Louis Pichat

(E)-alcenyl-5 desoxy-2′ uridines par couplages d'organozirconiens ethyleniques avec l'iodo-5 o-3′,5′-bis (trimethyl) desoxyuridine, catalyses par des complexes organopallades

Abstract (E) 5-Alkenyl 2′-deoxyuridines are obtained with moderate to high yields by the palladium catalyzed reaction of alkenylzirconium reagents with O-3′,5′-bis(trimethylsilyl) deoxyuridine in T.H.F.

Synthese de nucleosides substitues en C-5 par un carbocycle ou un heterocycle par couplages D′organozinciques avec L′iodo-5 O-bis(trimethylsilyl)-3′,5′ desoxy-2′ uridine catalyses par des complexes organopalladies.

Abstract Some nucleosides, substituted at C-5 by a carbocycle or an heterocycle, were obtained in low yields by the palladium-catalyzed reaction of organozine reagents with 0–3′,5′ his (trimethylsilyl)-2′-desoxyuridine.

Alcynyl-5 desoxy-2′ uridines par couplages d'organozinciques acetyleniques avec l'iodo-s 0-3′, 5′-bis(trimethylsilyl) desoxyuridine, catalyses par des complexes organopalladies et de nickel

Abstract 5-Alkynyl 2′-deoxyuridines are obtained in low to modest yields by the palladium and Nickel catalyzed reaction of alkynylzinc reagents with 0-3′, 5′-bis(trimethylsilyl) deoxyuridine in T.H.F.

Modifications de la position C-8 de purines nucleosides par action de reactifs electrophiles sur leurs derives silyles et lithies

Abstract The alkylation of 8-lithiopurine trimethylsilyl nucleosides at carbon 8 can be carried out conveniently by reaction with various electrophilic reagents.

Modification de la position 8 des purines nucleosides et de l'adenosine monophosphate cyclique-3′,5′. Reactions de couplage catalytique des organo-magnesiens avec les bromo-8 purines ribosides et bromo-8 adenosine monophosphate cyclique-3′,5′ silyles en presence de dichloro-bis-triphenylphosphine palladium

Abstract The palladium catalysed condensation of Grignard reagents with silyl derivatives of 8-bromopurine nucleosides and 8-bromoadenosine-3′,5′ cyclic monophosphate is a convenient method for the preparation of free 8-alkylpurine nucleosides and 8-alkyladenosine-3′,5′ cyclic monophosphate.