Lisa S. Silverman
Merck & Co.
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Publication
Featured researches published by Lisa S. Silverman.
Bioorganic & Medicinal Chemistry Letters | 2012
Stephanie Brumfield; Peter Korakas; Lisa S. Silverman; Deen Tulshian; Julius J. Matasi; Li Qiang; Chad E. Bennett; Duane A. Burnett; William J. Greenlee; Chad E. Knutson; Wen-Lian Wu; T.K. Sasikumar; Martin Domalski; Rosalia Bertorelli; Mariagrazia Grilli; Gianluca Lozza; Angelo Reggiani; Cheng Li
High throughput screening identified the pyridothienopyrimidinone 1 as a ligand for the metabotropic glutamate receptor 1 (mGluR1=10 nM). Compound 1 has an excellent in vivo profile; however, it displays unfavorable pharmacokinetic issues and metabolic stability. Therefore, using 1 as a template, novel analogues (10i) were prepared. These analogues displayed improved oral exposure and activity in the Spinal Nerve Ligation (SNL) pain model.
Archive | 2002
Bernard R. Neustadt; Neil Lindo; William J. Greenlee; Deen Tulshian; Lisa S. Silverman; Yan Xia; Craig D. Boyle; Samuel Chackalamannil
Journal of Medicinal Chemistry | 1997
Ho-Sam Ahn; Ana Bercovici; George Boykow; Alan Bronnenkant; Samuel Chackalamannil; Jason Chow; Renee Cleven; John A. Cook; Michael Czarniecki; Carol Domalski; Ahmad Fawzi; Michael V. Green; Asli Gündes; Ginny D. Ho; Malvina Laudicina; Neil Lindo; Ke Ma; Mahua Manna; Brian Mckittrick; Bita Mirzai; Terry Nechuta; Bernard R. Neustadt; Chester Puchalski; Kathryn Pula; Lisa S. Silverman; Elizabeth M. Smith; Andrew Stamford; Richard P. Tedesco; Hsingan Tsai; Deen Tulshian
Archive | 1999
Deen Tulshian; Ginny D. Ho; Lisa S. Silverman; Julius J. Matasi; Robbie L. McLeod; John A. Hey; Richard W. Chapman; Ana Bercovici; Francis M. Cuss
Archive | 2002
Deen Tulshian; Lisa S. Silverman; Julius J. Matasi; Eugenia Y. Kiselgof; John P. Caldwell
Archive | 2005
Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Thavalakulamgara K. Sasikumar; Li Qiang; Martin Domalski
Archive | 2006
Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Sasikumar K. Thavalakulamgara; Li Qiang; Martin Domalski
Archive | 2006
Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Sasikumar K. Thavalakulamgara; Li Qiang; Martin Domalski
Archive | 2005
Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Thavalakulamgara K. Sasikumar; Li Qiang; Martin Domalski
Archive | 2002
Deen Tulshian; Lisa S. Silverman; Julius J. Matasi; Eugenia Y. Kiselgof; John P. Caldwell
Collaboration
Dive into the Lisa S. Silverman's collaboration.
