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Dive into the research topics where Lorenza Perversi is active.

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Featured researches published by Lorenza Perversi.


Journal of Chemotherapy | 2001

Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori.

Piero Marone; Letizia Bono; Eugenio Leone; S. Bona; Edoardo Carretto; Lorenza Perversi

Abstract In this study we evaluated the antibacterial activity of mastic gum, a resin obtained from the Pistacia lentiscus tree, against clinical isolates of Helicobacter pylori. The minimal bactericidal concentrations (MBCs) were obtained by a microdilution assay. Mastic gum killed 50% of the strains tested at a concentration of 125 μg/ml and 90% at a concentration of 500 μg/ml. The influence of sub-MBCs of mastic gum on the morphologies of H. pylori was evaluated by transmission electron microscopy. The lentiscus resin induced blebbing, morphological abnormalities and cellular fragmentation in H. pylori cells.


Fems Immunology and Medical Microbiology | 1996

In vitro and in vivo induction of nitric oxide by murine macrophages stimulated with Bordetella pertussis

Donato Torre; Giulio Ferrario; Giancarla Bonetta; Lorenza Perversi; Filippo Speranza

Nitric oxide (NO) exhibits potent antimicrobial activity in vitro. The function of NO in host defenses in vivo, however, is presently unclear. Experiments were undertaken to determine the production of NO in vitro from murine peritoneal and alveolar macrophages, and murine macrophage cell line (J774A.1) stimulated with Bordetella pertussis or pertussis toxin (PT). In addition, we determined circulating levels of NO in the sera and bronchoalveolar lavage (BAL) fluids of mice infected intranasally with B. pertussis. The results of this study showed that in vitro murine peritoneal macrophages induce production of NO in response to B. pertussis and PT. In addition, murine macrophage cell line, J774A.1 also induces NO production after stimulation with B. pertussis. NO production was also detected in alveolar macrophages from mice infected intranasally with B. pertussis. Finally, a significant increment of circulating levels of NO was noted, in the sera but not in the BAL fluids, of mice infected intranasally with B. pertussis.


Ophthalmologica | 1995

Ocular Infections: Antibiotics and Bacterial Adhesion on Biomaterials Used in Ocular Surgery

Piero Marone; Lorenza Perversi; Vincenzina Monzillo; Renato Maserati; Elena Antoniazzi

The in vitro antibacterial activity of ofloxacin, sagamycin and other antibiotics was evaluated against 85 bacterial isolates [coagulase-negative staphylococci (CNS), n = 37, Staphylococcus aureus, n = 28, and Pseudomonas aeruginosa, n = 20] obtained from patients with ocular infections. The antistaphylococcal activity of ofloxacin was quite elevated with a 90% minimal inhibitory concentration (MIC90) of 1.56 mg/l against CNS and S. aureus. Rokitamycin and erythromycin showed a good activity against methicillin-sensitive staphylococci, but were less active than ofloxacin and sagamycin against methicillin-resistant strains (MIC90 > 100 mg/l). Sagamycin was highly effective against staphylococci (MIC90 0.78 mg/l) and appeared to be the most active compound against P. aeruginosa (MIC90 6.25 mg/l), followed by ofloxacin, tobramycin and gentamicin. In a successive part of the study, the adhesive properties of slime-producing staphylococci were tested on biomaterials used in ocular surgery. Intraocular lenses, Silastic sheetings, circling bands and grooved strips showed a high affinity for slime-producing strains, while round silicone sponges were not covered by bacterial biofilm. In the last part of our study, we demonstrated how subMIC levels of ofloxacin increased the adhesion of slime-producing staphylococci. Our data confirmed the excellent activity of ofloxacin and sagamycin against ocular pathogens and the key role of adhesion in promoting colonization and infections of biomaterials.


Journal of Chemotherapy | 1993

Activity of Daptomycin against Enterococci and Coagulase-Negative Staphylococci (CNS): Relationship between CNS Susceptibility and Slime Production

Piero Marone; Lorenza Perversi; A. Navarra; V. Monzillo; E. Sartirana

We compared the in vitro activity of daptomycin, a new lipopeptide antibiotic, with that of vancomycin and other selected agents against 95 coagulase negative staphylococci (CNS) isolates causing septicemia or foreign-body infections in immunocompromised patients. These strains were classified as follows: 51 methicillin-susceptible CNS (23 slime producers); 44 methicillin-resistant CNS (23 slime producers). We also investigated the activity of daptomycin against 50 Enterococcus faecalis isolates. Minimal inhibitory concentrations (MICs) were determined by the broth microdilution method. Daptomycin at a concentration of 2 mg/L was inhibitory for all the evaluated strains. Vancomycin and ciprofloxacin showed good activity: 90% of the strains were inhibited by these agents at 8 mg/L. The activity of netilmicin, rifampin and trimethoprim-sulfamethoxazole was instead limited. Resistance to the antimicrobial agents tested was seen with increased frequency among slime producing strains. Daptomycin and teicoplanin were the most active agents tested against E. faecalis (MIC90 0.25 mg/L and 0.12 mg/L).


Journal of Chemotherapy | 1998

Comparative in vitro activity of silver sulfadiazine, alone and in combination with cerium nitrate, against staphylococci and gram-negative bacteria

Piero Marone; V. Monzillo; Lorenza Perversi; E. Carretto


The Journal of Infectious Diseases | 1993

Interferon-γ Levels in Serum and Bronchoalveolar Lavage Fluid of Mice Infected with Bordetella pertussis

Donato Torre; Agostino Pugliese; Filippo Speranza; Giovanni Paolo Fiori; Lorenza Perversi; Piero Marone; Roberto Tambini


Haematologica | 2000

Vancomycin-resistant Enterococcus faecium infection in three children given allogeneic hematopoietic stem cell transplantation: clinical and microbiologic features

Edoardo Carretto; Daniela Barbarini; Franco Locatelli; Eugenia Giraldi; Nicoletta Pellegrini; Lorenza Perversi; Paolo Grossi; Piero Marone; Federico Bonetti


Fems Immunology and Medical Microbiology | 1994

Effects of recombinant human gamma interferon on intracellular survival of Bordetella pertussis in human phagocytic cells

Donato Torre; Giulio Ferrario; Giancarla Bonetta; Lorenza Perversi; Roberto Tambini; Filippo Speranza


The Journal of Infectious Diseases | 1996

Effects of Recombinant Murine (rm) Interleukin-12 and rm Interferon-γ in Mice Infected with Bordetella pertussis

Donato Torre; Filippo Speranza; Agostino Pugliese; Lorenza Perversi; Piero Marone; Giulio Ferrario


Ophthalmologica | 1995

Contents, Vol. 205, 1995

Kano Hiroi; Mutsuko Miyake; Tadashi Hashimoto; Yoshihito Honda; Hedwig J. Kaiser; Josef Flammer; Daniela Stümpfig; Phillip Hendrickson; F. Devin; T. Jourdan; Piero Marone; Lorenza Perversi; Vincenzina Monzillo; Renato Maserati; Elena Antoniazzi; Sang Y. Lee; Oh Woong Kwon; Young Jae Hong; Hong B. Kim; Sung J. Kim; F. Daxecker; M. Blumthaler; W. Ambach; Kenji Matsuo; Kazuo Nakatuka; Toshie Matsuura; Shigeo Yokoyama; Nihal Demircan; Sait Polat; Gülhanim Haciyakupoǧlu

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