Lorena Gabriela Rocha Ribeiro

Caracterização clínica, diagnóstico histopatológico e distribuição geográfica das neoplasias mamárias em cadelas de Salvador, Bahia

Os tumores espontâneos da glândula mamaria representam, nas cadelas, a neoplasia mais observada na clinica de pequenos animais, justificando o grande interesse dos pesquisadores no estudo dessa lesao. Este trabalho teve por objetivo determinar a frequencia dos tumores mamarios em cadelas atendidas no HOSPMEV/UFBA, no municipio de Salvador, no periodo de janeiro de 2006 a abril de 2008, bem como realizar a caracterizacao clinica, a classificacao histopatologica e o georreferenciamento dessa patologia. Os resultados revelaram alta prevalencia de neoplasias mamarias em cadelas, em sua maioria tumores, em estadios mais avancados, sendo os carcinomas em tumores mistos o tipo histologico predominante. Observou-se ainda a correlacao das caracteristicas socioeconomicas da populacao estudada com fatores sabidamente prognosticos para neoplasias mamarias em cadelas. Esses resultados refletem a procura tardia da assistencia Medica Veterinaria. Por isso, e ur gente educar a populacao quanto a prevencao e deteccao da neoplasia mamaria nas cadelas, buscando o diagnostico precoce e a terapeutica adequada. Palavras-chave: tumor de mama, estadiamento clinico, fatores socioeconomicos.

Versican expression in myoepithelial cells from carcinomas in canine mixed mammary tumors

The matrix of canine mixed mammary tumors (CMMTs) consists of proliferating spindle cells of possible myoepithelial origin, as well as myxomatous tissue, cartilage matrix and/or bone. Among the multiple components of this tumor extracellular matrix, versican probably plays a prominent role due to its importance in tumor progression, cell proliferation and differentiation. However, there are few data related to a possible association between versican expression and the state of myoepithelial cell differentiation in CMMTs. Using immunohistochemistry and histochemistry, the objective of this study was to evaluate the expression of versican, sulfated proteoglycans and mucopolysaccharides in myoepithelial cells at different stages of differentiation and to explore a potential relationship with p63 and α-smooth muscle actin (SMA) expression. A significant difference in versican expression was observed among the different stages of myoepithelial cell differentiation with an inverse correlation between versican and p63/SMA expression. These results suggest that at an early stage of proliferation, myoepithelial cells acquire a phenotype consistent with a role in chondrogenesis. Moreover, myoepithelial cells showed an affinity for safranin and periodic acid-Schiff staining at different stages of proliferation supporting the myoepithelial origin of spindle cells from CMMTs.

Detecção de aglomerados espaciais de casos de neoplasia mamária em cães no município de Salvador, Bahia

Spontaneous mammary tumors represent the most frequent type of cancer in canines, accounting for approximately 50% of all neoplasms. The majority of scientific papers cited in the literature are limited to non refined epidemiological data, without mentioning the trend of this disease in generating clusters in a given geographical area. In this context, this research aimed to create thematic maps of spatial distribution of mammary neoplasms in bitches and to identify disease clusters for the city of Salvador, Bahia. Trough the spatial analysis scanning, it was found that cases of breast cancer is not evenly distributed in the municipality. A significant primary cluster was detected (P>0,001) covering 67.3% of the studied cases. Considering the gap in literature available in this field, it is believed that such results will become very important, especially in leading to new studies, where intrinsic and extrinsic variables regarding the animal must be taken into consideration and analyzed for factors risk identification to formulate educational plans targeting the promotion of animal welfare.