Lis Skovsted
Frederiksberg Hospital
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Lis Skovsted.
Clinical Pharmacology & Therapeutics | 1971
J. Mølholm Hansen; Kaj Siersbæk-Nielsen; Lis Skovsted
Diphenylhydantoin half‐life was determined in 5 patients before and during treatment with carbamazepine. It caused a significant decrease in the diphenylhydantoin half‐life from 10.6 hours to 6.4 hours. Seven patients who for a period had been given diphenylhydantoin were also started on carbamazepine. This resulted in a fall in serum diphenylhydantoin levels in 3 of the patients. Alterations in warfarin half‐life, serum warfarin, and plasma prothrombin‐proconvertin concentration during carbamazepine treatment were compatible with a stimulation of warfarin metabolism. The effect of carbamazepine on diphenylhydantoin and warfarin metabolism is probably explained by an induction of the drug‐metabolizing enzyme system in the liver.
Clinical Pharmacokinectics | 1981
Bodil Bach; J. Mølholm Hansen; J. P. Kampmann; S. N. Rasmussen; Lis Skovsted
SummaryThe half-life and metabolic clearance rale (MCR) of antipyrine and phenytoin were determined in 14 young [mean age: 28.8 ± 8.3 (SD) years] and in 14 elderly [mean age: 83.5 ±7.1 (SD) years] subjects and correlated with liver volume, which was determined by ultrasonic scanning, to see if an age-dependent difference in drug metabolism could be explained by a reduced liver weight with age.The size of the liver was smaller in the elderly subjects even when related to decreased body surface. A significant decrease in serum albumin in the elderly compared with the younger group was also noted. The half-life of antipyrine was significantly longer in the elderly than in the younger group, 756 ± 318 and 465 ± 110 minutes, respectively, and the MCR was correspondingly lower in the elderly even when calculated per litre of liver volume, 22.8 ± 7.8 and 36.3 ± 8.9ml/minute/L liver volume, respectively. No significant differences in the 2 age groups were found in half-life and total clearance of phenytoin, but a reduced free phenytoin clearance was demonstrated in the elderly (240 ± 92ml/minute/L liver volume) compared with the younger (325 ± 81 ml/minute/L liver volume) group. No significant correlation was found between liver volume and the half-life of antipyrine and phenytoin. However, a significant correlation was demonstrated between liver volume and MCR of antipyrine as well as between total and free clearance of phenytoin. No correlation was found between the half-lives of the 2 drugs, while a significant correlation existed between the clearance values.It is suggested that the age-dependent reduction in drug clearance is due not only to a smaller liver volume, but is also a result of a reduced capacity of the liver microsomes per unit of liver in the elderly. With regard to age-dependent changes in drug metabolism, the protein binding of the actual drug has to be taken into consideration.
Clinical Pharmacology & Therapeutics | 1975
Bo Lumholtz; Siersbaek‐Nielsen Kaj; Lis Skovsted; Jens P. Kampmann; Jens Mølholm Hansen
The influence of sulfamethizole on the metabolism of diphenylhydantoin (DPH), tolbutamide, and warfarin is examined. In 8 patients DPH mean half‐life (T/2) increased from 11.8 ± 3.3 hr to 19.6 ± 5.2 hr and mean metabolic clearance rate (MCR) decreasedfram 43.7 ± 16.8 to 28.1 ± 9.1 ml/min during sulfamethizole treatment. In 6 patients mean tolbutamide T/2 increased from 5.7 ± 1.2 to 9.2 ± 1.2 hr MCR decreased from 17.0 ± 5.4 to 10.5 ± 1.2 ml/min. In 2 patients warfarin T/2 increased from an average of 64.7 to 92.7 hr and MCR decreased from 1.65 ml/min to 1.05 ml/min. In 4 patients on long‐term DPH treatment after 1 wk on sulfamethizole, there was an increase in serum DPH concentration in 3. It is suggested that sulfamethizole inhibits hepatic metabolism of DPH, tolbutamide, and warfarin.
The Journal of Clinical Endocrinology and Metabolism | 1974
J. Mølholm Hansen; Lis Skovsted; U. Birk Lauridsen; C. Kirkegaard; K. Siersæk-Nielsen
European Journal of Endocrinology | 1975
Jens Mølholm Hansen; Lis Skovsted; Kaj Siersbæk-Nielsen
Acta Medica Scandinavica | 2009
J. Mølholm Hansen; Kaj Siersbæk-Nielsen; M. Kristensen; Lis Skovsted; L. Korsgaard Christensen
Acta Medica Scandinavica | 2009
J. Mølholm Hansen; Jens P. Kampmann; Kaj Siersbæk-Nielsen; I. B. Lumholtz; M. Arrøe; U. Abildgaard; Lis Skovsted
European Journal of Endocrinology | 1979
Peter Theilade; Jens Mølholm Hansen; Lis Skovsted; Jens P. Kampmann
European Journal of Endocrinology | 1978
Karine Bech; Lis Skovsted; Kaj Siersbæk-Nielsen; Jens Mølholm Hansen
European Journal of Endocrinology | 1978
Klaus Johansen; Jens Mølholm Hansen; Lis Skovsted