Lin Bingcheng

Separation of enantiomers of drugs by capillary electrophoresis I. γ-cyclodextrin as chiral solvating agent

Abstract Enantiomer separation was studied for a set of 57 chiral drugs. With γ-cyclodextrin as chiral solvating agent in capillary zone electrophoresis, seven enantiomeric pairs could be separated without recoursing to an optimization procedure. Possible interaction mechanisms between selector and selectand molecules are briefly discussed.

Separation of enantiomers of drugs by capillary electrophoresis, Part 6. Hydroxypropyl-β-cyclodextrin as chiral solvating agent

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-gamma-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.

Separation of drug enantiomers by capillary electrophoresis: α-cyclodextrin as chiral solvating agent

SummaryEnantiomer separation by capillary zone electrophoresis was studied for a set of 59 chiral drugs. With α-cyclodextrin as chiral solvating agent, six enantiomeric pairs could be resolved. Baseline separation was achieved for clidinium bromide, oxomemazine and tetryzoline, whereas ketamine, orphenadrine, tropicamide and others require further optimization. Aliphatic and monocyclic compounds prevail among compounds recognized by α-cyclodextrin. Statistical analysis reveals that a medium degree of migration retardation offers the best chance for successful separation.

Simulation Dynamischer Prozesse in der Gaschromatographie

Der Wanderungsprozess von Komponenten entlang einer GC-Saule bei Anlegen eines Temperaturprogramms kann mit Hilfe unseres in Basic und Fortran77 geschriebenen Programms auf einem Personal Computer simuliert werden. Der Aufenthaltsort x (in relativen Einheiten der Saulenlange), die Geschwindigkeit dx/dt und die Beschleunigung d2x/dt2 in Abhangigkeit von der zeit t werden fur verschiedene stoffklassen untersucht und zur prazisen Vorhersage von Retentionsdaten herangezogen.