Liliana Rojas

Variations of lipoprotein(a) levels in the metabolic syndrome: a report from the Maracaibo City Metabolic Syndrome Prevalence Study.

Background. Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular disease, yet its influence on metabolic syndrome (MS) is still controversial. The purpose of this study was to assess the impact generated by this diagnosis in serum Lp(a) concentrations. Materials and Methods. A total of 1807 subjects of both genders (55.3% women and 44.7% men) belonging to the Maracaibo City Metabolic Syndrome Prevalence Study were evaluated. Results were expressed as Mean ± SD, determining differences through Students t-test and One-Way ANOVA test. Multiple logistic regression models were utilized for analyzing factors associated with elevated serum Lp(a) levels and MS. Total cholesterol and LDL-C were corrected according to Lp(a)-Cholesterol when necessary. Results. No differences were found in Lp(a) values between genders; P = 0,292. The association between MS and the classification of Lp(a) was statistically significant (χ 2 = 28.33; P < 0,0001), with greater levels in subjects with this diagnosis. In the univariate analysis, subjects with each of the separate diagnostic criteria showed higher serum Lp(a) concentrations, except for hyperglycemia. Conclusions. Lp(a) values exhibit important variations regarding MS and each of its components. Impaired fasting glucose appeared as a protecting factor against elevated Lp(a) concentrations, whereas its association with LDL-C and hs-CRP suggests a potential pro-inflammatory role.

439 I148M PNPLA3 VARIANT PROMOTES STEATOSIS ACCORDING TO VIRAL AND IL28B GENOTYPE BUT DOES NOT AFFECT SUSTAINED VIRAL RESPONSE IN PATIENTS WITH HEPATITIS C

439 I148M PNPLA3 VARIANT PROMOTES STEATOSIS ACCORDING TO VIRAL AND IL28B GENOTYPE BUT DOES NOT AFFECT SUSTAINED VIRAL RESPONSE IN PATIENTS WITH HEPATITIS C J. Ampuero, L. Rojas, R. Calle, L. Ortiz-Fernandez, J.R. GarciaLozano, R. Sola, X. Forns, R. Andrade, M. Diago, J.A. Pons, J.M. Navarro, R. Millan, M. Gonzalez-Escribano, M. RomeroGomez. Unit for Clinical Management of Digestive Diseases and CIBERehd, Valme University Hospital, Immunology Unit, Virgen del Rocio University Hospital, Sevilla, Hepatology Unit, Mar Hospital, Liver Unit and Ciberehd, Clinic Hospital, Barcelona, Digestive Unit and Ciberehd, Virgen de la Victoria University Hospital, Malaga, Hepatology Unit, University General Hospital, Valencia, Virgen de la Arraixaca Hospital, Murcia, Costa del Sol Hospital, Marbella, Spain E-mail: javi.ampuero@gmail.com