ngjun Li
Henan Normal University
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Publication
Featured researches published by ngjun Li.
Catalysis Letters | 2015
Anlian Zhu; Shukun Bai; Lingjun Li; Mingyue Wang; Jianji Wang
AbstractIn this work, choline hydroxide is found to be an efficient and green catalyst for the synthesis of biscoumarins through the Domino Knoevenagel–Michael reaction of a series of aldehydes with 4-hydroxylcoumarin under mild conditions. A series of aldehydes with different substituted functional groups, especially those which are sensitive to acid, have been converted to biscoumarins with good to excellent isolated yields, and the reactions can be easily scaled up to multigrams. The target products can be simply separated by filtration, and the aqueous solution of choline hydroxide (as filtrate) can then be reused for the next run reaction.Graphical AbstractCholine hydroxide was found to be a green and efficient catalyst for the synthesis of biscoumarins through the Domino Knoevenagel–Michael reactions under mild conditions.
RSC Advances | 2015
Anlian Zhu; Mingyue Wang; Lingjun Li; Jianji Wang
In this work, a basic ionic liquid, tetramethylguanidium acetate ([TMG][Ac]), was found to be an efficient catalyst for the one-pot preparation of biscoumarins through a domino Knoevenagel–Michael reaction at room temperature. This novel catalytic system avoids the utilization of volatile organic solvents and has excellent tolerance to various functional groups on substrates. The convenient preparation, excellent catalytic efficiency, good reusability and the perspective in scale-up reactions make this catalyst intriguing in industrial applications.
Australian Journal of Chemistry | 2011
Lingjun Li; Yanyan Li; Ran Li; Anlian Zhu; Guisheng Zhang
In this paper, a new synthetic protocol for one-pot preparations of 5-halo-1,4-disubstituted-1,2,3-triazoles is provided by rational combination of a CuI catalyzed azide–alkyne cycloaddition (CuAAC) reaction and an oxidative halogenation reaction. CuI- N-chlorosuccinimide (NCS) and CuBr-NCS reaction systems are developed, respectively, for effective preparations of 5-iodo-1,4-disubstituted-1,2,3-triazoles and 5-bromo-1,4-disubstituted-1,2,3-trizoles under mild conditions with a high tolerance of various sensitive groups.
RSC Advances | 2014
Lingjun Li; Anlian Zhu; Yuqin Zhang; Xincui Fan; Guisheng Zhang
Fe2(SO4)3·xH2O on silica has been found to be a novel efficient catalyst for the direct nucleophilic substitution of alcohols in solvent-free conditions. In this reaction system, the alcohols can react with various nucleophilic reagents for the convenient construction of C–C bonds and C–N bonds with the benefits of high conversion, no requirement to use excessive amounts of the nucleophile, only a catalytic amount of iron catalyst required, solvent-free and benign reaction conditions, and the feasible reusability of the catalyst.
Chemistry: A European Journal | 2017
Lingjun Li; Shengqiang Ding; Yanping Yang; Anlian Zhu; Xincui Fan; Mengchao Cui; Changpo Chen; Guisheng Zhang
Iodo-1,2,3-triazoles are of considerable interest for chemical and biomedical applications. However, current synthetic methods for preparing iodo-1,2,3-triazoles cannot easily be applied to the direct modification of bioactive molecules in water. Through the combination of water-compatible oxidative iodination and the copper-catalyzed alkyne-azide cycloaddition reaction, a novel copper-catalyzed aqueous multicomponent synthetic method for the preparation of 5-iodo-1,2,3-triazoles has been developed. The method is highly effective and selective for substrates including biologically relevant compounds with nucleoside, sugar, and amino acid moieties. Based on this aqueous tandem reaction, a direct single-step multicomponent dual modification of peptide is developed from readily available starting materials. Furthermore, the method could also be applied to concise and fast multicomponent radioactive 125 I labeling from an aqueous solution of commercially available sodium 125 iodide as a starting material.
Catalysis Letters | 2017
Anlian Zhu; Wanlu Feng; Lingjun Li; Qianqian Li; Jianji Wang
AbstractIn this work, a hydroxyl functionalized Lewis acidic ionic liquid on silica is found to be an efficient heterogeneous catalyst for the C-3 Friedel-Crafts benzylation of indoles with different benzyl alcohols as benzylation agents under mild conditions. This catalytic system benefits from simple operation, work-up and reutilization procedures, wide substrate tolerance, low cost, high catalytic activity and excellent chemo-selectivity. The hybrid combination of hydroxyl functionalized ionic liquid and silica through the formation of hydrogen bond endows this catalyst with high stability in the Friedel-Crafts reaction system, and the catalyst could be easily recycled and reutilized.Graphical AbstractA hydroxyl functionalized Lewis acid ionic liquid supported on silica was found to be an efficient catalyst for the C-3 Friedel-Crafts benzylation reaction of iodole with alcohols. This catalyst benefits from low cost, feasible preparation and reutilization, high catalytic activity and selectivity, and the operation and work-up procedures are very simple.
RSC Advances | 2017
Anlian Zhu; Ruixia Liu; Chunyan Du; Lingjun Li
In this study, a series of betainium-based ionic liquids with various anions have been synthesized and their catalytic performances for the Hantzsch reactions have been investigated. It is shown that these ionic liquids have high selectivity for the one-pot production of acridinediones through Hantzsch reactions under mild conditions, and betainium lactate has the highest catalytic activity. This ionic liquid catalyst is very cheap and easy to prepare; the catalytic procedure is very simple and the catalyst can be recycled and reutilized. In addition, the biocompatibility of the raw material of these ionic liquids suggests that this catalytic system may have great industrial potential applications.
Journal of Chemical Research-s | 2010
Lingjun Li; Anlian Zhu; Huiwen Yao; Yujing Wei; Di Yang; Jian-Ping Li; Guisheng Zhang
A mild and efficient method for the formation of C–N bonds is reported with SnCl4 as an inexpensive catalyst. With 10 mol% of SnCl4, the direct substitution reaction of secondary benzyl alcohols with a sulfonamide, a carboxamide, 4-nitroaniline and an azide proceeds well in good to excellent yields at room temperature.
Molecules | 2017
Lingjun Li; Qianqian Li; Shengqiang Ding; Pengyang Xin; Yuqin Zhang; Shenlong Huang; Guisheng Zhang
Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates. However, the synthesis of ADP-ribosylated compounds is currently difficult due to structural complexity, easily broken pyrophosphate bond and high hydrophilicity. In this paper, ADP-ribosyl-N3 was designed and synthesized for the first time. With ADP-ribosyl-N3 as the key precursor, a divergent post-modification strategy was developed to prepare structurally diverse ADP-ribosylated compounds including novel nucleotides and peptides bearing ADP-ribosyl moieties.
Sustainable Catalytic Processes | 2015
Jianji Wang; Anlian Zhu; Lingjun Li
Abstract In this chapter, an attempt is made to review the physicochemical properties of ionic liquids and their utilization in several catalysis procedures including transition metal catalysis, enzymatic reactions, dissolution and conversion of biomass, and CO2 transformation. The relationship between structures, physicochemical properties of ionic liquids and their contribution to the sustainability of the related processes is discussed. Also, some representative reactions promoted by acidic and basic functionalized ionic liquids have been reviewed. It is suggested that the combination of cations and anions can provide versatile reaction media and catalysts for the sustainable processes although the rational design of ionic liquids for a particular process is still in its infancy.