Favril; André Mouraux; Chiara F. Sambo; Valéry Legrain
The study tested whether nociceptive stimuli applied to a body limb can orient spatial attention in external space toward visual stimuli delivered close to that limb. Nociceptive stimuli were applied to either the left or the right hand. Task-relevant visual stimuli were delivered at the location adjacent to the stimulated hand (70% valid trials) or adjacent to the other hand (30% invalid trials). Visual stimuli were discriminated with shorter reaction times and elicited ERPs of greater magnitude in the valid as compared to the invalid trials. This enhancement affected the N1 component, suggesting that the location of the nociceptive cue modifies visual processing through a modulation of neural activity in the visual cortex. We hypothesize the existence of a common frame of reference able to coordinate the mapping of the space of the body and the mapping of the external space.
PLOS ONE | 2017
Lieve Filbrich; Andrea Alamia; Séverine Blandiaux; Soline Burns; Valéry Legrain
Coordinating spatial perception between body space and its external surrounding space is essential to adapt behaviors to objects, especially when they are noxious. Such coherent multisensory representation of the body extended into external space is conceptualized by the notion of peripersonal reference frame, mapping the portion of space in which somatic and extra-somatic inputs interact closely. Studies on crossmodal interactions between nociception and vision have been scarce. Here we investigated how the perception of visual stimuli, especially those surrounding the body, can be impacted by a nociceptive and potentially harmful stimulus inflicted on a particular body part. In two temporal order judgment tasks, participants judged which of two lateralized visual stimuli, presented either near or far from the body, had been presented first. Visual stimuli were preceded by nociceptive stimuli, either applied unilaterally (on one single hand) or bilaterally (on both hands simultaneously). In Experiment 1 participants’ hands were always placed next to the visual stimuli presented near the trunk, while in Experiment 2 they could also be placed next to the visual stimuli presented far from the trunk. In Experiment 1, the presence of unilateral nociceptive stimuli prioritized the perception of visual stimuli presented in the same side of space as the stimulated hand, with a significantly larger effect when visual stimuli were presented near the body than when presented farther away. Experiment 2 showed that these visuospatial biases were related to the spatial congruency between the hand on which nociceptive stimuli were applied and the visual stimuli, independently of the relative distance of both the stimulated hand and the visual stimuli from the trunk. Indeed, nociceptive stimuli mostly impacted the perception of the closest visual stimuli. It is hypothesized that these crossmodal interactions may rely on representations of the space directly surrounding specific body parts.
Pain | 2017
Diana Torta; Emanuel N. van den Broeke; Lieve Filbrich; Benvenuto Jacob; Julien Lambert; André Mouraux
Abstract Sensitization is a form of implicit learning produced by the exposure to a harmful stimulus. In humans and other mammals, sensitization after skin injury increases the responsiveness of peripheral nociceptors and enhances the synaptic transmission of nociceptive input in the central nervous system. Here, we show that sensitization-related changes in the central nervous system are not restricted to nociceptive pathways and, instead, also affect other sensory modalities, especially if that modality conveys information relevant for the sensitized body part. Specifically, we show that after sensitizing the forearm using high-frequency electrical stimulation (HFS) of the skin, visual stimuli projected onto the sensitized forearm elicit significantly enhanced brain responses. Whereas mechanical hyperalgesia was present both 20 and 45 minutes after HFS, the enhanced responsiveness to visual stimuli was present only 20 minutes after HFS. Taken together, our results indicate that sensitization involves both nociceptive-specific and multimodal mechanisms, having distinct time courses.
Pain Mechanisms and Therapeutics Conference June 2018 | 2018
Lieve Filbrich; Valéry Legrain; André Mouraux
Neuronus 2018 IBRO Neuroscience Forum | 2018
Louise Manfron; Lieve Filbrich; Séverine Blandiaux; Farnè Alessandro; Roxane De Keyser; Valéry Legrain
Pain Research Meeting 2017 | 2017
Lieve Filbrich; Charlotte Verfaille; Anne Berquin; Olivier Barbier; Xavier Libouton; Virginie Fraselle; Dominique Mouraux; Valéry Legrain
Laser Talks in Brussels (Laser talks in Europe 8th edition) | 2017
Valéry Legrain; Camille Vanderclausen; Marion Bourgois; Lieve Filbrich
18th International Multisensory Research Forum (IMRF 2017) | 2017
Camille Vanderclausen; Andrea Alamia; Lieve Filbrich; Anne De Volder; Valéry Legrain
18th International Multisensory Research Forum | 2017
Lieve Filbrich; Andrea Alamia; Séverine Blandiaux; Soline Burns; Valéry Legrain
Poster presentation at the 16th IASP World Congress on Pain | 2016
Diana Torta; Lieve Filbrich; Emanuel N. van den Broeke; Valéry Legrain