Louise Jensen

Qualitative Metasynthesis: Reflections on Methodological Orientation and Ideological Agenda:

In an era of pressure toward evidence-based health care, we are witnessing a new enthusiasm for qualitative metasynthesis as an enterprise distinct from conventional literature reviews, secondary analyses, and the many other scholarly endeavors with which it is sometimes confused. This article represents the reflections of five scholars, each ofwhom has authored a distinct qualitative metasynthesis strategy. By providing the reader a glimpse into the tradition of their various qualitative metasynthesis projects, these authors offer a finely nuanced examination of the tensions between comparison and integration, deconstruction and synthesis, and reporting and integration within the metasynthesis endeavor. In so doing, they account for many of the current confusions about representation and generalization within the products of these inquiries. Through understanding the bases of their unique angles of vision, the reader is invited to engage in their commitment to scholarly integrity and intellectual credibility in this emerging methodological challenge.

Meta-Synthesis of Qualitative Findings

A framework for synthesizing qualitative findings is described, and issues surrounding employment of this technique are discussed. Further debate on these issues is encouraged to develop and refine this framework. The practical importance of interpretive meta-synthesis is highlighted in relation to theory development.

Meta-analysis of arterial oxygen saturation monitoring by pulse oximetry in adults

OBJECTIVE The purposes of the study were to: (1) describe the aggregate strength of the relationship of arterial oxygen saturation as measured by pulse oximetry with the standard of arterial blood gas analysis as measured by co-oximetry, (2) examine how various factors affect this relationship, and (3) describe an aggregate estimate of the bias and precision between oxygen saturation as measured by pulse oximetry and the standard in vitro measures. DESIGN A meta-analysis was conducted. SAMPLE Seventy-four studies from 1976 to 1994 met the inclusion criteria of: (1) adult study population, (2) quantitative analysis of empirical data, and (3) bivariate correlations or bias and precision estimates between pulse oximeter and co-oximeter values. RESULTS There were a total of 169 oximeter trials on 41 oximeter models from 25 different manufacturers. Studies were conducted in various settings with a variety of subjects, with most being healthy adult volunteers. The weighted mean r, based on 39 studies (62 oximeter trials) for which the r statistic and number of data points were available, was 0.895 (var [r] = 0.014). Based on 23 studies (82 oximeter trials) for which bias and precision estimates and number of data points were available, the mean absolute bias and precision were 1.999 and 0.233, respectively. Several factors were found to affect the accuracy of pulse oximetry. CONCLUSION Pulse oximeters were found to be accurate within 2% (+/- 1 SD) or 5% (+/- 2 SD) of in vitro oximetry in the range of 70% to 100% Sao2. In comparing ear and finger probes, readings from finger probes were more accurate. Pulse oximeters may fail to record accurately the true Sao2 during severe or rapid desaturation, hypotension, hypothermia, dyshemoglobinemia, and low perfusion states.

Nutrition impact symptoms: Key determinants of reduced dietary intake, weight loss, and reduced functional capacity of patients with head and neck cancer before treatment

Our aim was to evaluate the prevalence and relationship of symptoms with reduced dietary intake, weight, and functional capacity in patients with head and neck cancer.

A review of impedance cardiography

OBJECTIVE To review the reliability and validity estimates of impedance cardiography to assess its empirical precision and clinical usefulness. DATA SOURCE Empirical and theoretical literature mainly within the last 10 years. DATA SYNTHESIS Descriptive statistics used to summarize the accuracy and use of impedance cardiography to estimate stroke volume. CONCLUSIONS Estimation of cardiac output is presently a core component of optimizing cardiac function in many patient populations. Impedance cardiography, which initially used a formula developed by Kubicek et al. and recently a formula developed by Sramek and Bernstein, remains controversial with regard to its accuracy and use in research and clinical practice.

Sex and Gender Discrepancies in Health-Related Quality of Life Outcomes Among Patients With Established Coronary Artery Disease

Background—Although eradicating discrepancies in health is of unquestioned importance, there are few studies examining health-related quality of life (HRQOL) among men and women with coronary artery disease (CAD), a highly prevalent and morbid condition among industrialized nations. This study compares the HRQOL outcomes of men and women in Alberta, Canada, 1 year after the documentation of coronary artery disease by cardiac catheterization. Method and Results—Patients’ disease-specific HRQOL was assessed 1 year after angiography using the Seattle Angina Questionnaire, whereas their generic health status, burden of depressive symptoms, and social support were respectively quantified with the EuroQol EQ-5D, the Center for Epidemiological Studies Depression Scale (short form), and the Medical Outcomes Study social support scale. The latter 2 instruments were used to adjust Seattle Angina Questionnaire outcomes for potential confounding characteristics hypothesized to be associated with sex and gender. General linear modeling and a change in Seattle Angina Questionnaire scores from baseline to 1 year were used to compare the HRQOL outcomes of men and women, after adjusting for demographics, clinical factors, depressive symptoms, and social support differences between groups. A total of 2394 (60% of those eligible) patients responded to the baseline and the 1-year follow-up survey. The adjusted mean 1-year Seattle Angina Questionnaire scores were significantly higher in men when compared with women, even after adjustment for all clinical factors, social support, depressive symptoms, and baseline HRQOL scales. Not only were women noted to have worse health status at the time of angiography, but despite adjusting for these differences, residual discrepancies in 1-year health status persisted. Conclusions—Women with coronary artery disease report worse HRQOL 1 year after coronary angiography when compared with men, and the discrepancies observed are only partially accounted for by sex differences in depression and social support. As a result, the measurement of gender roles and perceptions may be the best place to persist on the quest to identifying and understanding the noted discrepancies in cardiac recovery and HRQOL outcomes.

Living with Change: Elderly Women’s Perceptions of Having a Myocardial Infarction

The purpose of the study described in this article was to explore and describe elderly (70+ years) women’s perceptions of having a myocardial infarction (MI). Structured and unstructured, open-ended, face-to-face interviews with 11 women were used to collect qualitative data. The central theme that emerged was living with change. Five phases were revealed: searching for a diagnosis, being hit with the reality, discovering the nature of the change, adjusting to the change, and moving on with the change. Throughout these phases, the women were faced with the challenges of being in control, managing uncertainty, making sense, being independent, and sheltering others. The continuous process of change in their lives was taken for granted by these women. By having an understanding of the perspective of elderly women who have an MI, nurses will be more effective when caring for these individuals.

Critical evaluation of nutrition screening tools recommended for oncology patients.

Malnutrition ranges from 20% to 80% in oncology patients. Malnutrition has been associated with reduced response to treatment, survival, and quality of life. Therefore, screening for malnutrition in patients with cancer is recommended by clinical practice groups including the Oncology Nursing Society. Nurses are in an ideal position to carry out nutrition screening. Three nutrition screening tools that have been recommended for use with oncology patients by the Oncology Nursing Society are critically evaluated. The Patient Generated-Subjective Global Assessment has demonstrated diagnostic value in oncology patients at risk of malnutrition or who are malnourished.

Alcohol Use While on the Liver Transplant Waiting List: A Single-Center Experience

Alcoholic liver disease (ALD) is a leading indication for liver transplantation. Our center has randomly checked blood alcohol levels (BALs) in ALD patients on the waiting list since 2004. We aimed to identify the incidence and predictors of inactivation on the transplant list due to alcohol use and to determine the utility of BAL‐screening in this process. We conducted a retrospective review of patients with ALD listed for liver transplantation with at least 3 months of postlisting follow‐up. Alcohol use while on the transplant list was defined as a positive BAL, an admission of alcohol use, or refusal to perform screening within 12 hours of request. Cox proportional hazards regression was used to estimate risk ratios (RRs). Of 134 patients meeting eligibility criteria, 78% were male, and mean age was 52 years. Alcohol use was documented in 23 patients (17%). Of these, 12 refused to have a random screen, 8 had detectable serum ethanol levels, and 3 had self‐reported alcohol use. On multivariable analysis, a higher number of random BAL‐checks [RR = 0.63(0.52, 0.76), P = 0.001] and a longer duration of prelisting abstinence [RR = 0.88(0.83, 0.94), P = 0.001] independently reduced the risk of alcohol use by patients while on the waiting list. None of the patients with >24 months of prelisting abstinence had a positive screen. In conclusion, this study supports random BAL‐screening before transplantation and reinforces the importance of abstinence duration as a predictor of relapse. For patients with <24 months of prelisting abstinence, our center will increase the frequency of random BAL screening and increase the rehabilitation requirements to include an intensive 3‐week rehabilitation program. We hope that these measures will reduce the rate of relapse to alcohol use post‐transplantation. Liver Transpl 16:91–97, 2010.

Evaluation of impedance cardiography: Comparison of NCCOM3-R7 with Fick and thermodilution methods

OBJECTIVE To assess the degree of error of the BoMed NCCOM3 model revision seven (R7) impedance cardiograph in determining stroke volume and estimated cardiac output. DESIGN Three-group, within-subject, repeated measures design. SAMPLE Group 1: patients (n = 17) with heart disease undergoing an elective coronary angiogram; group 2: patients (n = 28) after elective heart surgery; and group 3: healthy volunteers (n = 28). MEASUREMENT Cardiac output was determined by the BoMed NCCOM3-R7 impedance cardiograph, Fick principle, and thermodilution method. The NCCOM3-R7 was compared with the direct Fick and thermodilution methods in groups 1 and 2, respectively, to estimate validity coefficients. In group 3, repeated measures were obtained with the NCCOM3-R7 to calculate reliability coefficients. RESULTS The NCCOM3-R7 underestimated Fick measurements by 1.050 +/- 1.529 L/min at rest and 1.505 +/- 2.214 L/min during exercise. Correlation coefficients of 0.684 at rest (p = 0.001) and 0.219 during exercise (p = 0.248) were obtained. The NCCOM3-R7 underestimated thermodilution values by 0.425 +/- 1.325 L/min in subjects initially after heart surgery and 0.358 +/- 1.235 L/min 2 to 4 hours later. Correlation coefficients of 0.547 (p = 0.002) and 0.505 (p = 0.004) were obtained for the two time periods, respectively. A reliability coefficient of 0.837 was calculated with healthy subjects. CONCLUSION The NCCOM3-R7 has a clinically unacceptable level of error for evaluating cardiac performance in patients with heart disease.