Louis Burke

Carcinoma of the cervix in Jewish women

Abstract 1. 1. Of 323 patients with carcinoma of the cervix seen at the Mount Sinai Hospital, New York, from 1928 to 1948, there were 80 Jewish women. Eight of these patients had carcinoma of the cervical stump following subtotal hysterectomy. 2. 2. Carcinoma of the cervix in Jewish women, although not common, is not a rare lesion. Carcinoma of the cervix occurs about five times as frequently in the non-Jewish as in the Jewish woman.

Villous adenoma presenting as a vaginal polyp in a rectovaginal tract

A 72-year-old woman had a villous adenoma of endodermal derivation involving the rectovaginal septum and contiguous mucosal surfaces that presented clinically as a vaginal polypoid tumor. To explain the vaginal involvement, we postulate that the adenoma traversed a tract of developmental origin within the rectovaginal septum. This is the first report of such a unique constellation of findings.

VAGINAL ADENOSIS. FACTORS INFLUENCING DETECTION IN A COLPOSCOPIC EVALUATION

In a colposcopic evaluation of DES-related genital abnormalities, biopsy-proven adenosis was detected in the vaginal nails or hood in 84.5% of 220 women. Patient selection (DES history only vs prior examination) did not significantly influence the detection rale for adenosis. However, the detection rate of adenosis in the vaginal walls showed highly significant correlations with the presence of cervical cetopy and/or hood and with the colposcopic appearance of the area biopsied. Using colposcopy, the columnar pattern had a diagnostic accuracy of 94.4%; mosaic pattern, 85.5%; and white appearance, 68.0%. Differences in the histologic features of mucosal surface glandular tissue, squamous metaplasia, and nonglycogenated squamous mucosa were related to specific colposcopic patterns and helped to account for the variation in the accuracy of the three appearances in detecting adenosis. Biopsy specimens of the hood were not necessary to achieve a high yield of adenosis although we obtained evidence that the hood contains microscopic features typical of vaginal adenosis. Epithelial atypicality in the vagina (moderate squamous cell dysplasia) was demonstrated in only 1 patient.