Lilach Shalev

Opposite biases in salience-based selection for the left and right posterior parietal cortex.

Visual selection is determined in part by the saliency of stimuli. We assessed the brain mechanisms determining attentional responses to saliency. Repetitive transcranial magnetic stimulation (rTMS) was applied to the left and right posterior parietal cortices (PPC) immediately before participants were asked to identify a compound letter. rTMS to the right PPC disrupted the guidance of attention toward salient stimuli, whereas rTMS to the left PPC affected the ability to bias selection away from salient stimuli. We conclude that right and left PPC have opposite roles in biasing selection to and from salient stimuli in the environment.

The Diversity of Attention Deficits in ADHD The Prevalence of Four Cognitive Factors in ADHD Versus Controls

The performance of participants with attention-deficit/hyperactivity disorder (ADHD) relative to control participants was measured on four tasks uniquely assessing the functions of selective attention, executive attention, sustained attention, and orienting of attention. The results showed that deficits in sustained attention were the most pronounced, characterizing most participants with ADHD and deficits in each of the other three functions characterized more than half of these participants. Different participants with ADHD revealed different clusters of attentional deficits. These results call for a revision of leading theories of ADHD that identify the core of the pathology as a sole deficit in executive functions.

Inattention Magnifies Perceived Length: The Attentional Receptive Field Hypothesis

Five experiments demonstrated that a briefly presented vertical line is judged as longer when it is unattended relative to when it is attended. This effect was obtained in estimating the length of 1 of 5 possible lines (Experiment 1) and in matching the length of a test line to a criterion line (Experiments 3 and 4). The directional effect of attention was eliminated when participants estimated the length difference between 2 simultaneously presented lines (Experiment 2). An additional matching experiment (Experiment 5) demonstrated similar lengthening effects for unattended lines and for unattended distances separated by vertically displaced dots. It is proposed that the metric for unattended stimuli is composed of large attentional receptive fields and that the final output is mediated by rounding up processes, so that the unattended line is systematically perceived as longer than the attended one.

Stroop and Garner effects in and out of Posner's beam: Reconciling two conceptions of selective attention.

Space- or object-based models, on the one hand, and structural-informational models, on the other hand, reflect conceptually distinct approaches to visual selective attention. In 3 studies, the authors contrasted these approaches by jointly applying prototypical routines prescribed in each approach. Following a space-based paradigm developed by M. I. Posner, participants were cued to attend to a certain spatial location, and performance at expected and unexpected locations was compared. Following a structural paradigm developed by W. R. Garner, the targets were color words printed in various colors, and the participants responded to either the color or the word component of the stimulus. Performance was poorer at unexpected than at expected locations. However, comparable amounts of Stroop and Garner interference affected performance at both expected and unexpected locations. It is suggested that the processes that govern (a) input selection from the visual field and (b) dimensional selection from the stimulus reflect fundamentally different systems of attention.

Ignoring the elephant in the room: a neural circuit to downregulate salience.

How do we ignore stimuli that are salient but irrelevant when our task is to select a lower salient stimulus? Since bottom–up processes favor high saliency, detection of a low-salient target in the presence of highly salient distractors requires top–down attentional guidance. Previous studies have demonstrated that top–down attention can modulate perceptual processing and also that the control of attention is driven by frontoparietal regions. However, to date, there is no direct evidence on the cause and effect relationship between control regions and perceptual processing. Here, we report the first evidence demonstrating a neural circuit for the downregulation of salient distractors when a low-salient target is selected, combining brain imaging using functional magnetic resonance imaging with brain stimulation by transcranial magnetic stimulation. Using these combined techniques, we were able to identify a cause and effect relationship in the suppression of saliency, based on an interaction between the left intraparietal sulcus (IPS) and a region implicated in visual processing in our task (the left occipital pole). In particular, low-salient stimuli were selected by the left IPS suppressing early visual areas that would otherwise respond to a high-saliency distractor in the task. Apart from providing a first documentation of the neural circuit supporting selection by saliency, these data can be critical for understanding the underlying causes of problems in ignoring irrelevant salience that are found in both acquired and neurodevelopmental disorders (e.g., attention deficit/hyperactivity disorder or autism).

The Role of Sustained Attention and Display Medium in Reading Comprehension among Adolescents with ADHD and without It.

Difficulties in reading comprehension are common in children and adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). The current study aimed at investigating the relation between sustained attention and reading comprehension among adolescents with and without ADHD. Another goal was to examine the impact of two manipulations of the text on the efficiency of reading comprehension: Spacing (standard- vs. double-spacing) and Type of presentation (computer screen vs. hard copy). Reading comprehension of two groups of adolescents (participants with ADHD and normal controls) was assessed and compared in four different conditions (standard printed, spaced printed, standard on computer screen, spaced on computer screen). In addition, participants completed a visual sustained attention task. Significant differences in reading comprehension and in sustained attention were obtained between the two groups. Also, a significant correlation was obtained between sustained attention and reading comprehension. Moreover, a significant interaction was revealed between presentation-type, spacing and level of sustained attention on reading comprehension. Implications for reading intervention and the importance of early assessment of attention functioning are discussed.

Conjunctive Continuous Performance Task (CCPT)—A pure measure of sustained attention ☆

Among the large variety of attentional tasks that have been used to study sustained attention, the Continuous Performance Task (CPT) is perhaps the most widely used. Despite substantial differences in task characteristics and demands, all CPT paradigms have been referred to as measures of sustained attention. In the present study we introduce a new variant of CPT, which minimizes perceptual and memory components while maximizing the sustained attention components of the task. In addition, we tested the contention that the ability to sustain attention should not be overly dependent on the specific stimuli and task-modality. To this end, we used a new visual Conjunctive CPT (CCPT) developed by Tsal, Shalev, & Mevorach (2005) and its auditory analogue. Using a Multi-Trait-Multi-Method (MTMM) analysis investigating reliability coefficients, convergent validity coefficients and divergent (discriminant) validity coefficients, we established that the new CCPT is a valid measure of sustained attention. In particular, high correlations were obtained between mean RT and SD-RT within each sensory modality. High correlations were also found between performance across sensory modalities (mean convergent validity: .71). Finally, low correlations (mean correlation of .18) were found between performance in the CCPT tasks and performance in two additional visuospatial attention tasks, which do not rely on sustained attention. These findings suggest that independent of sensory modality, the two CCPT tasks used here tap the same stable construct, namely, sustained attention. We conclude that when a measure of sustained attention is required, researchers should be aware of the caveats of standard CPTs and should be careful in selecting a proper task. Moreover, clinicians should appreciate that some CPT measures may reflect a combination of different cognitive operations rather than pure sustained attention.

The left intraparietal sulcus modulates the selection of low salient stimuli

Neuropsychological and functional imaging studies have suggested a general right hemisphere advantage for processing global visual information and a left hemisphere advantage for processing local information. In contrast, a recent transcranial magnetic stimulation study [Mevorach, C., Humphreys, G. W., & Shalev, L. Opposite biases in salience-based selection for the left and right posterior parietal cortex. Nature Neuroscience, 9, 740–742, 2006b] demonstrated that functional lateralization of selection in the parietal cortices on the basis of the relative salience of stimuli might provide an alternative explanation for previous results. In the present study, we applied a whole-brain analysis of the functional magnetic resonance signal when participants responded to either the local or the global levels of hierarchical figures. The task (respond to local or global) was crossed with the saliency of the target level (local salient, global salient) to provide, for the first time, a direct contrast between brain activation related to the stimulus level and that related to relative saliency. We found evidence for lateralization of salience-based selection but not for selection based on the level of processing. Activation along the left intraparietal sulcus (IPS) was found when a low saliency stimulus had to be selected irrespective of its level. A control task showed that this was not simply an effect of task difficulty. The data suggest a specific role for regions along the left IPS in salience-based selection, supporting the argument that previous reports of lateralized responses to local and global stimuli were contaminated by effects of saliency.

Effects of saliency, not global dominance, in patients with left parietal damage

Neuropsychological and functional imaging studies have shown a general right hemisphere advantage for processing global visual information and a left hemisphere advantage for processing local information. There is also evidence for the left parietal lobe being important for switching attention between local and global levels. Here we examined whether the left parietal lobe is associated with another aspect of attentional control over hierarchical visual processing; namely, ignoring the irrelevant aspect of the stimulus when it is more salient than the target attribute. In experiment 1 a group of left parietal patients were abnormally affected by a salient local stimulus that significantly interfered with their ability to identify global shapes. This effect was reversed in experiment 2 when small sized compound letters were used (where the global shape was more salient than the local letters). The patients then had difficulty ignoring the global shape. Experiments 3 and 4 demonstrated that the failure to accurately identify global form in experiment 1 could not be attributed to a difficulty in spreading attention across a large area. Finally, in experiment 4 the effect of a salient irrelevant stimulus was significantly attenuated when the irrelevant level did not map onto a response. The data indicate that damage to the left parietal lobe disrupts the ability to select attributes of stimuli that have low salience when other attributes have high salience for the task.

Attention reduces perceived brightness contrast.

The effects of attention on brightness perception was investigated in four experiments. In the first three, subjects estimated the brightness of a briefly presented small grey square by selecting a number that corresponded to one of four possible squares varying on a lightness-darkness dimension. In the last experiment, subjects matched the brightness of two peripheral squares, one attended and one unattended. When the stimulus appeared on a white background (Experiments 1, 2, and 4a) it was judged as brighter when attention was directed to its location than when attention was diverted to another location. When the stimulus appeared on a dark background (Experiments 3 and 4b), the opposite pattern of results was obtained: the attended stimulus was judged as darker than the unattended one. These results show that attention reduces the perceived contrast between the stimulus and its background, suggesting that attention enables subjects to provide a more veridical judgement of stimulus brightness by limiting processing resources to the square itself, at the expense of the surrounding background. As attention produced a directional brightness effect rather than just an improvement in report accuracy, the results can be attributed to early perceptual processing effects, hence providing support for early selection views of attention.