Lilian Soares da Costa

P-665: Effect of hormone replacement therapy and raloxifene on exercise testing and dispersion of ventricular repolarization in treated hypertensive postmenopausal women

EFFECT OF HORMONE REPLACEMENT THERAPY AND RALOXIFENE ON EXERCISE TESTING AND DISPERSION OF VENTRICULAR REPOLARIZATION IN TREATED HYPERTENSIVE POSTMENOPAUSAL WOMEN Lı́lian S Costa, Monica A Oliveira, Valeria M Rubim, João Carlos Tress, Jose M Aldrighi, Mauricio Wajngarten, Cantidio Drumond Neto, Otavio E Gebara. Cardiology, Rio de Janeiro Santa Casa de Misericordia Hospital, Rio de Janeiro, RJ, Brazil; Cardiogeriatry, INCOR Sao Paulo Heart Institute, Sao Paulo, SP, Brazil.

P-266: The effect of hormone replacement therapy on vascular compliance in postmenopausal women

Abstract P-266 Key Words: Postmenopausal, Pulse Wave Velocity, Ambulatory Blood Pressure Monitoring

The effect of accupril on circadian blood pressure patterns in hypertensive subjects with left ventricle hypertrophy

Abstract P-190 Key Words: Ambulatory Blood Pressure Monitoring, Left Ventricular Hypertrophy, Pharmacology Therapy

Verapamil COER-24 180/240mg na hipertensão arterial leve a moderada em dose única diária avaliado pela monitorização ambulatorial da pressão arterial

OBJETIVO: Avaliar a eficacia terapeutica do verapamil COER-24 180/240 mg, em dose unica, ao deitar, como monoterapia para a hipertensao arterial leve a moderada. METODOS: Estudo multicentrico, aberto, nao comparativo com 81 pacientes de ambos os sexos, com idade >20 anos e hipertensao arterial essencial leve e moderada. Medimos a pressao arterial no consultorio e com a monitorizacao ambulatorial (MAPA) durante 24h antes e ao final de 8 semanas do uso da medicacao. RESULTADOS: Verificou-se diminuicao (p<0,0001) das pressoes sistolicas e diastolicas medidas no consultorio as semanas 3 e 8. A MAPA demonstrou que tanto a pressao sistolica, diastolica, media e frequencia cardiaca, quando as cargas pressoricas medias de 24h apresentaram reducoes apos 8 semanas de tratamento, alem da reducao do duplo-produto, especialmente pela manha. A tolerabilidade foi boa, 68% dos pacientes nao apresentaram eventos adversos. CONCLUSAO: A monoterapia com o verapamil COER-24 180/240mg em dose unica e eficaz para o controle da pressao arterial em hipertensos leves e moderados, com reducao tanto na pressao casual quanto na MAPA/24h, alem de apresentar boa tolerabilidade.

Avaliaçäo do perfil arritmogênico ventricular de pacientes com miocardiopatia dilatada e fraçäo de ejeçäo diminuída

PURPOSE: To evaluate the arrhythmogenic profile of patients with dilated cardiomyopathy of low ejection fraction and its prognostic significance. METHODS: Data from 40 patients (30 males; mean age: 52±13 years) were analysed including ventricular arrhythmias (24h - Holter monitoring), autonomic balance from heart rate variability in time domain (rMSSD and pNN50 indexes), ventricular late potentials (signal averaged electrocardiogram (ECG)) and dispersion of ventricular repolarization measured from 12-lead ECG. RESULTS: There was a high prevalence of ventricular arrhythmias with at least one episode of nonsustained ventricular tachycardia (VT) in 60% of the patients. Depressed vagal activity was observed in more than half of the patients. In only 30% of the patients the signal-averaged ECG was positive. The dispersion of ventricular repolarization ranged from 20 to 100ms. The presence of >30 ventricular premature beats or nonsustained VT on Holter monitoring was the most significant predictor of cardiac death and sudden cardiac death with a relative risk of 1.9 and 3.2, respectively (p= 0.01 and 0.000). CONCLUSION: In this study population it was noted that patients with dilated cardiomyopathy and low ejection fraction had an abnormal electrical and autonomic cardiac behaviour. These findings could represent risk factors for the ocurrence of life-threatening arrhythmias or fatal events.