Lisette Justino

Visual retinocortical function in dementia of the Alzheimer type

Background: Some histological investigations have reported anomalies in the primary visual pathways of individuals with dementia of the Alzheimer type (DAT), while others have suggested that these visual structures are spared by the disease process. Objectives: This study was conducted to address this issue of substantial controversy. We determined in vivo whether DAT alters the functioning of the primary visual pathways by evaluating pattern-reversal electroretinograms (ERGs) and cortical visual evoked potentials (VEPs). Methods: Twenty-seven individuals with mild to moderate DAT and 27 age- and sex-matched control subjects were included in the investigation. ERG and VEP recordings were obtained from all participants with the use of a clinical electrodiagnostic system. Stimulus conditions were biased towards a preferential response from the magnocellular and parvocellular subdivisions of the visual system. Results: Amplitude and latency of the ERG were not affected by DAT. The VEP amplitude was not attenuated in DAT individuals, but there was a delay in the latency of the VEPs arising from both magnocellular and parvocellular streams of visual processing. Conclusion: Our results indicate that while the inner retina appears to be spared by the disease process, the visual function is altered upstream in the retinocortical visual pathways of individuals with DAT.

Neuroretinal function is normal in early dementia of the Alzheimer type

We recently demonstrated that retinal ganglion cell function, optic nerve head parameters and the retinal nerve fiber layer thickness are not altered in early dementia of the Alzheimer type (DAT). Our current objective was to assess whether the function of cells located more distally in the retina is also unaffected by the disease. We evaluated 23 individuals with early to moderate DAT and 23 healthy age-matched subjects, all displaying clinically normal visual function. Scotopic and photopic flash electroretinograms (fERGs) and oscillatory potentials (OPs) were recorded. The amplitude and latency of the retinal potentials did not differ between DAT and control subjects. Our current results showing normal fERGs and OPs in early DAT indicate that the underlying neurons giving rise to these signals are not impaired by the disease process. These data support and extend our recent findings suggesting that visual deficits in DAT do not stem from neuroretinal dysfunction.

Changes in the retinocortical evoked potentials in subjects 75 years of age and older

OBJECTIVE Current trends are showing a rapid increase in the elderly population, particularly the subgroup that is 75 years of age or more. Considering the fact that several ocular diseases are more prevalent among the elderly, it is increasingly important to investigate normal visual function in this subgroup of our population. The objective of this study was to determine the effects of advanced aging on visual retinocortical function by evaluating the electrophysiological responses of the most rapidly increasing segment of the geriatric population. METHODS Fifty-eight healthy subjects between the ages of 20--32 years (n=30) and 75--88 years (n=28) participated in this study. We recorded their pattern electroretinograms (ERGs) and cortical visual evoked potentials (VEPs) under stimulus conditions biased toward the preferential response of the magnocellular and parvocellular subdivisions of the visual system. RESULTS Elderly subjects showed reduced ERG amplitudes relative to young participants. The amplitude of the VEPs also decreased with age, while their latency increased. The effect of senescence was most apparent under stimulus conditions combining the magnocellular and parvocellular pathway contributions and less pronounced when the stimulus conditions were biased to favor the response of either system. CONCLUSIONS Our results demonstrate that visual retinal and cortical function deteriorates with old age. Our data further indicate that senescence has widespread effects on the visual system, altering the functioning of both the magnocellular and parvocellular visual pathways.

Normal optic nerve head topography in the early stages of dementia of the Alzheimer type

In view of the existing controversy as to whether or not the optic nerve head (ONH) is altered in Alzheimer disease, we used modern imaging technology to evaluate the ONH structure in individuals with dementia of the Alzheimer type (DAT). Real-time topographical images of the ONH were obtained with a Heidelberg retina tomograph from individuals in the early stages of DAT and age-matched controls. The various ONH parameters examined in this study did not differ significantly between DAT and age-matched subjects. These results suggest that the deficits in visual function that are known to occur in DAT are not related to ONH structural anomalies, at least in the earlier stages of the disease.

Age-related changes in the flash electroretinogram and oscillatory potentials in individuals age 75 and older

To evaluate whether the inner plexiform layer of the retina is altered during senescence by examining the oscillatory potentials (OPs) of the flash electroretinogram (fERG) in individuals age 75 and older.

Age-related topographical changes in the normal human optic nerve head measured by scanning laser tomography.

Purpose. This study was designed to investigate the effects of advanced aging on the optic nerve head (ONH) structure and retinal nerve fiber layer (RNFL) thickness in the eldest segment of our population. Methods. Twenty-seven healthy elderly subjects between 75 and 88 years of age (average, 80.1 ± 0.83 years) and 30 healthy younger subjects between 20 and 32 years of age (average, 23.1 ± 0.50 years) were recruited for a cross-sectional comparison between ONH morphology and RNFL thickness as measured by scanning laser tomography. The ONH disc, cup, and rim areas; cup-to-disc ratio; and the mean thickness of the RNFL were quantified. Results. The cup and disc areas as well as the cup-to-disc area ratio increased with age, whereas the RNFL thickness decreased during the course of normal senescence. Conclusions. Any diagnoses of ocular pathology in the elderly must differentiate the effects of normal aging on the ONH topography and RNFL thickness. To that effect, the present study provides a clinical profile of ocular structures that extend into the oldest geriatric age group.