Limbosch Jm

Effect of jejunal resection on the gastric acid secretory response to pentagastrin, histamine and feeding in dogs.

In dogs with gastric fistulas and denervated pouches from the oxyntic area, the acid secretory responses to a meal and to graded doses of histamine and pentagastrin were measured before and after resection of the upper half of the small bowel. Intestinal resection caused a small but significant increase in submaximal and maximal response from the pouch to histamine and pentagastrin without modification of the ED50. This effect was not observed in the innervated stomach. The response from the pouch to feeding was markedly increased and prolonged. These data indicate that both an increase in stimulation and an increase of the response to this stimulation are responsible for the increased acid secretion observed in the pouch when resected dogs were fed. These effects could be explained by the withdrawal of inhibitors of intestinal origin.

Effect of insulin on acid and pepsin secretion in vagotomized and non-vagotomized patients already stimulated by pentagastrin

The effects of insulin on acid and pepsin secretion were studied in 16 non-vagotomized patients and 14 completely vagotomized patients, during the continuous intravenous infusion of pentagastrin (‘Peptavlon ICI’). In non-vagotomized patients, insulin did not alter the acid response to pentagastrin, whereas it strongly stimulated pepsin secretion. In contrast, insulin inhibited acid and pepsin secretion in vagotomized patients. The data presented suggest that after vagotomy, the inhibitory effect of insulin on acid secretion may determine the pattern of acid response during an insulin test.

Effect of small bowel resection on gastrin release, catabolism, and activity in dogs.

Abstract Effects of upper small bowel resection on acid secretion and serum gastrin concentration after infusion of exogenous gastrin or feeding were tested on three dogs with gastric fistula and Heidenhain pouch. These studies indicate that the increased acid response from the Heidenhain pouch to a meal after bowel resection is due to an increased reactivity of the parietal cells and an increase in the stimulation of these cells. These effects could be related to the removal of intestinal inhibitors acting on the parietal and G cells, or to the interruption of inhibitory neural reflexes between the small bowel and the stomach, or both.

Acid and Pepsin Secretion in Response to Insulin after Truncal Vagotomy in Man

The acid and pepsin responses to insulin stimulation were studied during 22 insulin tests on 21 vagotomized patients. In 9 tests, no rise in acid or pepsin concentration was observed within the two fi