Louis M. Abbey

Comparison between the peripheral ossifying fibroma and peripheral odontogenic fibroma

This study presents previously unreported data on a series of 400 peripheral ossifying fibromas (POFs) and 13 peripheral odontogenic fibromas (PODFs). The differences between the two lesions are discussed, and comparisons are made with other reports in the literature. It is concluded that the lesions represent separate pathologic entities.

Actinic cheilitis: A review of 152 cases ☆ ☆☆

OBJECTIVE The purpose of this study was to determine whether any clinical or histopathologic variables are associated with the severity of epithelial change in lesions of actinic cheilitis. STUDY DESIGN A total of 152 acceptable cases of actinic cheilitis were identified from 66,067 cases accessioned from February 1989 to June 1998. For each case, the clinical information supplied by the submitting practitioner at the time of the biopsy and 8 histopathologic variables were evaluated. RESULTS The following 5 histopathologic variables were positively correlated with an increased degree of epithelial change: acanthosis, basophilic change within the connective tissue, the presence of inflammation within the connective tissue, perivascular inflammation, and thickness of the keratin layer. None of the clinical variables was associated with an increased degree of epithelial change. CONCLUSIONS The presence of any of the aforementioned histopathologic changes should prompt a close evaluation of the lesion for the presence of either epithelial dysplasia or carcinoma.

The clinical and histopathologic features of a series of 464 oral squamous cell papillomas

A clinical and histopathologic analysis of 464 oral squamous cell papillomas is presented. Data on age, sex, race, location, clinical appearance, duration, recurrence, and clinical diagnosis are reviewed. One hundred seventy-six of the 464 specimens were examined for hyperkeratosis, character and amount of inflammatory infiltrate, and evidence of cellular atypia. The trends seen in this study support claims made by previous authors regarding incidence and inflammatory involvement. The data support a slightly higher occurrence rate in males than in females and in white as opposed to black patients. Papillomas were most abundant on the palatal complex, dorsum and lateral tongue borders, and lower lips, respectively. Confusion of papilloma for fibroma in the clinical diagnosis was less common than expected. Recurrence rate and incidence of multiple papillomas were low. Histologic study revealed a tendency for hyperkeratotic lesions to arise from nonkeratinized oral sites. Cellular atypia was found, but it is still unclear whether these changes are preneoplastic or due to an increased growth rate.

Oral melanotic macules. A review of 353 cases.

Clinical and histopathologic data were obtained on 353 cases of oral melanotic macules. The mean age at the time of diagnosis for all sites was 43.1 years. A significant predilection for females (p < 0.001) was noted and the most common location was the lower lip (33.0%). The mean size of the lesions was 6.8 mm. Brown was the most common color (64.9%), and most (66.0%) of the lesions were described as flat. Melanin was evident in both the basal cell layer and lamina propria in 93.5% of the cases.

Solitary intraductal papilloma of the minor salivary glands

A case of solitary intraductal papilloma of a minor salivary gland is presented. The lesion was diagnosed clinically as a mucocele and has not recurred in 6 months of observation. This case is compared, on the basis of clinical data and histomorphologic findings, to three other known cases. Discussion is made of the role this lesion might play in the etiology of ductal obstruction, and the histologic findings of the intraductal papilloma of minor salivary glands and the solitary intraductal papilloma of the breast are compared.

Incidence of second primary breast cancer among patients with a first primary salivary gland tumor

A survey was conducted through the Virginia Tumor Registry to ascertain whether there was a higher‐than‐expected rate of second primary breast cancers among women having a first primary tumor (benign or malignant) of the salivary glands. The population included 372 patients (182 men and 190 women) diagnosed between January 1, 1960 and December 31, 1979. Second primary breast cancer occurrence among women in this group was 4.8 times the expected number (P = 0.0102). Ages of those developing a second primary fell between 37 and 79 years. No racial prevalence was observed. The time of diagnosis of the first and second primary tumors was more than 6 years in 75% of the cases. It was concluded that women in our population incurred a fourfold‐to‐fivefold increased risk of a second primary breast cancer subsequent to the first primary salivary gland tumor. Consideration of this observation should be in the minds of clinicians seeing patients for follow‐up.

Focal oral warty dyskeratoma.

ABSTRACT: A 49‐year‐old white man developed focal oral warty dyskeratoma, which is a solitary, elevated nodule with a keratotic umbilicated center. The term “focal oral warty dyskeratoma” was suggested to distinguish these lesions from the histologically similar oral lesions found in Dariers disease. This paper reviews previously published reports of the lesion and presents an additional case. The average age of patients was 52.2 years, and a slight male predilection was noted. In almost all cases, the lesion was found in tissue overlying bone, with the maxillary alveolar ridge and palate being the most common locations. When the side of involvement was given, all lesions were noted to be on the left side. No evidence of a viral presence was seen with light or electron microscopic study, but the possibility of chronic irritation, such as tobacco usage, exists as an etiologic agent.

Prolactin binding in minor salivary gland tumors

An immunohistochemical study of 15 minor salivary gland tumors was initiated to determine if prolactin binding occurred in these tissues. Eight benign mixed tumors (BMT) and 7 adenoid cystic carcinomas (ACC) were selected at random from the surgical biopsy service of the MCV/VCU School of Dentistry, Department of Oral Pathology. The specimens were cut and mounted on slides along with sections of rat pituitary and rat ventral prostate which served as methodologic controls. Experimental specimens were incubated for 24 hours with varying concentrations of highly purified (iodination grade) rat prolactin; controls were incubated with vehicle. Following incubation the specimens were stained according to the Sternberger peroxidase-antiperoxidase method. Results showed dose-dependent staining for prolactin binding sites in 7 of 8 BMTs and 5 of 7 ACCs. The staining was wider in distribution than we observed in normal human minor salivary gland tissue. Binding was confined primarily to cells of duct origin in both types of tumor. In individual cells, staining was observed in diffuse cytoplasmic and perinuclear locations as well as in nuclei and apical regions. We conclude that two minor salivary gland neoplasms (BMT and ACC) exhibit prolactin binding at different cellular locations and in a more widespread pattern than was observed in normal minor salivary gland.

Prolactin binding in normal human minor salivary gland tissue: an immunohistochemical study

The breast and salivary gland exhibit some similarities in the biochemical and cellular spheres. There are also some tumors that are common to both organs. The protein hormone prolactin seems to play a role in the health and disease of the mammary gland, and an investigation was launched to see if this hormone exhibited any binding activity in normal human minor salivary gland. With the use of immunohistochemical methods, dose-dependent staining for prolactin binding was demonstrated in the striated and collecting ducts in four of six specimens of normal human minor salivary gland (two males and two females). The hormone concentrations used ranged from 6.25 ng/ml to 500 ng/ml of highly purified rat prolactin. A review of known functions of prolactin in man and other animals is presented, and it was concluded that normal human minor salivary gland tissue possesses binding sites for prolactin, which suggests that prolactin may play a role in the metabolic functioning of the salivary duct cells.

Oral squamous acanthoma. Two additional cases with comments on etiology.

Two new cases of squamous acanthoma are presented, and the their clinical characteristics are compared to the eight cases previously reported. These two additional examples of this lesion are clinically similar to those previously reported. However, one of the two cases exhibits resolution after the removal of sources of trauma, thus lending support to the previously proposed theory of traumatic etiology.