Lisa L. Zacher

The Prevalence and Impact of Respiratory Symptoms in Asthmatics and Nonasthmatics during Deployment

OBJECTIVE The purpose of this study was to compare the prevalence, severity, and impact of respiratory symptoms in asthmatics and nonasthmatics during Operation Enduring Freedom and Operation Iraqi Freedom. METHODS A survey was given to 1,250 active duty soldiers and Department of Defense contractors returning from Operation Enduring Freedom/Operation Iraqi Freedom. Subjects were asked about demographics, smoking habits, respiratory symptoms, and impact on job performance before and during deployment. Patients with a history of asthma were asked method of diagnosis, current symptoms, and asthma therapy. RESULTS A total of 1,193 subjects returned the completed questionnaire (95% response rate). Mean age of respondents was 38 +/- 11 years, 83% (n = 977) were male, and 31% (n = 375) were past or present smokers. Sixty-one subjects (5%) reported a previous diagnosis of asthma. Both asthmatics and nonasthmatics had increased respiratory symptoms of wheezing, cough, sputum production, chest pain/tightness, and allergy symptoms during deployment compared to predeployment (p < 0.05 for all). When compared to nonasthmatics, asthmatic subjects reported more wheezing, sputum production, and chest pain/tightness during deployment (p < 0.0001, 0.05, 0.05 respectively), had more difficulty with military duties (p < 0.05), and were more likely to seek medical attention and receive duty restrictions (p < 0.0001). Twenty-six percent (n = 16) of asthmatics reported poor baseline symptom control, and this group had significantly increased symptoms, functional limitations, and health care utilization when compared to asthmatics who were symptom-controlled at baseline. CONCLUSIONS Respiratory symptoms were common among both asthmatics and nonasthmatics during deployment. Differences in symptoms and health care utilization in this group of asthmatics were primarily due to subjects with poor baseline control.

Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures (STAMPEDE)

RATIONALE Because of increased levels of airborne particulate matter in Southwest Asia, deployed military personnel are at risk for developing acute and chronic lung diseases. Increased respiratory symptoms are reported, but limited data exist on reported lung diseases. OBJECTIVES To evaluate new respiratory complaints in military personnel returning from Southwest Asia to determine potential etiologies for symptoms. METHODS Returning military personnel underwent a prospective standardized evaluation for deployment-related respiratory symptoms within 6 months of returning to their duty station. MEASUREMENTS AND MAIN RESULTS Prospective standardized evaluation included full pulmonary function testing, high-resolution chest tomography, methacholine challenge testing, and fiberoptic bronchoscopy with bronchoalveolar lavage. Other procedures including lung biopsy were performed if clinically indicated. Fifty patients completed the study procedures. A large percentage (42%) remained undiagnosed, including 12% with normal testing and an isolated increase in lavage neutrophils or lymphocytes. Twenty (40%) patients demonstrated some evidence of airway hyperreactivity to include eight who met asthma criteria and two with findings secondary to gastroesophageal reflux. Four (8%) additional patients had isolated reduced diffusing capacity and the remaining six had other miscellaneous airway disorders. No patients were identified with diffuse parenchymal disease on the basis of computed tomography imaging. A significant number (66%) of this cohort had underlying mental health and sleep disorders. CONCLUSIONS Evaluation of new respiratory symptoms in military personnel after service in Southwest Asia should focus on airway hyperreactivity from exposures to higher levels of ambient particulate matter. These patients may be difficult to diagnose and require close follow-up.

Intensive Education on Evidence-Based Evaluation of Syncope Increases Sudden Death Risk Stratification but Fails to Reduce Use of Neuroimaging

BACKGROUND We sought to determine whether aggressive education on evidence-based guidelines would affect the use of resources. Specifically, we sought to educate providers about the role of neuroimaging as well as sudden death risk stratification. METHODS We reviewed 1092 consecutive cases involving patients who were admitted for syncope. We retrospectively reviewed 30 months of admissions for baseline characteristics and then initiated an intensive monthly education campaign directed toward internal medicine physicians-in-training focusing on evidence-based guidelines for a 13-month period. RESULTS There were 721 patients (66.0%) evaluated before the education intervention and 371 patients (34.0%) evaluated after the education intervention. After the intervention, there was no change in the use of computed tomography (52.3% vs 55.5%; P = .31) or magnetic resonance imaging (20.2% vs 16.7%; P = .16) of the head or carotid ultrasonography (4.7% vs 6.2%; P = .30). The referral rate for electrophysiologic study significantly increased from 6.4% at baseline to 11.3% (P = .006) after intervention, with an overall diagnostic yield of 28.4%. Of those with identified structural heart disease, the referral rate went from 5.7% to 19.0% (P = .03). Only 66 of 1092 patients who presented with syncope ultimately required a pacemaker or defibrillator implantation during hospitalization. CONCLUSIONS With intensive education, there was no decrease in neuroimaging, despite a low diagnostic yield. We were able to increase sudden death risk stratification using electrophysiologic studies without evidence of overuse of implantable device-based therapy. Intensive education allows increased adherence to guidelines for mortality reduction; however, further attempts to reduce the lower yield imaging will require methods other than education of hospital-based physicians.

The Demonstration of Pulmonary Neuroendocrine Cell Hyperplasia with Tumorlets in a Patient with Chronic Cough and a History of Multiple Medical Problems

A 58-year-old woman presented with chronic cough felt to be multifactorial secondary to asthma, gastroesophageal reflux disease, and chronic sinusitis. Additional medical history included obstructive sleep apnea, type 2 diabetes, and hypertension. She had a 40- year history of tobacco use, but quit 10 years ago. Her examination was significant for obesity and cobble stoning of the oropharynx. Pulmonary function testing and arterial blood gases were unrevealing. Chest films were normal. High-resolution computed tomography revealed multiple focal lucencies in a mosaic pattern consistent with air trapping and small airways disease. Bronchoscopy revealed normal airways and a noninflammatory bronchoalveolar lavage. Transbronchial biopsies revealed inflammatory infiltrates of the peribronchiolar interstitium. Lung biopsy revealed pulmonary neuroendocrine cell hyperplasia with tumorlets that stained positive for neuroendocrine tissue. We present the case of a woman with chronic cough, multiple medical problems, and pulmonary neuroendocrine cell hyperplasia with tumorlets.

Determination of the Internal Medicine Service’s Role in Emergency Department Length of Stay at a Military Medical Center

OBJECTIVES Increasing numbers of emergency department (ED) visits and higher leaving-without-being-seen rates resulted in an evaluation of the contribution of the internal medicine service to the admission process. METHODS Standardized ED encounter sheets were completed by the medicine physician on duty (MOD) assessing various admission and consultative parameters. RESULTS 304 patient encounters revealed a 44-minute mean time from MOD consultation to order submission; 49% in under 30 minutes and 76% in under an hour. There was no difference in time among MOD shifts, staff and residents, or admission diagnoses. Reasons for delays were receiving multiple consults at a time (36%) and needing further specialty consultation or additional workup (30%). CONCLUSIONS Most medicine admissions took less than an hour from time of MOD consultation to time orders were written. Areas of improvement include expediting discussion with specialists and timely but appropriate ED workup before consultation.

Prevalence of Supranormal Pulmonary Function Test Values Between a Military and Nonmilitary Cohort

BACKGROUND: The study objective was to determine differences in the proportion of supranormal pulmonary function tests (PFTs) between active duty (AD) military personnel and a similar non-active duty (non-AD) population. Given the emphasis on cardiovascular fitness in the military, it has been hypothesized that regular exercise in this cohort leads to an increased proportion of supranormal PFTs. We hypothesized that a comparison of PFTs would identify no differences in the ratio of supranormal to normal PFTs between the AD and non-AD populations. METHODS: A retrospective chart review was conducted of all PFT studies at the Brooke Army Medical Center from 2006 to 2011. Studies were included with either an FVC or FEV1 > 110% of predicted, with both values > 100% of predicted. A comparative analysis was performed for patients between 18 and 50 years of age based on AD status. Further analysis was performed on all ages to determine the distribution of supranormal findings in the entire study population. RESULTS: A total of 16,600 interpreted PFTs were queried. Of those, 4,303 (31.6%) were AD patients, and 9,306 (68.4%) were non-AD patients. From all of the PFTs reviewed, a total of 912 (6.7%) were identified as supranormal. When further analyzed, 381 (9.4%) of AD patients 18–50 years old were supranormal, 175 (12.4%) of non-AD patients 18–50 years old were supranormal, and 356 (4.7%) of non-AD patients older than 50 years were supranormal. CONCLUSIONS: This study revealed no significant difference in the proportion of supranormal-to-normal PFTs in an AD versus non-AD duty population of the same age range. Based on these findings, no assumption should be made that supranormal PFTs are more common in military personnel. Interpretation of normal PFTs in AD personnel undergoing evaluation should not differ from that in any typical patient.