Lloyd J. Payne

Parallel synthesis of 1,2,4-trisubstituted imidazoles via N-alkyl-N-(β-keto)amides using a carbazate linker

Abstract The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N -alkyl- N -(β-keto)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N -alkyl- N -(β-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solution using NH 4 OAc led to the preparation of 1400 1,2,4-trisubstituted imidazoles.

Direct release of nitriles from solid phase

Abstract Cleavage conditions are described which allow resin bound secondary amides to be liberated from Sieber or Rink resin as nitriles. The method has been applied to the synthesis of a series of cyanobiaryls.