Long-Wu Ye

Alkynes as equivalents of alpha-diazo ketones in generating alpha-oxo metal carbenes: a gold-catalyzed expedient synthesis of dihydrofuran-3-ones.

An expedient and reliable method for accessing reactive alpha-oxo gold carbenes via gold-catalyzed intermolecular oxidation of terminal alkynes has been developed. Significantly, this method offers a safe and economical alternative to the strategies based on diazo substrates. Its synthetic potential is demonstrated by expedient preparation of dihydrofuran-3-ones containing a broad range of functional groups.

Experimental and Computational Evidence for Gold Vinylidenes: Generation from Terminal Alkynes via a Bifurcation Pathway and Facile C-H Insertions

Facile cycloisomerization of (2-ethynylphenyl)alkynes is proposed to be promoted synergistically by two molecules of BrettPhosAuNTf(2), affording tricyclic indenes in mostly good yields. A gold vinylidene is most likely generated as one of the reaction intermediates on the basis of both mechanistic studies and theoretical calculations. Different from the well-known Rh, Ru, and W counterparts, this novel gold species is highly reactive and undergoes facile intramolecular C(sp(3))-H insertions as well as O-H and N-H insertions. The formation step for the gold vinylidene is predicted theoretically to be complex with a bifurcated reaction pathway. A pyridine N-oxide acts as a weak base to facilitate the formation of an alkynylgold intermediate, and the bulky BrettPhos ligand in the gold catalyst likely plays a role in sterically steering the reaction toward formation of the gold vinylidene.

A Flexible and Stereoselective Synthesis of Azetidin-3-Ones through Gold-Catalyzed Intermolecular Oxidation of Alkynes

Azetidine is a strained 4-membered nitrogen heterocycle and can be found in various natural products[1] and compounds of biological importance. While β-lactams, i.e., azetidin-2-ones, are a rich source of antibiotics,[2] their structural isomer, azetidin-3-ones, with the carbonyl group one-carbon removed from the nitrogen atom, have not been found in nature but could serve as versatile substrates for the synthesis of functionalized azetidines.[3]

Umpolung Reactivity of Indole through Gold Catalysis

The indole 3-position is highly electron-rich and typically functions as the primary nucleophilic site to react with a large array of electrophiles, leading to various functionalized indoles.[1] The reversal of this prime reactivity, i.e., making the indole 3-position electrophilic, would be of significant synthetic utility and provide a complementary strategy to access derivatives[2] otherwise difficult to prepare conventionally. This reactivity umpolung[3] of indole has, however, only been realized in limited cases.[4] For the past few years we have engaged in extensive studies of gold-catalyzed intra-[5] and intermolecular[6] alkyne oxidations using oxygen-delivering oxidants,[7] where reactive α-oxo gold carbene intermediates are presumably generated[8] and responsible for the diverse reaction outcomes. Lately we extended this strategy to the use of nitrene precursors as oxidants, providing access to reactive α-imino gold carbenes (Scheme 1A);[9] however, the chemistry has so far been limited to ynamides,[10] which are activated alkynes. In our effort to expand the scope of this type of gold-catalyzed nitrene transfer,[11] we decided to use an azido group as a nitrene precursor, which was inspired by previous studies of gold-[12] and platinum-catalyzed[13] pyrrole synthesis. We reasoned that closely and rigidly positioned C-C triple bonds in ortho-azidoarylalkynes might facilitate an intramolecular nitrene transfer from the azido group to the C-C triple bond. Importantly, the thus-formed gold carbene B would serve as an electrophilic indole equivalent, as depicted in its resonance form C, therefore realizing reactivity umpolung of the indole 3-position (Scheme 1B).[14] Scheme 1 Gold-catalyzed nitrene transfer: realizing reactivity umpolung at the indole 3-position. We started by using ortho-azidophenylalkyne 1a as the substrate and anisole as the nucleophile, and the initial reaction was run in toluene using Ph3PAuNTf2[15] as the catalyst. To our delight, the desired indole regioisomers 2a and 2a’ were indeed formed (entry 1), confirming that the azido group could function as a nitrene precursor and a gold carbene of type B might be indeed formed; moreover, this proposed reactive intermediate seemingly reacted mainly via its cationic resonance form C[16] as no Buchner reaction,[17] i.e., the formation of cycloheptatriene products, which is characteristic of carbene chemistry, occurred. The regioselectivity on the anisole ring is consistent with an electrophilic aromatic substitution mechanism. To our surprise, the majority of the putative gold intermediate B/C reacted with the solvent toluene, yielding a mixture of regioisomers (p-3/o-3/m-3 = 41%/11%/8%). Although the concentration of toluene is ~190 time of that of anisole, anisole is much more nucleophilic than toluene.[18] These results indicate that intermediate C is strongly electrophilic and hence less selective. This conclusion is consistent with the ratio of p-3 vs. m-3 (~5), lower than that in the case of nitration (>10),[19] suggesting that C might be even more electrophilic than NO2+. Since products of type 2a, 2a’, and 3 are also good nucleophiles, we anticipated that it is essential to use excess intended nucleophiles in order to minimizing their competing reactions with highly electrophilic C. Other solvents were screened in order to minimize solvent participation (entries 2–4). While benzene also interfered the desired reaction (entry 2), neither DCE (entry 3) nor chlorobenzene (entry 4) did; a better reaction yield was realized in DCE. Examining different gold catalysts (entries 5–10) at a beneficiary higher reaction temperature (comparing entries 3 and 5) revealed that IPrAuNTf2 (entry 6) gave the best yield and bulky t-BuXPhosAuNTf2 gave the best para/ortho ratio (entry 8). We also run the reaction using anisole as the solvent at a higher concentration (0.2 M). Somewhat to our surprise, the reaction became dramatically faster and finished in 5 min at 80 °C; moreover, the yield was excellent. Perhaps even more surprising is that the para/ortho ratio decreased as the reaction temperature got lower (comparing entries 11–13). This may suggest the involvement of another reaction mechanism. As shown in Scheme 2, at a higher temperature (e.g., 80 °C), the formation of B/C should be facilitated, but at a lower temperature (e.g., −20 °C) its precursor, i.e. A, may persist and play an increasing role in the reaction by reacting with nucleophiles via an SN2’ process; since the Au-C bond length in B/C should be shorter than the Au-C bond in A, one might expect that the more the reaction goes through B/C the more regioselective as the bulky ligand (i.e., t- BuXPhos) can be more sterically imposing.[20] Scheme 2 Rationale for the inversed relationship between regioselectivities and reaction temperatures. The scope of o-azidoarylalkynes was subsequently examined by first varying the alkyne substituent. Using anisole as the solvent, primary alkyl groups such as n-butyl (Table 2, entry 1) and phenethyl (Table 2, entry 2) reacted smoothly; a lower yield was obtained with 1d containing a benzyl ether (Table 2, entry 3); cyclic secondary alkyl groups (Table 2, entries 4–6) as well as a tert-butyl group (Table 2, entry 7) all led to good yields; interestingly, substrate 1i with a terminal alkyne also worked (Table 2, entry 8); aryl groups with either a p-MeO (Table 2, entry 10) or a p-methoxycarbonyl group (Table 2, entry 11) were readily tolerated, and the corresponding indoles were formed in good to excellent yields. In all the cases, the regioselectivities correlated well with the substituent steric size, and the best 2/2’ ratio was realized with the tert-butyl alkyne 1h. In addition, substrates with substituted benzene ring also reacted with good efficiencies, thus offering highly substituted indole products (entries 11 and 12). Table 2 The scope of o-azidoarylalkyne substrates.[a] The applicability of this chemistry to other nucleophiles was then probed using the conditions in Table 1, Entry 6, and the successful examples are shown in Table 3. As expected, p-xylene, when used as solvent, served as a suitable nucleophile for this chemistry (entry 1). In the case of naphthalene, the α-position is preferred due to its stronger nucleophilicity (entry 2). More activated benzene rings (entries 3 and 4) gave good yields of desired products, and a good selectivity (10:1) was observed with 1,3-dimethoxybenzene, reflecting the more congested nature of the 2-position. In the case of N-methylpyrrole, apparently the electronic and the steric factors were working against each other; consequently, no regioselectivity was observed (entry 5); nevertheless, the overall efficiency was excellent. Increasing the steric hindrance at the pyrrole 2-position by installing a TIPS group on the ring nitrogen indeed made the reaction occurred selectively at the 3-position (entry 6). When N-benzylindole was used as the nucleophile, to our surprise, at least three inseparable regioisomers were formed, suggesting that its benzene ring participated in this reaction as the nucleophilic site. To our delight, with strongly electron-withdrawing nitro group on the indole benzene ring, the substitution selectively occurred on the 3-position, affording nonsymmetrical 3,3’-biindoles with good yields (entries 7 and 8). The use of the more polar azidoalkyne substrate 1k facilitated purification of the products. With the indole 2-position substituted and its benzene ring again deactivated, the electrophilic substitution proceeded expectedly at the 3-position to yield hindered biindole 5i. Notably, the 3,3-biindole structure has been found in natural products[21] and compounds of medical interest,[22] and their syntheses often require multiple steps.[23] Dimedone methyl ether could react as a nucleophile as well albeit accompanied with in-situ hydrolysis and in a relatively low reaction yield (entry 10). Besides carbon nucleophiles, alcohols could react with intermediates of type C (entries 11 and 12). The moderate yields were to some extent due to (1) (2) the susceptibility of the products towards aerobic oxidation. Interestingly, with allyl alcohol as the nucleophile, the product underwent one-pot Claisen rearrangement, yielding indol-3-one 5m in a serviceable yield (entry 13). Notably, no desired product was observed when using N-methyltosylamide as the nucleophile. Table 1 Initial discovery and condition optimizations.[a] Table 3 The scope of different nucleophiles.[a] This reactivity umpolung of indole was briefly tested in intramolecular scenarios. With azidoalkyne 1c, in the absence of an external nucleophile such as anisole (e.g., in Table 2, entry 2), the tethered benzene ring reacted as the nucleophile, efficiently trapping the electrophilic indole 3-position and thereby forming tetracyclic product 6 in a good yield (Eq. 1). To our surprise, even a seven-membered ring could be readily formed via this intramolecular trapping (Eq. 2); moreover, this reaction appeared to be rather facile as the tetracyclic product 7 was formed in ca. 4% yield even when anisole was used as the solvent (Table 2, entry 3), again implicating the high electrophilicity of the intermediate B/C. In summary, we have developed a new approach to achieving reactivity umpolung of indole at the 3-position via gold catalysis. By using an ortho-azido group to deliver a nitrene intramolecularly, an arylalkyne can be converted into a gold carbene intermediate that contains the indole skeleton but highly electrophilic at the 3-position. The reaction of this electrophilic indole intermediate with variously nucleophiles provides a novel and expedient synthesis of a range of functional indoles.

Generation of α-Imino Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

The generation of α-imino gold carbenes via gold-catalyzed intermolecular reaction of azides and ynamides is disclosed. This new methodology allows for highly regioselective access to valuable 2-aminoindoles and 3-amino-β-carbolines in generally good to excellent yields. A mechanistic rationale for this tandem reaction, especially for the observed high regioselectivity, is supported by DFT calculations.

Generation of gold carbenes in water: efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines

The efficient intermolecular reaction of gold carbene intermediates, generated via gold-catalyzed alkyne oxidation, with indoles and anilines has been realized in aqueous media. Importantly, it was revealed for the first time that water could dramatically suppress the undesired over-oxidation, providing a general and practical solution to the problem of over-oxidation in gold-catalyzed intermolecular alkyne oxidation with external nucleophiles. This strategy was successfully applied to the formal synthesis of the Pfizers chiral endothelin antagonist UK-350,926.

Tandem Michael addition/ylide epoxidation for the synthesis of highly functionalized cyclohexadiene epoxide derivatives

A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.

Zinc‐Catalyzed Alkyne Oxidation/CH Functionalization: Highly Site‐Selective Synthesis of Versatile Isoquinolones and β‐Carbolines

An efficient zinc(II)-catalyzed alkyne oxidation/C-H functionalization sequence was developed, thus leading to highly site-selective synthesis of a variety of isoquinolones and β-carbolines. Importantly, in contrast to the well-established gold-catalyzed intermolecular alkyne oxidation, over-oxidation can be completely suppressed in this system and the reaction most likely proceeds by a Friedel-Crafts-type pathway. Mechanistic studies and theoretical calculations are described.

Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes

The first gold-catalyzed addition of N-arylhydroxylamines to aliphatic terminal alkynes is developed to access O-alkenyl-N-arylhydroxylamines, which undergo facile in situ sequential 3,3-rearrangements and cyclodehydrations to afford 2-alkylindoles with regiospecificity and under exceptionally mild reaction conditions.

Gold-Catalyzed Oxidative Cyclization of Chiral Homopropargyl Amides: Synthesis of Enantioenriched γ-Lactams

A gold-catalyzed tandem cycloisomerization/oxidation of homopropargyl amides has been developed, which provides ready access to synthetically useful chiral γ-lactams with excellent ee by combining the chiral tert-butylsulfinimine chemistry and gold catalysis. The utility of this methodology has also been demonstrated in the synthesis of biologically active compound S-MPP and natural product (-)-bgugaine. The use of readily available starting materials, a simple procedure, and mild reaction conditions are other significant features of this method.