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Dive into the research topics where Lionel Cusan is active.

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Featured researches published by Lionel Cusan.


Fertility and Sterility | 1978

Inhibitory Effect of a Luteinizing Hormone (LH)-Releasing Hormone Agonist on Rat Ovarian LH and Follicle-Stimulating Hormone Receptor Levels During Pregnancy

Gary S. Kledzik; Lionel Cusan; Claude Auclair; Paul A. Kelly; Fernand Labrie

When injected at the daily dose of 100 microgram on days 7 through 12 of pregnancy, the luteinizing hormone (LH)-releasing hormone (LHRH) agonist [D-Ala6, des-Gly-NH2(10)] LHRH ethylamide led to complete suppression of pregnancy and a 45% to 60% decrease in plasma progesterone concentration. The antifertility effect of the LHRH analog was accompanied by an early and almost complete inhibition of ovarian LH/human chorionic gonadotropin and follicle-stimulating hormone receptor levels. These data suggest that the antifertility effects of LHRH agonists are mediated by down-regulation of ovarian gonadotropin receptors and decreased luteal function.


Molecular and Cellular Endocrinology | 1978

Evidence for a role of endorphins in stress- and suckling-induced prolactin release in the rat

Louise Ferland; Gary S. Kledzik; Lionel Cusan; Fernand Labrie

Injection of the opiate antagonist naloxone completely prevented the rise of serum prolactin induced by ether stress in intact male rats. Naloxone also led to a 50--95% inhibition of the marked elevation of plasma prolactin levels induced by suckling. These data suggest that endogenous opiates (endorphins) are involved in the stimulation of prolactin release induced by both stress and suckling in the rat.


The Journal of Clinical Endocrinology and Metabolism | 1994

Changes in Serum Concentrations of Conjugated and Unconjugated Steroids in 40- to 80,Year-Old Men

Alain Bélanger; Bernard Candas; André Dupont; Lionel Cusan; Pierre Diamond; José-Luis Gomez; Fernand Labrie


The Journal of Clinical Endocrinology and Metabolism | 1997

Physiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But of Their Metabolites: Intracrinology

Fernand Labrie; Alain Bélanger; Lionel Cusan; Bernard Candas


Endocrinology | 1979

Inhibitory effects of long term treatment with a luteinizing hormone-releasing hormone agonist on the pituitary-gonadal axis in male and female rats.

Lionel Cusan; Claude Auclair; Alain Bélanger; Louise Ferland; Paul A. Kelly; Carl Séguin; Fernand Labrie


Endocrinology | 1978

Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, Des-Gly-NH210] LHRH ethylamide.

Georges Pelletier; Lionel Cusan; Claude Auclair; Paul A. Kelly; L. Désy; Fernand Labrie


Biology of Reproduction | 1980

Effect of an LHRH Agonist and hCG on Testicular Steroidogenesis in the Adult Rat

Alain Bélanger; Lionel Cusan; C. Auclair; Carl Séguin; Simon Caron; Fernand Labrie


Biology of Reproduction | 1981

Relative Importance of the Adenohypophyseal and Gonadal Sites of Inhibitory Action of LHRH Agonists

Carl Séguin; Alain Bélanger; Lionel Cusan; Georges Pelletier; Jerry J. Reeves; Fleur-Ange Lefebvre; Paul A. Kelly; Fernand Labrie


Control of Ovulation | 1978

5 – SPECIFIC MODULATION OF LH-RH ACTION ON LH AND FSH SECRETION BY GONADAL STEROIDS

Fernand Labrie; Lisette Lagacé; Jacques Drouin; Louise Ferland; Paul A. Kelly; Lionel Cusan


Receptors#R##N#Proceedings of the 7th International Congress of Pharmacology, Paris, 1978 | 1979

Control of Hormone Receptor Levels and Function

Fernand Labrie; Claude Auclair; André De Léan; Michèle Beaulieu; Louise Ferland; Vincent Raymond; Paul A. Kelly; Lionel Cusan; Lisette Lagacé; Jacques Drouin; Jocelyne Massicotte

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Fernand Labrie

Medical Research Council

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Claude Auclair

Medical Research Council

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Louise Ferland

Medical Research Council

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Carl Séguin

Medical Research Council

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Jacques Drouin

Medical Research Council

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