Linghang Zhuang | Researchain

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Featured researches published by Linghang Zhuang.

Proceedings of the National Academy of Sciences of the United States of America | 2004

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda; Neville J. Anthony; Robert P. Gomez; Samson M. Jolly; John S. Wai; Linghang Zhuang; Thorsten E. Fisher; Mark W. Embrey; James P. Guare; Melissa S. Egbertson; Joseph P. Vacca; Joel R. Huff; Peter J. Felock; Marc Witmer; Kara A. Stillmock; Robert Danovich; Jay A. Grobler; Michael D. Miller; Amy S. Espeseth; Lixia Jin; I-Wu Chen; Jiunn H. Lin; Kelem Kassahun; Joan D. Ellis; Bradley K. Wong; Wei Xu; Paul G. Pearson; William A. Schleif; Riccardo Cortese; Emilio A. Emini

Journal of Medicinal Chemistry | 2003

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells

Linghang Zhuang; John S. Wai; Mark W. Embrey; Thorsten E. Fisher; Melissa S. Egbertson; Linda S. Payne; James P. Guare; Joseph P. Vacca; Daria J. Hazuda; Peter J. Felock; Abigail Wolfe; Kara A. Stillmock; Marc Witmer; Gregory Moyer; William A. Schleif; Lori J. Gabryelski; Yvonne M. Leonard; Joseph J. Lynch; Stuart R. Michelson; Steven D. Young

Journal of Medicinal Chemistry | 2000

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

John S. Wai; Melissa S. Egbertson; Linda S. Payne; Thorsten E. Fisher; Mark W. Embrey; Lekhanh O. Tran; Jeffrey Y. Melamed; H. Marie Langford; James P. Guare; Linghang Zhuang; Vanessa E. Grey; Joseph P. Vacca; M. Katharine Holloway; Adel M. Naylor-Olsen; Daria J. Hazuda; Peter J. Felock; Abigail Wolfe; Kara A. Stillmock; William A. Schleif; and Lori J. Gabryelski; Steven D. Young

Bioorganic & Medicinal Chemistry Letters | 2005

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

Mark W. Embrey; John S. Wai; Timothy W. Funk; Carl F. Homnick; Debbie S. Perlow; Steven D. Young; Joseph P. Vacca; Daria J. Hazuda; Peter J. Felock; Kara A. Stillmock; Marc Witmer; Gregory Moyer; William A. Schleif; Lori J. Gabryelski; Lixia Jin; I-Wu Chen; Joan D. Ellis; Bradley K. Wong; Jiunn H. Lin; Yvonne M. Leonard; Nancy N. Tsou; Linghang Zhuang

Bioorganic & Medicinal Chemistry Letters | 2007

Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.

John S. Wai; Boyoung Kim; Thorsten E. Fisher; Linghang Zhuang; Mark W. Embrey; Peter D. Williams; Donnette D. Staas; Chris Culberson; Terry A. Lyle; Joseph P. Vacca; Daria J. Hazuda; Peter J. Felock; William A. Schleif; Lori J. Gabryelski; Lixia Jin; I-Wu Chen; Joan D. Ellis; Rama Mallai; Steven D. Young

Archive | 2001