Lu-Tai Pan
Guiyang College of Traditional Chinese Medicine
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Organic Letters | 2011
Juan Zou; Lu-Tai Pan; Qi-Ji Li; Junhua Zhao; Jian-Xin Pu; Ping Yao; Ning-Bo Gong; Yang Lu; Tamara P. Kondratyuk; John M. Pezzuto; Harry H. S. Fong; Hong-Jie Zhang; Han-Dong Sun
From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.
Journal of Ethnopharmacology | 2016
Ji-Xin Li; Qi-Ji Li; Yi-Fu Guan; Xun Song; Ya-Hua Liu; Jing-Jie Zhang; Wan-Fei Li; Jiang Du; Min Zhu; Xiao-Nian Li; Lu-Tai Pan; Hong-Jie Zhang
ETHNOPHARMACOLOGICAL RELEVANCE Leigong Mountain is an area in the Southwest of China where there is a high incidence rate of athletes foot, but the Miao people, a Chinese minority who reside in this mountainous area have suffered less from this disease due to their use of the herbal medicine Isodon flavidus (Hand.-Mazz.) H. Hara. AIM OF THE STUDY The present study is to identify the active chemical constituents responsible for antifungal effects of the folk medicine plant. MATERIALS AND METHODS The natural compounds were separated from the methanol extract of the twigs and leaves of I. flavidus by phytochemical study using chromatographic methods, and their chemical structures were determined by analysis of the spectroscopic data including 1D and 2D NMR spectra. The absolute configuration of fladin A (1) was further confirmed by X-ray crystallographic analysis. The compounds were evaluated for their antifungal activity against the athletes foot fungus Trichophyton rubrum. They were further evaluated for their antimicrobial and anti-biofilm activity against the dental pathogens Streptococcus mutans, Porphyromonas gingivalis and Candida albicans. RESULTS Phytochemical and biological studies of I. flavidus led to the discovery of two antifungal compounds, fladin A (1) and lophanic acid (2). Fladin A (1) is a novel diterpene with an unprecedented cyclic ether group formed between C-4 and C-9. Lophanic acid (2) displayed inhibition activity against the athletes foot fungus Trichophyton rubrum with an MIC value of 7.8μg/mL, and fladin A (1) also showed inhibition activity against the fungus with a MIC value of 62.5μg/mL. CONCLUSIONS Our identification of two antifungal compounds provided strong evidence for the Miao people to use I. flavidus as a medicinal plant for treatment of athletes foot disease. The very different chemical structures of the active compounds from those in the market presents them as potential antifungal lead compounds for follow-up study.
Zeitschrift Fur Kristallographie-new Crystal Structures | 2018
Rui Deng; Chen-Liang Zhao; Jiang-Hai Ye; Ya-Hua Liu; Juan Zou; Lu-Tai Pan
Abstract C22H20O8, monoclinic, P21 (no. 4), a = 7.5482(10) Å, b = 7.0055(9) Å, c = 18.245(3) Å, β = 101.709(4)°, V = 944.7(2) Å3, Z = 2, Rgt(F) = 0.0444, wRref(F2) = 0.1199, T = 293(2) K.
Zeitschrift Fur Kristallographie-new Crystal Structures | 2018
Jiang-Hai Ye; Chen-Liang Zhao; Juan Zou; Kang He; Chao-Jie Teng; Lu-Tai Pan
Abstract C20H30O8, monoclinic, C2 (no. 5), a = 21.684(13) Å, b = 7.275(4) Å, c = 14.320(9) Å, β = 118.975(11), V = 1976(2) Å3, Z = 4, Rgt(F) = 0.0362, wRref(F2) = 0.0920, T = 298 K.
Zeitschrift Fur Kristallographie-new Crystal Structures | 2017
Neng-Wu Zhao; Jiang-Hai Ye; Chen-Liang Zhao; Jing-Jie Zhang; Lu-Tai Pan
Abstract C20H24O6, orthorhombic, P212121 (no. 19), a = 7.697(14) Å, b = 13.91(2) Å, c = 16.75(3) Å, V = 1794 Å3, Z = 4, Rgt(F) = 0.0430, wRref(F2) = 0.1087, T = 293 K.
Zeitschrift Fur Kristallographie-new Crystal Structures | 2016
Jiang-Hai Ye; Jing-Jie Zhang; Chen-Liang Zhao; Qi-Long Zhang; Lu-Tai Pan
Abstract C22H30O6, monoclinic, P21/c (no. 14), a = 11.1339(16) Å, b = 6.1262(9) Å, c = 14.771(2) Å, β = 103.567(5)°, V = 1867.9(12) Å3, Z = 2, Rgt(F) = 0.0430, wRref(F2) = 0.1165, T = 293 K.
Zeitschrift Fur Kristallographie-new Crystal Structures | 2016
Jun Lv; Jiang-Hai Ye; Li-Yong Yang; Chen-Liang Zhao; Jing-Jie Zhang; Lu-Tai Pan
Abstract C22H30O6, monoclinic, P21 (no. 14), a = 9.111(3) Å, b = 9.535(3) Å, c = 11.331(4) Å, β = 92.703(4)°, V = 983.3(5) Å3, Z = 2, Rgt(F) = 0.0418, wRref(F2) = 0.1152, T = 293 K.
Zeitschrift Fur Kristallographie-new Crystal Structures | 2012
Lu-Tai Pan; Qi-Ji Li; Jing-Jie Zhang; Ya-Hua Liu; Qi-Long Zhang
C20H28O6, orthorhombic, P212121 (no. 19), a = 7.444(2) Å, b = 14.026(3) Å, c = 17.298(4) Å, V = 1806.0 Å, Z = 4, Rgt(F) = 0.036, wRref(F ) = 0.086, T = 293 K.
Phytochemistry | 1998
Jun Tian; Hong-Jie Zhang; Han-Dong Sun; Lu-Tai Pan; Pin Yao; De-Yuan Chen
中国化学快报:英文版 | 1996
Jun Tian; Hong-Jie Zhang; Han-Dong Sun; Lu-Tai Pan; Ping Yao; Dy Chen