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Dive into the research topics where Louis-Pierre Molleyres is active.

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Featured researches published by Louis-Pierre Molleyres.


PLOS ONE | 2012

Spiroindolines identify the vesicular acetylcholine transporter as a novel target for insecticide action.

Ann E. Sluder; Sheetal Shah; Jérôme Yves Cassayre; Ralph Clover; Peter Maienfisch; Louis-Pierre Molleyres; Elizabeth A. Hirst; Anthony J. Flemming; Min Shi; Penny Cutler; Carole Stanger; Richard Spurring Roberts; David Hughes; Thomas Flury; Mike Robinson; Elke Maria Hillesheim; Thomas Pitterna; Fredrik Cederbaum; Paul Anthony Worthington; Andrew J. Crossthwaite; John Windass; Richard A. Currie; Fergus Gerard Paul Earley

The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at novel protein binding sites is therefore important for the continued protection of the food supply from insect predators, and of human and animal health from insect borne disease. Here we describe a novel class of insecticides (Spiroindolines) encompassing molecules that combine excellent activity against major agricultural pest species with low mammalian toxicity. We confidently assign the vesicular acetylcholine transporter as the molecular target of Spiroindolines through the combination of molecular genetics in model organisms with a pharmacological approach in insect tissues. The vesicular acetylcholine transporter can now be added to the list of validated insecticide targets in the acetylcholine signalling pathway and we anticipate that this will lead to the discovery of novel molecules useful in sustaining agriculture. In addition to their potential as insecticides and nematocides, Spiroindolines represent the only other class of chemical ligands for the vesicular acetylcholine transporter since those based on the discovery of vesamicol over 40 years ago, and as such, have potential to provide more selective tools for PET imaging in the diagnosis of neurodegenerative disease. They also provide novel biochemical tools for studies of the function of this protein family.


Archive | 2005

Piperidine derivatives and their use as insecticides, acaricides, molluscicides or nematicides

Peter Maienfisch; Louis-Pierre Molleyres; Jérôme Yves Cassayre; Fredrik Cederbaum; Camilla Corsi; Thomas Pitterna


Archive | 2003

Biocidal compounds and their preparation

Jill Patricia Benner; Bettina Gertrud Henriette Boehlendorf; Martin Richard Kipps; Nicolas Eugene Paul Lambert; Riet Luck; Louis-Pierre Molleyres; Snezana Neff; Traugott Christoph Schuez; Paul David Stanley


Archive | 2005

Piperazine Derivatives and Their Use in Controlling Pests

Jérôme Yves Cassayre; Peter Maienfisch; Fredrik Cederbaum; Louis-Pierre Molleyres; Camilla Corsi; Thomas Pitterna


Archive | 2004

Spiroindoline derivatives having insecticidal properties

Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch; Fredrik Cederbaum


Archive | 2004

Use of (3-(1-(3-phenyl-propenyl)-piperidin-4-yl)-2,3-dihydro-indol-1-yl)-(pyridin-4-yl)-methanone derivatives and related compounds as insecticides

Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch; Fredrik Cederbaum


Archive | 2004

Spiropiperidine derivatives for controlling pests

Louis-Pierre Molleyres; Jérôme Yves Cassayre; Fredrik Cederbaum; Peter Maienfisch


Archive | 2004

Spiro-condensed indoline derivatives as pesticides

Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch; Fredrik Cederbaum


Archive | 2013

Piperidine derivatives with pesticidal properties

Peter Maienfisch; Louis-Pierre Molleyres; Jérôme Yves Cassayre; Fredik Cederbaum; Camilla Corsi; Thomas Pitterna


Archive | 2007

Diaza-spiro [4 . 5] decanes useful as pesticides

Thomas Pitterna; Jérôme Yves Cassayre; Louis-Pierre Molleyres; Peter Maienfisch

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