Lubica Raptova
Hoffmann-La Roche
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Publication
Featured researches published by Lubica Raptova.
Bioorganic & Medicinal Chemistry Letters | 2008
Linda M. Bannwart; David S. Carter; Hai-Ying Cai; Jason Chi-Chung Choy; Robert Greenhouse; Saul Jaime-Figueroa; Pravin Iyer; Clara Jeou Jen Lin; Eun Kyung Lee; Matthew C. Lucas; Stephen M. Lynch; Ann Marie Madera; Amy Geraldine Moore; Kerem Erol Ozboya; Lubica Raptova; Ralf Roetz; Ryan Craig Schoenfeld; Karin Ann Stein; Sandra Steiner; Marzia Villa; Robert James Weikert; Yansheng Zhai
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro permeability, and low drug-drug interaction potential are described. One example showed in vivo anti-depressant-like effects in the mouse tail suspension assay with a minimum effective dose of 30 mg/kg i.p.
Archive | 2003
Robert Greenhouse; Saul Jaime-Figueroa; Lubica Raptova
Archive | 2005
Robert Greenhouse; Saul Jaime-Figueroa; Lubica Raptova; Deborah Carol Reuter; Karin Ann Stein; Robert James Weikert
Archive | 2006
Robert Greenhouse; Saul Jaime-Figueroa; Stephen M. Lynch; Lubica Raptova; Karin Ann Stein; Robert James Weikert
Archive | 2009
Leyi Gong; Xiaochun Han; Ferenc Makra; Wylie Solang Palmer; Lubica Raptova
Archive | 2006
Robert Greenhouse; Saul Jaime-Figueroa; Stephen M. Lynch; Lubica Raptova; Karin Ann Stein; Robert James Weikert
Archive | 2005
Robert Greenhouse; Saul Jaime-Figueroa; Lubica Raptova; Deborah Carol Reuter; Karin Ann Stein; Robert James Weikert
Archive | 2005
Robert Greenhouse; Saul Jaime-Figueroa; Lubica Raptova; Deborah Carol Reuter; Karin Ann Stein; Robert James Weikert
Archive | 2005
Robert Greenhouse; Saul Jaime-Figueroa; Lubica Raptova; Deborah Carol Reuter; Karin Ann Stein; Robert James Weikert
Archive | 2003
Robert Newark Greenhouse; Saul Jaime-Figueroa; Lubica Raptova
