Lionel N. Simon

Adenosine 3′,5′-cyclic monophosphate derivatives II. Biological activity of some 8-substituted analogs

Abstract Several 8-substituted derivatives of adenosine 3′,5′-cyclic monophosphate have been shown to stimulate the ATP-dependent phosphorylation of histone by purified bovine brain and liver protein kinase as well as to stimulate glycogenolysis in rat liver slices. The results indicate that a series of 8-substituted analogs which have varying activation constants (Ka values) for the bovine kinases, have the same order of relative potency as stimulators of glycogenolysis in liver slices.