Louis-Pierre Molleyres
Syngenta
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Publication
Featured researches published by Louis-Pierre Molleyres.
PLOS ONE | 2012
Ann E. Sluder; Sheetal Shah; Jérôme Yves Cassayre; Ralph Clover; Peter Maienfisch; Louis-Pierre Molleyres; Elizabeth A. Hirst; Anthony J. Flemming; Min Shi; Penny Cutler; Carole Stanger; Richard Spurring Roberts; David Hughes; Thomas Flury; Mike Robinson; Elke Maria Hillesheim; Thomas Pitterna; Fredrik Cederbaum; Paul Anthony Worthington; Andrew J. Crossthwaite; John Windass; Richard A. Currie; Fergus Gerard Paul Earley
The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at novel protein binding sites is therefore important for the continued protection of the food supply from insect predators, and of human and animal health from insect borne disease. Here we describe a novel class of insecticides (Spiroindolines) encompassing molecules that combine excellent activity against major agricultural pest species with low mammalian toxicity. We confidently assign the vesicular acetylcholine transporter as the molecular target of Spiroindolines through the combination of molecular genetics in model organisms with a pharmacological approach in insect tissues. The vesicular acetylcholine transporter can now be added to the list of validated insecticide targets in the acetylcholine signalling pathway and we anticipate that this will lead to the discovery of novel molecules useful in sustaining agriculture. In addition to their potential as insecticides and nematocides, Spiroindolines represent the only other class of chemical ligands for the vesicular acetylcholine transporter since those based on the discovery of vesamicol over 40 years ago, and as such, have potential to provide more selective tools for PET imaging in the diagnosis of neurodegenerative disease. They also provide novel biochemical tools for studies of the function of this protein family.
Archive | 2005
Peter Maienfisch; Louis-Pierre Molleyres; Jérôme Yves Cassayre; Fredrik Cederbaum; Camilla Corsi; Thomas Pitterna
Archive | 2003
Jill Patricia Benner; Bettina Gertrud Henriette Boehlendorf; Martin Richard Kipps; Nicolas Eugene Paul Lambert; Riet Luck; Louis-Pierre Molleyres; Snezana Neff; Traugott Christoph Schuez; Paul David Stanley
Archive | 2005
Jérôme Yves Cassayre; Peter Maienfisch; Fredrik Cederbaum; Louis-Pierre Molleyres; Camilla Corsi; Thomas Pitterna
Archive | 2004
Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch; Fredrik Cederbaum
Archive | 2004
Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch; Fredrik Cederbaum
Archive | 2004
Louis-Pierre Molleyres; Jérôme Yves Cassayre; Fredrik Cederbaum; Peter Maienfisch
Archive | 2004
Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch; Fredrik Cederbaum
Archive | 2013
Peter Maienfisch; Louis-Pierre Molleyres; Jérôme Yves Cassayre; Fredik Cederbaum; Camilla Corsi; Thomas Pitterna
Archive | 2007
Thomas Pitterna; Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch