Lok Wai Lawrence Woo
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Featured researches published by Lok Wai Lawrence Woo.
Journal of Medicinal Chemistry | 2010
Lok Wai Lawrence Woo; Toby Jackson; A Putey; Gyles E. Cozier; P Leonard; K.R Acharya; Surinder K. Chander; Atul Purohit; Michael J. Reed; Barry V. L. Potter
Single agents against multiple drug targets are of increasing interest. Hormone-dependent breast cancer (HDBC) may be more effectively treated by dual inhibition of aromatase and steroid sulfatase (STS). The aromatase inhibitory pharmacophore was thus introduced into a known biphenyl STS inhibitor to give a series of novel dual aromatase-sulfatase inhibitors (DASIs). Several compounds are good aromatase or STS inhibitors and DASI 20 (IC(50): aromatase, 2.0 nM; STS, 35 nM) and its chlorinated congener 23 (IC(50): aromatase, 0.5 nM; STS, 5.5 nM) are examples that show exceptional dual potency in JEG-3 cells. Both biphenyls share a para-sulfamate-containing ring B and a ring A, which contains a triazol-1-ylmethyl meta to the biphenyl bridge and para to a nitrile. At 1 mg/kg po, 20 and 23 reduced plasma estradiol levels strongly and inhibited liver STS activity potently in vivo. 23 is nonestrogenic and potently inhibits carbonic anhydrase II (IC(50) 86 nM). A complex was crystallized and its structure was solved by X-ray crystallography. This class of DASI should encourage further development toward multitargeted therapeutic intervention in HDBC.
Anti-cancer Drug Design | 2001
Lynn Wood; Matthew Paul Leese; Bertrand Leblond; Lok Wai Lawrence Woo; Dharshini Ganeshapillai; Atul Purohit; Michael J. Reed; Barry V. L. Potter; Graham Packham
Biochemistry | 2005
Matthew D. Lloyd; Nethaji Thiyagarajan; Yaik T. Ho; Lok Wai Lawrence Woo; Oliver B. Sutcliffe; Atul Purohit; Michael J. Reed; K.R Acharya; Barry V. L. Potter
Archive | 2002
Barry V. L. Potter; Lok Wai Lawrence Woo; Atul Purohit; Michael J. Reed; Christian Bubert; Oliver B. Sutcliffe
Archive | 2006
Barry Victor Lloyd Potter; Michael John Reed; Lok Wai Lawrence Woo; Hatem Hejaz; Bertrand Leblond; Matthew Paul Leese; Atul Purohit
Archive | 2010
Lok Wai Lawrence Woo; Toby Jackson; Christian Bubert; Atul Purohit; Michael John Reed; Barry Victory Lloyd Potter
Archive | 2007
Michael John Reed; Atul Purohit; Paul A. Foster; Simon P. Newman; Lok Wai Lawrence Woo; Barry Victor Lloyd Potter
Archive | 2006
Michael John Reed; Atul Purohit; Lok Wai Lawrence Woo; Barry Victor Lloyd Potter
Archive | 2002
Barry Victor Potter; Michael John Reed; Lok Wai Lawrence Woo
Archive | 2006
Lok Wai Lawrence Woo; Toby Jackson; Atul Purohit; Michael John Reed; Barry Victor Lloyd Potter