Luigi Annacontini

Surgical Approach to Head and Neck Cancer and Postoperative Complications : Are All Patients Eligible?

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LOP28: Hyaluronic acid nerve guide for peripheral nerve injury repair up to 2cm

Results: Using HPLC measurement we were able to detect different amounts of doxorubicin, vincristine, and vinblastine in exosomes and cell culture, patients supernatants. We confirmed significant inhibitions of exosome release occurring at nontoxic concentrations of the drugs. Diminished exosome release was associated with increased efficacy of immunochemotherapy. Also, silencing of ABCA3 by lentiviral shRNA constructs reduced exosome release from the cell line models Balm-3, Su-DHL-4, and OCI-Ly1. Concordantly, silencing ABCA3 also increased the susceptibility of the lymphoma cells to immunochemotherapy. Conclusion: We here found that exosomes participates in resistance to chemotherapy. Both pharmacological blockade and silencing of ABCA3 enhanced the susceptibility of target cells to cytotoxic agents.