Luis Carlos Cucé

The influence of the amount of sunscreen applied and its sun protection factor (SPF): evaluation of two sunscreens including the same ingredients at different concentrations

Background: To estimate labeled sun protection factor (SPF) for sunscreen, the amount of product applied on volunteers, according to food and drug administration (FDA) and International protocols, is 2 mg/cm2. However, different studies have shown that consumers actually apply much less product when exposed to the sun. Previous studies have reported contradictory findings in an attempt to correlate the amount applied in relation to SPF. The objective of the present study was to estimate the influence of the quantity of sunscreen applied in the determination of SPF, according to the FDA methodology.

Rhinofacial zygomycosis caused by Conidiobolum coronatus

A case of rhinofacial zygomycosis with of years duration, caused by Conidiobolus coronatus is described. The patient, a 72-years-old woman, presented with a bilateral distortion of the subcutaneous tissue and disfigurement of the face. Treatment with ketoconazole and potasium iodide did not prevent several relapses. At present she is still under treatment with fluconazole with clinical healing. Histopathological and mycological examination confirmed the dermatological diagnosis. An increasing number of cases of zygomycosis caused by fungi of the order Entomophthorales have also been reported in the Northern and Northeastern States of Brazil.

Eumicetoma de grãos pretos por Madurella grisea: registro de dois casos

Two cases of black grains eumycotic mycetoma, occurring on a foot, are reported. Both proceeded from the State of Bahia (Brazil), and in both the etiologic agent was Madurella grisea Mackinnon et al., 1949. The grains structure as well as the micromorphologic characteristics of the fungus in saprophytic life were studied. It is the Authors belief that these observations correspond to the 7th and 8th cases reported in the Brazilian medical literature. The Authors do consider the following Madurella species as nomen dubium or nomina confusa: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae and the same for Rubromadurella mycetomi. The only valid species must be Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) and Madurella grisea Mackinnon et al., 1949. Treatment with itraconazole in both reported cases, for a 3 month duration, did not produce any regression of the lesions, the clinical improvement being meager.Os Autores registram dois casos de eumicetoma de graos pretos, com localizacao podal, procedentes da Bahia, provocados por Madurella grisea Mackinnon et al., 1949. Sao estudadas a estrutura dos graos, bem como as caracteristicas micromorfologicas do fungo em vida saprofitica. Acreditam os Autores que estas observacoes correspondem ao setimo e oitavo casos registrados na literatura do pais, provocadas por este fungo. Os Autores consideram nomen dubium ou nomina confusa as seguintes especies de Madurella: M. ramiroi, M. oswaldoi, M. bovoi, M. tozeuri, M. mansonii, M. brumpti, M. reynieri, M. americana, M. lackawanna e M. ikedae, o mesmo ocorrendo com a chamada Rubromadurella mycetomi. As unicas especies validas sao Madurella mycetomatis McGinnis, 1980 (=Madurella mycetomi Brumpt, 1905) e Madurella grisea Mackinnon et al., 1949. Nos dois casos registrados o tratamento com itraconazol, por um periodo de 3 meses nao fez regredir as lesoes, havendo ligeira melhora clinica.

Alterações renais por hipersensibilidade ao uso de antimonial pentavalente (Glucantime®) na leishmaniose tegumentar americana: relato de um caso

The authors report one case of leishmaniasis in a 60 year old patient who developed renal failure after treatment with Glucantime. With the interruption of these drug the patient recovered her normal renal function, and a new treatment with Amphotericin B was tried with complete cicatrization of the lesions.Os autores apresentam caso de Leishmaniose Tegumentar Americana em paciente de 60 anos, que desenvolveu quadro de insuficiencia renal aguda nao oligurica e reversivel associada a erupcao urticariforme na pele apos inicio de tratamento com Glucantime®. A diagnose do quadro renal foi estabelecida por biopsia renal que revelou nefrite intersticial aguda e necrose tubular aguda. Apos a suspensao da droga houve restabelecimento da funcao renal, sendo a mesma tratada com Anfotericina B, evoluindo com cicatrizacao completa das lesoes, nao tendo apresentado alteracoes significantes da funcao renal, controlada semanalmente pela dosagem serica de ureia, creatinina, sodio e potassio.

Eumicetoma de gräos pretos por Madurella grisea

The authors reported one case of eumycotic mycetoma due to Madurella grisea (black grains) occurred on the right foot of the patient studied. The structure, microscopic morphology and therapeutic evolution are also studied and reported.

Tinha favosa: relato de ocorrência familiar em Itapecerica da Serra (município da Grande São Paulo)

Four cases of Tinea favosa occurred in the same family are reported in a small city of Brazil (Itapecerica da Serra--State of São Paulo). Trichophyton schoenleinii was isolated from all four cases. Treatment consisted of oral griseofulvin (10 mg/kg/day) for at least three months.Four cases of Tinea favosa occurred in the same family are reported in a small city of Brazil (Itapecerica da Serra - State of Sao Paulo). Trichophyton schoenleinii was isolated from all four cases. Treatment consisted of oral griseofulvin (10 mg/kg/day) for at least three months.Os autores relatam 4 casos de tinha favosa por Trichophyton schoenleinii de ocorrencia familiar, identificados na cidade de Itapecerica da Serra, municipio da Grande Sao Paulo. Todos os casos foram tratados com griseofulvina por via oral na dose de 1.0 mg/kg/dia por no minimo 3 meses, tendo ocorrido cura clinica e laboratorial em 2 pacientes, e os dois restantes necessitaram de terapeutica mais prolongada.

Tinea favosa: familiar occurence in Itapecerica da Serra (São Paulo State - Brazil)

Four cases of Tinea favosa occurred in the same family are reported in a small city of Brazil (Itapecerica da Serra--State of São Paulo). Trichophyton schoenleinii was isolated from all four cases. Treatment consisted of oral griseofulvin (10 mg/kg/day) for at least three months.Four cases of Tinea favosa occurred in the same family are reported in a small city of Brazil (Itapecerica da Serra - State of Sao Paulo). Trichophyton schoenleinii was isolated from all four cases. Treatment consisted of oral griseofulvin (10 mg/kg/day) for at least three months.Os autores relatam 4 casos de tinha favosa por Trichophyton schoenleinii de ocorrencia familiar, identificados na cidade de Itapecerica da Serra, municipio da Grande Sao Paulo. Todos os casos foram tratados com griseofulvina por via oral na dose de 1.0 mg/kg/dia por no minimo 3 meses, tendo ocorrido cura clinica e laboratorial em 2 pacientes, e os dois restantes necessitaram de terapeutica mais prolongada.