Lokesh Kumar Pandey

Hydrogen peroxide mediated efficient amidation and esterification of aldehydes: Scope and selectivity

An efficient method for the amidation and esterification of aldehydes utilizing hydrogen peroxide as an oxidant has been developed. Cyclic amines and primary alcohols selectively reacted with aromatic aldehydes under mild conditions to yield the corresponding amides and esters.

Expeditious Microwave-Assisted Thionation with the System PSCl3/H2O/Et3N under Solvent-Free Condition

A novel thionation protocol for carbonyl compounds, with the system PSCl3/H2O/Et3N has been discovered. Clean, rapid, and efficient synthesis of a variety of thiocarbonyl compounds such as thioamides, thiolactams, thioketones, thioxanthones, and thioacridone can be achieved through this simple and convenient method under solventless condition with microwave irradiation.

Silica–PSCl3: A Mild and Efficient Reagent for Deoxygenation of Sulfoxides

Abstract A new solid supported reagent, silica–PSCl3, has been developed for deoxygenation of sulfoxides. With this reagent, conversion of sulfoxides to sulfides occurred cleanly and efficiently at room temperature. Facile isolation of the product was achieved by simple filtration of the by‐products without any extensive workup.

Efficient and Convenient Oxidation of Thiols to Symmetrical Disulfide with Silica–PCl5/NaNO2 in Water

Abstract A very simple, environmentally benign, cost-effective, and efficient synthesis of disulfides from thiols using silica–PCl5/NaNO2 in aqueous medium has been described. The reaction was found to occur rapidly under mild conditions, and disulfides were obtained easily through a simple workup.

An easy access to tertiary amides from aldehydes and N,N-dialkylchlorothiophosphoramidates

A mechanistically unprecedented approach for the formation of tertiary amides from N,N-dialkylchlorothiophosphoramidates and aldehydes has been developed. The reaction occurred via the activation of aldehydes with N,N-dialkylchlorothiophosphoramidates followed by amidation with dialkylamine pendent of the same phosphoramidate.

Easy access to thiazolines and thiazines via tandem S-alkylation-cyclodeamination of thioamides/haloamines†

This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

Silica-PCL5: An Efficient and Reusable Catalyst for Cyclodehydration of 1, 3-Diketones to Flavones

Silica-PCl5 was employed as efficient solid acid catalyst for conversion of 1, 3-diketones to flavones under solventfree condition. Reaction is simple, efficient with easy work up and the catalyst is recyclable.

A SIMPLE AND EFFICIENT MICROWAVE MEDIATED SYNTHESIS OF NOVEL S- HETEROCYCLIC AMINOALKYLAMINO ETHNANE THIOLS

A very simple, efficient, microwave assisted synthesis for novel unsymmetrical thioethers with heterocyclic moieties under solvent free condition on solid support is described. This approach is convenient, straightforward, expeditious and environmentally benign.