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Dive into the research topics where Luciano Lobato Gregorio is active.

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Featured researches published by Luciano Lobato Gregorio.


International Forum of Allergy & Rhinology | 2017

A validated model for the 22-item Sino-Nasal Outcome Test subdomain structure in chronic rhinosinusitis

Allen L. Feng; Nicholas C. Wesely; Lloyd P. Hoehle; Katie M. Phillips; Alisa Yamasaki; Adam P. Campbell; Luciano Lobato Gregorio; Thomas E. Killeen; David S. Caradonna; Josh Meier; Stacey T. Gray; Ahmad R. Sedaghat

Previous studies have identified subdomains of the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), reflecting distinct and largely independent categories of chronic rhinosinusitis (CRS) symptoms. However, no study has validated the subdomain structure of the SNOT‐22. This study aims to validate the existence of underlying symptom subdomains of the SNOT‐22 using confirmatory factor analysis (CFA) and to develop a subdomain model that practitioners and researchers can use to describe CRS symptomatology.


American Journal of Rhinology & Allergy | 2016

Impact of endoscopic dacryocystorhinostomy on sinonasal quality of life.

Marcel M. Miyake; Luciano Lobato Gregorio; Suzanne K. Freitag; Daniel R. Lefebvre; Stacey T. Gray; Eric H. Holbrook; Benjamin S. Bleier

Background Dacryocystorhinostomy (DCR) is the criterion standard of surgical treatment for complete nasolacrimal obstruction and dacryocystitis. There has been an expansion in the indication of the endonasal DCR (eDCR), but the impact of surgical manipulating an otherwise healthy nasal mucosa on postoperative sinonasal quality of life remains unknown. The purpose of this study was to determine whether patients who underwent eDCR experienced any decrement in sinonasal quality of life. Methods A retrospective chart review of 44 patients who underwent eDCR between June 2012 and May 2015. The primary outcome was the total and nasal-specific domain 1 scores of the disease specific validated Sino-Nasal Outcomes Test 22. Preoperative scores were compared with the postoperative scores on days 0-30, 30-90, and 90-180 visits. A subgroup analysis of patients without nasal symptoms who underwent concomitant nasal surgical procedures was also performed. Results A statistically significant increase was observed between the preoperative score and the first postoperative score (days 0-30) in both total (7.5 [0-44] to 24 [0-51], median [interquartile range]) and domain 1 (2.5 [0-11] to 9 [0-18]) scores (p = 0.0066 and p = 0.0001, respectively). In contrast, there was no statistically significant difference between the pre- and postoperative scores on days 30-90 or 90-180. Similar results were observed in the subgroup analysis. Conclusion Analysis of our findings indicated that, in general, eDCR was well tolerated by patients and nasal symptom scores returned to baseline values within 30-90 days of surgery. The concomitant performance of septoplasty in the setting of asymptomatic septal deviation did not confer any long-term improvement in symptoms of nasal obstruction.


Clinical Otolaryngology | 2015

Influence of age and gender in the normal values of Sino Nasal Outcome Test–22

Luciano Lobato Gregorio; J.S.C. Andrade; Fábio Caparroz; P. Saraceni Neto; Eduardo Macoto Kosugi

Sino Nasal Outcome Test (SNOT)‐22 is a disease‐specific outcomes measure questionnaire that combines rhinologic issues with general health issues. These issues may have variable weight on quality of life perception, and the influence of several factors such as gender, ethnicity, age, socio‐cultural status and co‐morbidities is unknown. The aim of this study was to evaluate the influence of gender and age on normal values of SNOT‐22.


Laryngoscope | 2017

General antibiotic exposure is associated with increased risk of developing chronic rhinosinusitis.

Alice Z. Maxfield; Hakan Korkmaz; Luciano Lobato Gregorio; Nicolas Y. Busaba; Stacey T. Gray; Eric H. Holbrook; Rong Guo; Benjamin S. Bleier

Antibiotic use and chronic rhinosinusitis (CRS) have been independently associated with microbiome diversity depletion and opportunistic infections. This study was undertaken to investigate whether antibiotic use may be an unrecognized risk factor for developing CRS.


Revista Brasileira De Otorrinolaringologia | 2013

Evolution of endoscopic surgery in the treatment of inverted papilloma

Fábio Caparroz; Luciano Lobato Gregorio; Eduardo Macoto Kosugi

UNLABELLED Inverted papilloma (IP) has several treatment avenues. The endoscopic approach in the last decade has proven to be a good option over the traditional approach. OBJECTIVE Describe the epidemiological profile of patients with inverted Papilloma, describe our experience on managing this tumor and compare our data with the literature. STUDY DESIGN Cross-sectional, historical cohort. METHOD Retrospective study of medical records of 17 patients treated for histopathologicallyconfirmed inverted papilloma between 2005 and 2011. We assessed patients age, gender, tumor side, symptoms, diagnosis, comorbidities and habits, Krouse staging, surgical approach, intraoperative and postoperative, and malignant postoperative recurrence and also the correlation between recurrence with preoperative staging, the surgical approach used, and the presence of malignancy. RESULTS Five (29.41%) patients were classified as Krouse stage T2, 9 (52.94%) as T3 and 3 (17.65%) as T4. Three (17.65%) patients had malignancy and the recurrence rate was 23.5% (4 pacients). Eleven patients (64.70%) underwent endoscopic approach, 3 (17.6%) the combined aprroach (endoscopic assisted) and 3 (17.6%) external approach. CONCLUSION The endoscopic approach is currently becoming a method not only effective but also safe for the treatment of more advanced stages of IP.


International Forum of Allergy & Rhinology | 2017

Resection of the ethmoidal crest in sphenopalatine artery surgery

Paulo Saraceni Neto; Leonardo Mendes Acatauassú Nunes; Fábio Caparroz; Luciano Lobato Gregorio; Rafael de Paula e Silva Felice de Souza; Juliana Caminha Simões; Eduardo Macoto Kosugi

In severe cases of epistaxis, in spite of several procedures described in the literature for its management, surgical treatment has been recognized by most authors as 1 of the most effective, especially when it includes ligation and/or electrocoagulation of the nasal branches of the sphenopalatine artery. The objective of this study is to determine the importance of ethmoid crest resection during sphenopalatine artery surgery, in the management of severe epistaxis.


Revista Brasileira De Otorrinolaringologia | 2016

Orofacial-cervical alterations in individuals with upper airway resistance syndrome

Pedro Wey Barbosa de Oliveira; Luciano Lobato Gregorio; Rogério Santos Silva; L.R.A. Bittencourt; Sergio Tufik; Luis Carlos Gregório

INTRODUCTION Studies that assess the upper airways in sleep-related breathing disorders have been performed only in patients with obstructive sleep apnea syndrome who seek medical attention. Therefore, in addition to the need for population studies, there are no data on the orofacial-cervical physical examination in subjects with upper airway resistance syndrome. OBJECTIVES To compare the orofacial-cervical examination between volunteers with upper airway resistance syndrome and without sleep-related breathing disorders. METHODS Through questionnaires, physical measurements, polysomnography, and otorhinolaryngological evaluation, this study compared the orofacial-cervical physical examination, through a systematic analysis of the facial skeleton, mouth, throat, and nose, between volunteers with upper airway resistance syndrome and volunteers without sleep-related breathing disorders in a representative sample of the adult population of the city of São Paulo. RESULTS There were 1042 volunteers evaluated; 49 subjects (5%) were excluded as they did not undergo otorhinolaryngological evaluation, 381 (36%) had apnea-hypopnea index>5 events/hour, and 131 (13%) had oxyhemoglobin saturation<90%. Among the remaining 481 subjects (46%), 30 (3%) met the criteria for the upper airway resistance syndrome definition and 53 (5%) met the control group criteria. At the clinical evaluation of nasal symptoms, the upper airway resistance syndrome group had more oropharyngeal dryness (17% vs. 29.6%; p=0.025) and septal deviation grades 1-3 (49.1% vs. 57.7%; p=0.025) when compared to controls. In the logistic regression model, it was found that individuals from the upper airway resistance syndrome group had 15.6-fold higher chance of having nose alterations, 11.2-fold higher chance of being hypertensive, and 7.6-fold higher chance of complaining of oropharyngeal dryness when compared to the control group. CONCLUSION Systematic evaluation of the facial skeleton, mouth, throat, and nose, between volunteers with upper airway resistance syndrome and volunteers without sleep-related breathing disorders, showed that the presence of upper airway resistance syndrome is mainly associated with nasal alterations and oropharyngeal dryness, in addition to the risk of hypertension, regardless of gender and obesity.


Laryngoscope | 2015

Lobular capillary hemangioma formation: An unusual complication of submucous resection with power instrumentation of the inferior turbinate.

Luciano Lobato Gregorio; Chin-Lee Wu; Nicolas Y. Busaba

Submucous resection with powered instrumentation (SRPI) is an effective surgical method to achieve inferior turbinate (IT) reduction with minimal morbidity. We describe a series of two cases of capillary hemangioma (pyogenic granuloma) that developed in the posterior third of the IT as a late complication after SRPI. Laryngoscope, 125:2653–2655, 2015


Revista Brasileira De Otorrinolaringologia | 2014

Olfaction disorders: retrospective study

Luciano Lobato Gregorio; Fábio Caparroz; Leonardo Mendes Acatauassú Nunes; Luciano Rodrigues Neves; Eduardo Kosugi Macoto

Introduction: The smell, subjective phenomenon of great importance, is poorly understood and studied in humans. Physicians with more knowledge about smell disorders tend to consider the phenomenon important and to better manage the diagnosis and its treatment. Aims: First to describe a sample of patients presenting with main complaint of disturbances of smell. And second, to show our experience on management and treatment of this disease. Design: Retrospective cross-sectional cohort study. Materials and methods: Sample description and assessment of treatment response in patients with main complaint of hyposmia or anosmia from January 2005 to October 2011. Results: From 38 patients presented with main complaint of an olfactory disorder, 68.4% of the patients were presented with hyposmia and 31,5% with anosmia, with a mean duration of 30.8 months. The main etiologic diagnoses were idiopathic (31.5%), rhinitis (28.9%) and CRS with polyps (10.5%). Responses to treatment with topical steroids and alpha-lipoic acid were variable, as well as in the literature. Conclusion: Greater importance should be given to disorders of smell in practice of otolaryngologists, since its large differential diagnosis and the fact that could increase morbidity to patients, impacting on their quality of life.INTRODUCTION The smell, subjective phenomenon of great importance, is poorly understood and studied in humans. Physicians with more knowledge about smell disorders tend to consider the phenomenon important and to better manage the diagnosis and its treatment. AIMS First to describe a sample of patients presenting with main complaint of disturbances of smell. And second, to show our experience on management and treatment of this disease. DESIGN Retrospective cross-sectional cohort study. MATERIALS AND METHODS Sample description and assessment of treatment response in patients with main complaint of hyposmia or anosmia from January 2005 to October 2011. RESULTS From 38 patients presented with main complaint of an olfactory disorder, 68.4% of the patients were presented with hyposmia and 31,5% with anosmia, with a mean duration of 30.8 months. The main etiologic diagnoses were idiopathic (31.5%), rhinitis (28.9%) and CRS with polyps (10.5%). Responses to treatment with topical steroids and alpha-lipoic acid were variable, as well as in the literature. CONCLUSION Greater importance should be given to disorders of smell in practice of otolaryngologists, since its large differential diagnosis and the fact that could increase morbidity to patients, impacting on their quality of life.


Revista Brasileira De Otorrinolaringologia | 2014

Distúrbios da olfação: estudo retrospectivo

Luciano Lobato Gregorio; Fábio Caparroz; Leonardo Mendes Acatauassú Nunes; Luciano Rodrigues Neves; Eduardo Kosugi Macoto

Introduction: The smell, subjective phenomenon of great importance, is poorly understood and studied in humans. Physicians with more knowledge about smell disorders tend to consider the phenomenon important and to better manage the diagnosis and its treatment. Aims: First to describe a sample of patients presenting with main complaint of disturbances of smell. And second, to show our experience on management and treatment of this disease. Design: Retrospective cross-sectional cohort study. Materials and methods: Sample description and assessment of treatment response in patients with main complaint of hyposmia or anosmia from January 2005 to October 2011. Results: From 38 patients presented with main complaint of an olfactory disorder, 68.4% of the patients were presented with hyposmia and 31,5% with anosmia, with a mean duration of 30.8 months. The main etiologic diagnoses were idiopathic (31.5%), rhinitis (28.9%) and CRS with polyps (10.5%). Responses to treatment with topical steroids and alpha-lipoic acid were variable, as well as in the literature. Conclusion: Greater importance should be given to disorders of smell in practice of otolaryngologists, since its large differential diagnosis and the fact that could increase morbidity to patients, impacting on their quality of life.INTRODUCTION The smell, subjective phenomenon of great importance, is poorly understood and studied in humans. Physicians with more knowledge about smell disorders tend to consider the phenomenon important and to better manage the diagnosis and its treatment. AIMS First to describe a sample of patients presenting with main complaint of disturbances of smell. And second, to show our experience on management and treatment of this disease. DESIGN Retrospective cross-sectional cohort study. MATERIALS AND METHODS Sample description and assessment of treatment response in patients with main complaint of hyposmia or anosmia from January 2005 to October 2011. RESULTS From 38 patients presented with main complaint of an olfactory disorder, 68.4% of the patients were presented with hyposmia and 31,5% with anosmia, with a mean duration of 30.8 months. The main etiologic diagnoses were idiopathic (31.5%), rhinitis (28.9%) and CRS with polyps (10.5%). Responses to treatment with topical steroids and alpha-lipoic acid were variable, as well as in the literature. CONCLUSION Greater importance should be given to disorders of smell in practice of otolaryngologists, since its large differential diagnosis and the fact that could increase morbidity to patients, impacting on their quality of life.

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Fábio Caparroz

Federal University of São Paulo

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Eduardo Macoto Kosugi

Federal University of São Paulo

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Eduardo Kosugi Macoto

Federal University of São Paulo

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Luciano Rodrigues Neves

Federal University of São Paulo

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Benjamin S. Bleier

Massachusetts Eye and Ear Infirmary

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Nicolas Y. Busaba

Massachusetts Eye and Ear Infirmary

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Stacey T. Gray

Massachusetts Eye and Ear Infirmary

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Juliana Caminha Simões

Federal University of São Paulo

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Eric H. Holbrook

Massachusetts Eye and Ear Infirmary

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