Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Lisa Grandinetti is active.

Publication


Featured researches published by Lisa Grandinetti.


Dermatologic Clinics | 2015

Cutaneous Manifestations of Crohn Disease

Joshua W. Hagen; Jason M. Swoger; Lisa Grandinetti

Awareness of the extraintestinal manifestations of Crohn disease is increasing in dermatology and gastroenterology, with enhanced identification of entities that range from granulomatous diseases recapitulating the underlying inflammatory bowel disease to reactive conditions and associated dermatoses. In this review, the underlying etiopathology of Crohn disease is discussed, and how this mirrors certain skin manifestations that present in a subset of patients is explored. The array of extraintestinal manifestations that do not share a similar pathology, but which are often seen in association with inflammatory bowel disease, is also discussed. Treatment and pathogenetic mechanisms, where available, are discussed.


Journal of Cutaneous Pathology | 2016

Langerhans cell histiocytosis and Erdheim-Chester disease, both with cutaneous presentations, and papillary thyroid carcinoma all harboring the BRAF(V600E) mutation.

William T. Johnson; Parth Patel; Amanda Hernandez; Lisa Grandinetti; Arthur Huen; Stanley M. Marks; Jonhan Ho; Sara E. Monaco; Ronald Jaffe; Jennifer Picarsic

Langerhans cell histocytosis (LCH) and Erdheim‐Chester disease are two rare histiocytic disorders. Their occurrence in the same patient is more infrequent, but has been described. We report a case of a 38‐year‐old woman who presented with a diagnosis of single system cutaneous LCH. Subsequently, she developed multiple papules on her extremities consistent with a non‐LCH xanthogranuloma type lesion. BRAFV600E mutation immunostain, VE1 was positive in the skin lesion, which was confirmed by molecular polymerase chain reaction (PCR) studies, initiating a complete systemic workup for Erdheim‐Chester disease. Systemic involvement was confirmed with bilateral sclerotic bone lesions and retroperitoneal and pelvic fibrosing disease. She was also found to have a BRAFV600E mutation positive papillary thyroid carcinoma. New suspicious cutaneous lesions presenting in patients with a history of LCH need to be biopsied. A BRAFV600E mutation in a non‐LCH histiocytic lesion with a xanthogranuloma phenotype (CD163/CD68/CD14/fascin/Factor 13a) should prompt an Erdheim‐Chester disease workup. This is a unique case of a woman with BRAFV600E mutation positive Erdheim‐Chester disease and cutaneous LCH, while also being, to our knowledge, the first reported case in the English literature of it occurring in a patient with a BRAFV600E mutation positive papillary thyroid carcinoma.


Journal of The American Academy of Dermatology | 2017

A cross-sectional study of indoor tanning use among patients seeking skin cancer screening

Ryan Andrulonis; Aaron M. Secrest; Timothy Patton; Lisa Grandinetti; Laura K. Ferris

Cancer and Population Studies Group and Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Australia; and Institute of Cardiovascular and Cell Sciences (Dermatology Unit), St George’s University of London, and CRUK (Cancer Research United Kingdom) Manchester Institute and Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Sciences Center, United Kingdom.


American Journal of Dermatopathology | 2016

Fatal Case of Primary Cutaneous Aggressive T-Cell Lymphoma Switching From a CD4+ to a CD8+ Phenotype: Progressive Disease With Bexarotene and Romidepsin Treatment.

William T. Johnson; Rebecca J. Leeman-Neill; Parth Patel; Jonhan Ho; Lisa Grandinetti; Jaroslaw Jedrych; Fiona E. Craig

Abstract:A 77-year-old white male presented to the clinic with two isolated cutaneous tumors on his forehead. A cutaneous biopsy showed a focally folliculotropic CD4+ cutaneous lymphoma. The tumors were irradiated with a complete response, and he was started on oral bexarotene. He experienced localized cutaneous relapse 3 months into treatment. These new tumors now revealed a surprisingly CD8+ cytotoxic phenotype, but with the same clone. A systemic workup was negative. His regimen was switched to romidepsin, and he was treated with local radiation again. Another 3.5 months passed in remission until he developed widespread cutaneous tumors. Positron emission tomography/computed tomography revealed multifocal systemic disease involving his diaphragm, liver, distal duodenum, proximal jejunum, anterior chest wall including pectoral muscles, and lungs without significant adenopathy. He died a few days later. Given his full clinical and pathological course, he was given the diagnosis of an aggressive primary cutaneous T-cell lymphoma, unspecified.


Archive | 2015

Connective Tissue Disorders

Joseph; Arthur Huen; Timothy Patton; Lisa Grandinetti


Archive | 2015

Neutrophilic and Eosinophilic Disorders

Joseph; Arthur Huen; Timothy Patton; Lisa Grandinetti


Archive | 2015

Calcifying, Perforating, and Atrophic Disorders

Joseph; Arthur Huen; Timothy Patton; Lisa Grandinetti


Archive | 2015

Genetic Paraneoplastic Disorders

Joseph; Arthur Huen; Timothy Patton; Lisa Grandinetti


Archive | 2015

Skin Findings with Systemic Associations

Joseph; Arthur Huen; Timothy Patton; Lisa Grandinetti


Archive | 2015

Metabolic and Nutritional Disorders

Joseph; Arthur Huen; Timothy Patton; Lisa Grandinetti

Collaboration


Dive into the Lisa Grandinetti's collaboration.

Top Co-Authors

Avatar

Arthur Huen

University of Pittsburgh

View shared research outputs
Top Co-Authors

Avatar

Timothy Patton

University of Pittsburgh

View shared research outputs
Top Co-Authors

Avatar

Jonhan Ho

University of Pittsburgh

View shared research outputs
Top Co-Authors

Avatar

Parth Patel

University of Pittsburgh

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge